Publications

2016

Students

  • S Moriya, D Chourasia, KW Ng, NB Khel, IS Parhar (2016) Cloning and localization of immediate early response 2 (ier2) gene in the brain of medaka. Journal of chemical neuroanatomy 77, 24-29
  • S Moriya, T Soga, DW Wong, IS Parhar (2016) Transcriptome composition of the preoptic area in mid-age and escitalopram treatment in male mice. Neuroscience letters 622, 67-71
  • YM Khor, T Soga, IS Parhar (2016) Early-life stress changes expression of GnRH and kisspeptin genes and DNA methylation of GnRH3 promoter in the adult zebrafish brain. General and comparative endocrinology 227, 84-93
  • CY Hang, T Kitahashi, IS Parhar (2016) Neuronal Organization of Deep Brain Opsin Photoreceptors in Adult Teleosts. Front Neuroanat. 2016; 10: 48. doi:  10.3389/fnana.2016.00048
  • T Soga, WL Lim, ASB Khoo, IS Parhar (2016) Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons. Front Endocrinol (Lausanne). 2016; 7: 15. doi:  10.3389/fendo.2016.00015
  • FT Lim, S Ogawa, IS Parhar (2016) Spred-2 expression is associated with neural repair of injured adult zebrafish brain. Journal of Chemical Neuroanatomy 77, 176-186
  • FT Lim, S Ogawa, IS Parhar (2016) Association between apoptotic neural tissue and cell proliferation in the adult teleost brain. Brain Research 1650, 60-72
  • FT Lim, S Ogawa, AI Smith, IS Parhar (2016) Proteomics Identification of Potential Candidates Involved in Cell Proliferation for Early Stage of Brain Regeneration in the Adult Zebrafish. Zebrafish 14(1):10-22. doi: 10.1089/zeb.2016.1319.
  • CY Hang, S Moriya, S Ogawa, IS Parhar (2016) Deep Brain Photoreceptor (val-opsin) Gene Knockout Using CRISPR/Cas Affects Chorion Formation and Embryonic Hatching in the Zebrafish. PloS one 11 (10), e0165535
  • M Putteeraj, T Soga, T Ubuka, IS Parhar (2016) A “Timed” Kiss Is Essential for Reproduction: Lessons from Mammalian Studies.  Frontiers in Endocrinology 7, 121

Staff

  • Satoshi Ogawa, Mageswary Sivalingam, Jakob Biran, Matan Golan, Rachel Shalini Anthonysamy, Berta Levavi‐Sivan, Ishwar S Parhar (2016) Distribution of LPXRFa, a gonadotropin‐inhibitory hormone ortholog peptide, and LPXRFa receptor in the brain and pituitary of the tilapia. J Comp Neurol. 2016 Feb 24. doi: 10.1002/cne.23990
  • IS Parhar, S Ogawa, T Ubuka (2016) Reproductive neuroendocrine pathways of social behavior. Front Endocrinol (Lausanne). 2016; 7: 28. doi:  10.3389/fendo.2016.00028
  • IS Parhar, T Soga, S Ogawa (2016) Editorial: Reproductive Neuroendocrinology and Social Behavior. Front Neurosci. 2016; 10: 124. doi:  10.3389/fnins.2016.00124
  • Ubuka T (2016) RFamide peptides in agnathans and basal chordates. General and comparative endocrinology227, 94-100
  • Ubuka T (2016) Putting the brakes on reproduction: Implications for conservation, global climate change and biomedicine. General and comparative endocrinologyGCE 227, 16-26
  • Ubuka T (2016) Contribution of GnIH Research to the Progress of Reproductive Neuroendocrinology. Frontiers in Endocrinology, 6, 179
  • Ubuka T (2016) Avian Test Battery for the Evaluation of Developmental Abnormalities of Neuro- and Reproductive Systems. Front Neurosci. 2016 Jun 30;10:296. doi: 10.3389/fnins.2016.00296

