Associate Professor Dr. Ong Chin Eng

Contact Details

B.Pharm(Hons), PhD(Pharmacology)
Associate Professor – Pharmacy
Head of School

Office: Building 2, Level 5, Room 45
Tel: +603 5514 4918
Fax: +603 5514 6364
Email: ong.chin.eng@monash.edu

Dr Ong completed his undergraduate studies in the Universiti Sains Malaysia, Penang and graduated with a Bachelor in Pharmacy (Hons) degree. He completed his one-year housemanship by serving as a trainee pharmacist in Hospital Ipoh. Soon after the housemanship, he was awarded the Australian Overseas Postgraduate Research Scholarship to undertake his PhD study at The Flinders University, Adelaide, Australia. Upon completion of his PhD, he joined the School of Pharmacy of the International Medical University as a Lecturer, and was later promoted to Senior Lecturer. He joined Monash University Malaysia as a Senior Lecturer in Pharmacy in March 2009 and was promoted as Associate Professor in 2013.

(A) TEACHING

SUBJECT CODESUBJECT
PAC 1111Introduction to Physiology
PAC 1132System Physiology
PAC 2182Basis of drug action II
PAC 2232Drug delivery and disposition
PAC 3552Community Engagement
PAC 4441Integrated therapeutics: Endocrinology and renal
PAC 4451Integrated Therapeutics: Dermatology and pain

(B)  AREAS OF EXPERTISE / RESEARCH INTEREST

  • Pharmacology
  • Drug metabolism
  • Cytochrome P450
  • Drug-drug interactions
  • Drug-herb interactions
  • Pharmacogenetics

(A)  SCHOLARLY JOURNALS

  1. Muthiah YD, Ong CE, Sulaiman SA and Ismail R (2016) Inhibition of human cytochrome P450 2C8-catalyzed amodiaquine N-desethylation: Effect of five traditionally and commonly used herbs. Pharmacognosy Research (in press)
  2. Tan BH and Ong CE (2016) The use of natural remedies to treat osteoarthritis. TANG 6:e1
  3. Pan Y, Tiong KH, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE (2014) In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity. Phytomedicine 21: 1645-1650.
  4. Ong CE and Pan Y (2014) Drug-herb interactions: mechanisms involved and clinical implications of five commonly and traditionally used herbs. TANG 4:e17
  5. Tiong KH, Mohammed Yunus NA, Yiap BC, Tan EL, Ismail R and Ong CE (2014). Inhibitory potency of 8-metoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential susceptibility due to different sequence locations of the mutations. PLoS One 9:e86230.
  6. Pan Y, Tiong KH, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE (2014). Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro. Journal of Natural Medicines 68: 402-406.
  7. Ong CE, Pan Y, Mak JW and Ismail R (2013). In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability. Expert Opinion on Drug Metabolism and Toxicology 9:1097-1113.
  8. Pan Y, Mak JW and Ong CE (2013). Heterologous expression of human cytochrome P450 (CYP) 2C19 in Escherichia coli and establishment of RP-HPLC method to serve as activity marker. Biomedical Chromatography 27: 859-865.
  9. Muthiah YD, Ong CE, Sulaiman SA, Tan SC and Ismail R (2012). In vitro inhibitory effect of Tualang Honey on cytochrome P450 2C8 (CYP2C8) activity. Journal of Pharmacology 64:1761-1769.
  10. Pan Y, Tiong KH, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE (2012). Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts. Journal of Ethnopharmacology 143: 586-91.
  11. Pan Y, Mak JW and Ong CE (2012). Development and validation of HPLC methods for the determination of CYP2D6 and CYP3A4 activities. Current Pharmaceutical Analysis 8: 219-224.
  12. Pang CY, JW Mak, Ismail R and Ong CE (2012). In vitro modulatory effects of flavonoids on human cytochrome P450 2C8 (CYP2C8). Naunyn-Schmiedeberg’s Archives of Pharmacology 385: 495-502.
  13. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE (2011). Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization. The Protein Journal 30: 581-91.
  14. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM and Ong CE (2011). In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. Journal of Natural Medicines 65: 440-447.
  15. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM and Ong CE (2011). In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. Chemico-Biological Interactions 190:1-8.
  16. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC and Ong CE (2011). In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). Journal of Ethnopharmacology 133: 881-887.
  17. Tiong KH, Yiap BC, Tan EL, Ismail R and Ong CE (2010). In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity. Xenobiotica 40: 458-66.
  18. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM and Ong CE (2010). In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. Journal of Ethnopharmacology 130: 275-283.
  19. Tiong KH, Yiap BC, Tan EL, Ismail R and Ong CE (2010) Functional characterization of cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22. Drug Metabolism and Disposition 38:745-51.
  20. Tiong KH, Yiap BC, Tan EL. Ismail R and Ong CE (2010). Molecular cloning and functional analysis of cytochrome P450 2A6 (CYP2A6). Asia Pacific Journal of Molecular Biology and Biotechnology 18: 351-357.

