Dr. Alan Yiu Wah Lee

Contact Details

BSc., PhD
Senior Lecturer

Office: Building 2, Level 5, Room 37
Tel: +603 5514 4417
Fax: +603 5514 6364
Email: alan.lee@monash.edu

Biodata

The long-term goal of Dr. Lee’s research team is to understand the functions of neuronal axon guidance molecules in the nervous systems during physiological and pathological conditions. His recent research interests include the role of guidance molecules in neuronal and glial differentiation, in cancer progression and in CNS regeneration. A combination of various approaches, ranging from cell and molecular biology, molecular genetics, animal models and controlled drug delivery are used in these studies.

Areas of Expertise

  1. Molecular genetics
  2. Molecular medicine
  3. Cell motility
  4. Neuronal axon guidance
  5. Brain cancer
  6. CNS regeneration

(A)  BOOK CHAPTERS

Lee, A. Y. “The involvement of guidance molecules in adult brain neurogenesis”. In Neurogenesis, Neurodegeneration and Neuroregeneration. Research Signpost, 2010. pp. 27-41


(B)  SCHOLARLY JOURNALS (REFEREED ONLY)

Law, J.W. and Lee, A.Y. (2012) The role of semaphorins and their receptors in gliomas. J. Signal Transduct.vol. 2012, Article ID 902854.
Li, X, Law, J.W, and Lee A.Y. (2012) Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. Oncogene31, 595-610.
Li, X. and Lee, A.Y. (2010) Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIα-mediated inactivation of Rac1 GTPase. J. Biol. Chem. 285, 32436-45.
Chong, K. W., Chen, M. J., Koay, E. S., Wong, B. S., Lee, A. Y., Russo-Marie, F., and Cheung, N. S. (2010) Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury. Neurosci. Letters 485, 129-133.
 Chew, J., Chen, M. J., Lee, A. Y., Peng, Z. F., Chong, K. W., He, L., Bay, B. H., Ng, J. M., Qi, R. Z., and Cheung, N. S. (2010) Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator. J. Cell. Biochem. 111, 1359-1366.
Tan, E.Y., Law, J. W., Wang, C.H. and Lee, A. Y. (2007) Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons. Pharm. Res. 24, 2297-2308.

Membership in Academic Editorial Committees

Name of Association/International BodyFrontiers in Neurotrauma
RoleReview editor
Duration of membership - Month/Year2010
Name of Association/International BodyToxicology and Applied Pharmacology
RoleReviewer
Duration of membership - Month/Year2013

Membership in International Professional Bodies

Name of Association/International BodySociety for Neuroscience
RoleMember
Duration of membership - Month/Year2002

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