Collaborator

  • MA Camerino, M Liu, S Moriya, T Kitahashi, A Mahgoub, SJ Mountford, DK Chalmers, T Soga, IS Parhar, PE Thompson (2016) Beta amino acid‐modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity. Journal of Peptide Science 22 (6), 406-414
  • Anukulthanakorn K, Parhar IS, Jaroenporn S, Kitahashi T, Watanbe G, Malaivijitnond S (2016) Phytother Res. 30(6):929-39
  • Son Y.L., Ubuka T., Soga T., Yamamoto K., Bentley G.E., Tsutsui K. (2016) Inhibitory action of gonadotropin-inhibitory hormone on the signaling pathways induced by kisspeptin and vasoactive intestinal polypeptide in GnRH neuronal cell line, GT1-7. FASEB Journal 30(6) 2198-210
  • Tipsuda Thongbuakaew, Jirawat Saetan, Saowaros Suwansa-ard, Wilairat Kankoun, Chanudporn Sumpownon, Ishwar Parhar, Prasert Meeratana, Prasert Sobhon, Prapee Sretarugsa (2016) The existence of kisspeptin-like peptides and effects on ovarian development and maturation in the giant freshwater prawn Macrobrachium rosenbergii. Aquaculture 455, 50-62

2015

Students

  • SL Teoh, S Ogawa, IS Parhar (2015) Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Journal of Chemical Neuroanatomy 70, 20-32
  • Tomoko Soga, Chuin Hau Teo, kai Lin Cham, Marshita Idris, Ishwar S Parhar (2015) Early-life Social Isolation Impairs the Gonadotropin-Inhibitory Hormone Neuronal Activity and Serotonergic System in Male Rats. Frontiers in Endocrinology, section Experimental Endocrinology. doi: 10.3389/fendo.2015.00172
  • Dutt Way Wong, Tomoko Soga, Ishwar S Parhar (2015) Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice. Frontiers in Genetics  6:281. doi: 10.3389/fgene.2015.00281
  • Fatima M Nathan, Satoshi Ogawa, Ishwar S Parhar (2015)   Neuronal Connectivity between Habenular Glutamate-Kisspeptin1 Co-expressing Neurons and the Raphe 5-HT System. Journal of Neurochemistry (Impact Factor: 4.28). doi: 10.1111/jnc.13273
  • Parvathy Prasad, Satoshi Ogawa,  Ishwar S Parhar (2015) Serotonin Reuptake Inhibitor Citalopram Inhibits GnRH synthesis and Spermatogenesis in the Male Zebrafish.  Biology of Reproduction (Impact Factor: 3.32) 93(4):102. doi: 10.1095/biolreprod.115.129965
  • Parvathy Prasad, Satoshi Ogawa, Ishwar S. Parhar (2015) Role of serotonin in fish reproduction. Frontiers in Neuroscience (Impact Factor :3.66) 9:195. doi: 10.3389/fnins.2015.00195
  • Chong Yee Hang, Takashi Kitahashi, Ishwar S Parhar (2015) Brain area-specific diurnal and photic regulation of val-opsinA and val-opsinB genes in the zebrafish. Journal of Neurochemistry (Impact Factor: 4.28)  133(4): pp 501-510. DOI:10.1111/jnc.13084
  • Shogo Moriya, Nazmina Bahadur Khel, Ishwar S. Parhar (2015) Cloning and Serotonergic Regulation of RING Finger Protein38 (rnf38) in the Brain of Medaka (Oryzias latipes) Neuroscience (Impact Factor: 3.36) ; 294 pp 109-15. doi: 10.1016/j.neuroscience.2015.03.012
  • Fatima M. Nathan, Satoshi Ogawa, Ishwar S. Parhar (2015) Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT1A and 5-HT2) in zebrafish. Journal of Neurochemistry (Impact Factor: 4.28) 133(6):pp 870-8. doi: 10.1111/jnc.13105