(B)  CONFERENCE PROCEEDINGS (REFEREED ONLY)

  1. Dong AN, Pan Y, Palanisamy UD, Ismail R and Ong CE. Functional characterization of amino acid mutations in cytochrome P450 2D6 (CYP2D6) variants CYP2D6*2 and CYP2D6*17. In: 19th International Conference on Cytochrome P450, Tokyo, 12-15 June 2015 
  2. Ong CE, Dong AN, Pan Y, Palanisamy UD and Ismail R. Functional characterization of cytochrome P450 2D6 (CYP2D6) allelic variants CYP2D6*10. In: Golden Helix Symposia: Next Generation Pharmacogenomics, Kuala Lumpur, 11-13 May 2015
  3. Tan BH, Pan Y, Palanisamy UD, Othman I, Yiap BC and Ong CE. In vitro modulatory effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 2C9 activity. In: 24th Singapore Pharmacy Congress, Singapore, 18-19 October 2014 
  4. Dong AN, Pan Y, Palanisamy UD, Ismail R and Ong CE. Functional characterization of cytochrome P450 2D6 (CYP2D6) allelic variants CYP2D6*2 and CYP2D6*17. In: Pharmacology & Physiology International Scientific Congress, Kuala Lumpur, 22-24 August 2014 
  5. Ong CE, Pan Y, Abd-Rashid BA, Ismail Z, Ismail R and Mak JW. Studies of in vitro modulatory effect of Labisia pumila on CYP1A2, CYP2A6 and CYP3A4. In: 10th International ISSX Meeting, Toronto, Canada, 30 September-3 October, 2013 
  6. Tan BH, Pan Y, Palanisamy UD, Othman I, Yiap BC and Ong CE. Effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 3A4 activity in vitro. In: 13th International Congress of Toxicology, Seoul, Korea, 30 June-4 July 2013 
  7. Dong AN, Tan BH, Siong WL, Pan Y, Palanisamy UD and Ong CE. Site-directed mutagenesis of human cytochromes P450 (CYPs): generation of common mutants of CYP2D6 and CYP2C19. In : International Conference on Advances in Medical Science, Kuala Lumpur, 16-18 April 2013 
  8. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE. In vitro effect of various herbal active constituents on cytochrome P450 2E1.  In : Malaysian Pharmaceutical Society Scientific Meeting, Kuala Lumpur, 31 October-2 November 2012 
  9. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW and Ong CE. Evaluation of the modulatory effect of Labisia pumila extracts on cytochrome P450 2C8 in vitro.  In : 19th MDO and 12th European ISSX Meeting, Noordwijk ann Zee, the Netherlands, 17-21 June 2012 
  10. Tan BH, Pan Y, Palanisamy UD, Othman I, Yiap BC, Ong CE. Diacerein for Osteoarthritis: Potential Drug-natural Compound Interaction with Human Hepatic Cytochrome P450 2D6. In : 26th Scientific Meeting of The Malaysian Society of Pharmacology and Physiology, Penang, 18-20 May 2012 
  11. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW  and Ong CE. Studies of in vitro modulatory effects of Labisia pumila on cytochrome P450 2C19.  In : Malaysian Pharmaceutical Society Scientific Meeting, Kuala Lumpur, 21-23 October 2011
  12. Tan BH, Pan Y, Palanisamy UD, Othman I, Yiap BC, Ong CE. In Vitro Modulatory Effects of Glucosamine and Chondroitin on Human Hepatic Cytochrome P450 2D6. In : Malaysian Pharmaceutical Society Scientific Meeting, Kuala Lumpur, 21-23 October 2011
  13. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW  and Ong CE. Evaluation of in vitro effects of various herbal active constituents on cytochrome P450 1A2. In: 25th Scientific Meeting of The Malaysian Society of Pharmacology and Physiology, Serdang, Selangor, 25-26 May 2011 
  14. Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW  and Ong CE. In vitro modulatory effects of Labisia pumila on cytochrome P450 2C9. In: 25th Scientific Meeting of The Malaysian Society of Pharmacology and Physiology, Serdang, Selangor, 25-26 May 2011

MEMBERSHIP IN ASSOCIATIONS AND INTERNATIONAL BODIES

  1. Member, the Malaysian Pharmaceutical Society

MEMBERSHIP IN INTERNATIONAL PROFESSIONAL BODIES

  1. Member, the International Society for the Study of Xenobiotics

No content

No content