Collaborator

  • Tang H, Liu Y, Luo D, Ogawa S, Yin Y, Li S, Zhang Y, Hu W, Parhar IS, Lin H, Liu X, Cheng CH. (2015) The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology 156(2):589-99.
  • Sumit Sethi, Dipti Chourasia, Ishwar S Parhar (2015) Approaches for targeted proteomics and its potential applications in neuroscience. Journal of Biosciences (Impact Factor:2.06) 40(3). pp 607-627
  • Loong Hung Teng * Munirah Ahmad * Wayne Tiong Weng Ng * Subathra Sabaratnam * Maria Ithaya Rasan * Ishwar Parhar * Alan Soo Beng Khoo (2015) Gonadotropin releasing hormone inhibits the proliferation and motility of nasopharyngeal carcinoma cells. Molecular Medicine Reports (Impact Factor: 1.55)  12(4):4909-16. doi: 10.3892/mmr.2015.4043
  • Nilesh Kumar Mitra, C. Y. Tan , Umesh Bindal, Chua Lin Lin, Wong Eng Hwa, Ishwar Parhar, Tomoko Soga (2015) Investigating Cell Surface Markers and Differentiation Potential of Compact Bone-Derived Mesenchymal Stem Cells. International Journal of Stem Cell Research and Transplantation (IJST) 03(1), pp 91-95.

2014

Students

  • S Ogawa, FM Nathan, Parhar IS (2014) Habenular Kisspeptin Modulates Fear in the Zebrafish. Proceedings of the National Academy of Sciences 11;111(10):3841-6
  • Lim WL., Soga T, Parhar IS Maternal Dexamethasone Exposure during Pregnancy in Rats Disrupts Gonadotropin-Releasing Hormone Neuronal Development in the Offspring. Cell and Tissue Research 355(2):409-23
  • Lim, WL., Soga, T., Parhar IS (2014) Maternal dexamethasone exposure inhibits the gonadotropin-releasing hormone neuronal movement in thepreoptic area of rat offspring.Dev Neurosci. 2014;36(2):95-107. doi: 10.1159/000360416. Epub 2014 Apr 3
  • T Soga, CH Teo, KL Cham, MM Idris, IS Parhar (2014) Early-Life Social Isolation Impairs the Gonadotropin-Inhibitory Hormone Neuronal Activity and Serotonergic System in Male Rats. Frontiers in endocrinology 6, 172-172
  • P Prasad, S Ogawa, IS Parhar (2014) Role of serotonin in fish reproduction. Frontiers in neuroscience 9, 195-195
  • CY Hang, T Kitahashi, IS Parhar (2014) Localization and characterization of val‐opsin isoform‐expressing cells in the brain of adult zebrafish. Journal of Comparative Neurology 522 (17), 3847-3860

Staff

  • Ogawa S and Parhar I (2014). Structural and Functional Divergence of Gonadotropin-Inhibitory Hormone (GnIH) from Jawless Fish to Mammals. Front. Endocrinol. 5:177. doi: 10.3389/fendo.2014.00177
  • Soga,T., Kitahashi T., Iain J Clarke, Parhar IS
    Gonadotropin-Inhibitory Hormone Promoter-Driven Enhanced Green Fluorescent Protein Expression Decreases During Aging in Female Rats  
    (Endocrinology) 155(5):1944-55
  • Md Shahjahan, Takashi Kitahashi, Ishwar S Parhar
    Central Pathways Integrating Metabolism and Reproduction in Teleosts
    (Frontiers in Endocrinology, section Experimental)

Collaborator

  • J Biran, M Golan, N Mizrahi, S Ogawa, IS Parhar, B Levavi Sivan (2014) LPXRFa, the Piscine Ortholog of GnIH, and LPXRF Receptor Positively Regulate Gonadotropin Secretion in Tilapia (Oreochromis niloticus). Endocrinology 155 (11), 4391-4401
  • J Biran, M Golan, N Mizrahi, S Ogawa, IS Parhar, B Levavi Sivan (2014) Direct Regulation of Gonadotropin Release by Neurokinin B in Tilapia (Oreochromis niloticus). Endocrinology 155 (12), 4831-4842
  • Ando H, Ogawa S, Shahjahan M, Ikegami T, Doi H, Hattori A, Parhar I
    Diurnal and circadian oscillations in expression of kisspeptin, kisspeptin receptor and gonadotrophin-releasing hormone 2 genes in the grass puffer, a semilunar-synchronised spawner (Journal of Neuroendocrinol) 2014 May 13. doi: 10.1111/jne.1216
  • Ramyani Taran, Murali Krishna Mamidi, Gurbind Singh, Susmita Dutta, Ishwar S Parhar, John P. John, Ramesh Bhonde, Rajasrshi Pal, Anjan Das
    In-vitro and in-vivo neurogenic potential of mesenchymal stem cells isolated from different sources (Journal of Biosciences)  39(1):157-69

2013

Students

  • Khor YM, Soga T, Parhar IS
    Caffeine neuroprotects against dexamethasone-induced anxiety-like behaviour in the Zebrafish (Danio rerio)
    (General and Comparative Endocrinology)  181:310-315   doi: 10.1016/j.ygcen.2012.09.021
  • Horii Y, Dalpatadu SL, Soga T, Ohta R, Watanabe G, Taya K, Parhar IS.
    Estrogenic regulation of Kiss1 mRNA variants in Hatano rats
    (General and Comparative Endocrinology) 181:246-253  doi: 10.1016/j.ygcen.2012.10.004
  • R Gopurappilly, S Ogawa, Parhar IS
    Functional significance of GnRH and kisspeptin,and their cognate receptors in teleost reproduction
    (Frontiers in Endocrinology) (4), Article 24  doi: 10.3389/fendo.2013.00024

Staff

  • Kitahashi T, Parhar IS.
    Comparative aspects of kisspeptin gene regulation
    (General and Comparative Endocrinology) 181:197-202  doi: 10.1016/j.ygcen.2012.10.003
  • Kitahashi, T, Shahjahan,M, Parhar, IS (2013)
    Chapter 11: Hypothalamic Regulation of Pituitary Gonadotropins.
    In: Balasubramanian Senthilkumaran. Sexual Plasticity and Gametogenesis in Fishes, Nova Science Publishers
  • Shahjahan,M., Kitahashi, T., S Ogawa., Parhar IS
    Temperature differentially regulates the two kisspeptin systems in the brain of zebrafish
    (General and Comparative Endocrinology) 193 : 79-85
  • S Moriya, S Ogawa, Parhar IS
    GnRH Neuron Type-Specific Transcriptome Analysis by Laser Captured Single-Cell Microarray in the Medaka
    (Biochemical and Biophysical Research) 435  (4): 562-566  doi: http://dx.doi.org/10.1016/j.bbrc.2013.05.004
  • Satoshi Ogawa, Kai We Ng, Xiaoyu Xue, Priveena Nair Ramadasan, Mageswary Sivalingam, Shuisheng Li, Haoran Lin, Xiaochun Liu and Ishwar S. Parhar
    Thyroid hormone upregulates kiss2 gene in the nile tilapia, Oreochromis niloticus
    (Frontiers in Endocrinology) 4, article no: 184  doi: 10.3389/fendo.2013.00184
  • Ogawa S, Parhar IS (2013)
    Anatomy of the kisspeptin systems in teleosts
    General and comparative endocrinology 181, 169-174
  • IS Parhar (2013) Seventh Congress of the Asia and Oceania Society for Comparative Endocrinology. General and comparative endocrinology 181, 167

Collaborator

  • Q Wang, KWY Sham, S Ogawa, S Li, Parhar IS, CHK Cheng, X Liu, H Lin
    Regulation of the Two kiss Promoters in Goldfish (Carassius auratus) by Estrogen via Different ERα Pathways
    (Molecular and Cellular Endocrinology) 375 (1-2):130-139 doi: http://dx.doi.org/10.1016/j.mce.2013.04.023
  • S.Jirawat, S.Thanyaporn, T. Montakan, W.Wattana, C. Jittipan, H. Peter, Parhar IS, S.Prasert,S. Prapee
    Histological organization of the central nervous system and distribution of a gonadotropin-releasing hormone-like peptide in the blue crab, Portunus pelagicus
    (Cell and Tissue Research) 353 (3):495-510
  • Anukulthanakorn K, Malaivijitnond S, Kitahashi T, Jaroenporn S, Parhar I.
    Molecular events during the Induction of Neurodegeneration and Memory Loss in Estrogen-Deficient Rats
    (General and Comparative Endocrinology) 181:316-323  doi: 10.1016/j.ygcen.2012.07.034
  • Nilesh Kumar Mitra, Tiffanie Ee Wen Goh, Thalisha Bala Krishnan, Vishna Devi Nadarajah, Arun Kumar Vasavaraj, T Soga
    Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats
    (International Journal of Experimental Pathology) 6(8):1505-1515

2012

Students

  • Phang YL, Soga T, Kitahashi T, Parhar IS.
    Cloning and functional expression of novel cholesterol transporters ABCG1 and ABCG4 in gonadotropin-releasing hormone neurons of the tilapia
    (Neuroscience) 203: 39-49  doi: 10.1016/j.neuroscience.2011.12.016
  • Soga T, Dalpatadu SL, Wong DW, Parhar IS.
    Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice
    (Neuroscience) 30(218): 56-64  doi: 10.1016/j.neuroscience.2012.05.023
  • Soga T, Wong DW, Putteeraj M, Song KP, Parhar IS.
    Early-life citalopram-induced impairments in sexual behavior and the role of androgen receptor
    Neuroscience 225, 172-184

Staff

  • Ogawa S, Ng KW, Ramadasan PN, Nathan FM, Parhar IS
    Habenular Kiss1 Neurons modulate the Serotonergic system in the Brain of Zebrafish
    (Endocrinology) 153 (5):2398-2407  doi: 10.1210/en.2012-1062
  • Ogawa S, Ramadasan PN, Goschorska M, Anantharajah A, Ng KW, Parhar IS
    Cloning and Expression of Tachykinins and their association with Kisspeptins in the Brains of Zebrafish
    (Journal of Comparative Neurology) 520(13):2991-3012  doi: 10.1002/cne.23103
  • Parhar IS, Ogawa S, Kitahashi T
    Rfamide peptides as mediators in environmental control of GnRH Neurons.
    (Progress in Neurobiology) 98 (2):176-196  doi: 10.1016/j.pneurobio.2012.05.011

Book Chapters

  • Kitahashi, T, Shahjahan,M, Parhar, IS (2013)
    Chapter 11: Hypothalamic Regulation of Pituitary Gonadotropins.
    In: Balasubramanian Senthilkumaran. Sexual Plasticity and Gametogenesis in Fishes, Nova Science Publishers
  • Parhar IS (1997)
    GnRH in tilapia: three genes, three origins and their roles.
    In: Parhar IS, Sakuma Y (eds) GnRH neurons: gene to behavior. Brain Shuppan Publishing Co., Tokyo, pp 99-122
  • Parhar IS, Pfaff DW and Schwanzel-Fukuda M (1995)
    Comparative approach to the GnRH neuronal migration problem.
    In: Mogvilersky J., Bergada C (eds). Puberty: Basic and Clinical Aspects. Frontiers in Endocrinology, vol.10: 75-83
  • Parhar IS and Sakuma Y (1995)
    GnRH expression during development.
    In: Itakura T, Maeda T (eds) The Hypothalamus from basic to clinical neuroscience IV. Brain Shuppan Publishing Co., Tokyo, pp 1-19.
  • Parhar IS, Pfaff DW and Schwanzel-Fukuda M (1995)
    Genes and Behavior as studied through GnRH neurons: comparative and functional aspects.
    In: Libertun et al. (eds). Cellular and Molecular Neurobiology 15 (1): 107-116.
  • Pfaff DW, Schwanzel-Fukuda M, Parhar IS, Lauber AH, McCarthy MM and Kow LM (1994)
    GnRH neurons and other cellular and molecular mechanisms for simple mammalian reproductive behaviors.
    In: Bardin CW (eds). Recent Progress Hormone Research, Academic Press, New York, vol. 49: 1-25

Book Edited

  • Comparative biology of GnRH (molecules and receptors) (2002) Parhar IS (eds). Progress in Brain Research, Vol. 141, Elsevier, Amsterdam.
  • Comparative biology of GnRH neurons (1998) Moore FL, Henderson IW and Parhar IS (eds). Gen. Comp. Endocrinol. Vol. 112, pp 275-454, Academic Press, USA
  • GnRH neurons: gene to behavior (1997) Parhar IS and Sakuma Y (eds), pp 1-486, Brain Shuppan Publishing Co., Tokyo

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