Dr. Lee Chooi Yeng

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Contact Details

BSc.(Hons) Biochemistry, MSc. Pharmacy, PhD (Pharmacology)
Lecturer – Pharmacy


Office: Building 2, Level 5, Room 13
Tel: +603 5514 6314
Fax: +603 5514 6364
Email: chooi.yeng.lee@monash.edu

Biodata

Dr Lee Chooi Yeng joined Monash University Malaysia in November 2009 as a Lecturer for the Bachelor of Pharmacy degree program offered by the campus. She obtained her PhD from Universiti Malaya in 2008, and received post-doctoral training from the University of Shizuoka, Japan between 2008 and 2009. Dr Lee is actively involved in obesity research since 2008, where she investigates mechanisms that contribute to the development and manifestation of obesity and its associated co-morbidities, specifically, central neural mechanism and the role of neuropeptides in this context. Dr Lee serves as a reviewer for a number of high impact journals, and has received research grants and support from the pharmaceutical industry, government as well as private organisations.

Areas of Expertise

  1. Gastrointestinal pharmacology
  2. Gastrointestinal physiology
  3. Obesity
  4. Gut-brain axis

Academic Qualifications

Doctor of Philosophy (PhD)
InstitutionUniversiti Malaya
Year Awarded2008
 
Master of Science
InstitutionUniversiti Sains Malaysia                             
Year Awarded2004
 
Bachelor of Science
InstitutionUniversiti Kebangsaan Malaysia
Year Awarded2002

(A) SCHOLARLY JOURNALS (REFEREED ONLY)

CY Lee (2016). Glucagon-like peptide-1 formulation – the present and future development in diabetes treatment. Basic Clin Pharmacol Toxicol. 118: 173-180.
CY Lee (2015). Adenosine protects Sprague Dawley rats from high fat-diet- and repeated acute restraint stress-induced intestinal inflammation and altered expression of nutrient transporters. J Anim Physiol Anim Nutr 99: 317-325.
CY Lee and A Abizaid (2014). The gut-brain-axis as a target to treat stress induced obesity. Front Endocrinol 5: 117. 
KP McNamara and CY Lee (2014). Motivating undergraduate students via online learning to develop clinical competencies. Pharm Educ 14: 101-108.  
CY Lee (2014). Modulating specific central and peripheral pathways to effectively treat obesity. J Mol Genet Med S1: 007. 
CY Lee (2013). The effect of high fat-diet-induced pathophysiological changes in the gut on obesity: what should be the ideal treatment?  Clin Transl Gastroenterol 4: e39.
CY Lee (2013). Chronic restraint stress induces intestinal inflammation and alters the expression of hexose and lipid transporters. Clin Exp Pharmacol Physiol 40: 385-391.
CY Lee (2012). Quercetin/adenosine combination may induce insulin resistance in high fat diet-fed mice. Obes Res Clin Pract 6: e85-e90. 
CY Lee, HM Cheng, SM Sim (2007). Mulberry leaves protect rat tissues from immobilization stress-induced inflammation. BioFactors 31: 25-33. 
CY Lee, SM Sim, HM Cheng (2007). Systemic absorption of antioxidants from mulberry (Morus alba L) leaf extracts using an in situ rat intestinal preparation. Nutr Res 27: 492-497. 

(B) CONFERENCE PROCEEDINGS (REFEREED ONLY)

YZ Lee, IH Ooi, CY Lee (2014). Encapsulation of hydrophilic drug into PLGA-PEG-FOL nanoparticles by nanoprecipitation. 5th FIP Pharmaceutical Sciences World Congress, Melbourne, Australia.
CY Lee (2013). Depletion in intestinal antioxidants may contribute to high fat-diet- and psychological stress-induced pathophysiological changes in the intestine en route to obesity development. 2013 International Conference on Diabetes and Metabolism & 5th Scientific Meeting of the Asian Association for the Study of Diabetes, Seoul, Korea. 
CY Lee (2012). Effects of stress on intestinal nutrient absorption. International Conference of Physiological Sciences 2012, Suzhou, China. 
Palanisamy UD, Ling LT, Lee CY, Cheng HM, Radhakrishnan AK (2011). A potential anti-oxidant, anti-ulcer and anti-hyperglycemic agent in the rind of the rambutan, Nephelium lappaceum. III International Conference of Oxidative Stress Havana Redox, Havana, Cuba.
Lee CY, Suzuki A, Kobayashi A, Sakakibara H, Koyanagi A, Lin L, Sayama K, Shimoi K (2009). Consecutive isolation stress induced obesity, a view on the biochemical indices and liver gene expression. Annual Meeting of JSBBA, Fukuoka, Japan.  
Ling LT, Lim PL, Lee CY, Cheng HM, Radhakrishnan AK, Palanisamy U (2009). Rind of the rambutan, Nephelium lappaceum, a potential source of anti-ulcer agents and antioxidants. COSTAM/SFRR (Asean/Malaysia) International Workshop, Langkawi, Malaysia.
Lee CY, Kobayashi A, Sakakibara H, Kinae N, Shimoi K (2008). Fenofibrate prevents insulin resistance in high fat-diet treated mice by acting on SREBP-1 target genes. 1st International Conference on Health and Longevity Sciences, Shizuoka, Japan.
Lee CY, Cheng HM, Sim SM (2007). Antioxidants from mulberry leaves reduce peroxidation and inflammatory response in tissues of immobilisation stress-induced rats. 3rd International Conference on Polyphenols and Health, Kyoto, Japan. 

(C) CONFERENCE PROCEEDINGS (NON-REFEREED PUBLICATIONS INCLUDED)

CY Lee (2013). Development of effective and targeted treatment for obesity. BIT’s 11th Annual Congress of International Drug Discovery Science & Technology, Haikou, Hainan, China. 
TH Thet, N Ahmed, M Jasamai, CY Lee, K Kadir (2013). In silico search for steroidal based 11beta-hydroxysteroid dehydrogenase (type 1) inhibitor. BIT’s 11th Annual Congress of International Drug Discovery Science & Technology, Haikou, Hainan, China.   
CY Lee (2011). The role of dietary antioxidants in stress, inflammation and obesity. 2011 EPS Huhhot Animal Sciences Development Forum, Huhhot, Inner Mongolia, China.

Local Grants

TitleSuppressing appetite and body weight gain through delivery of glucagon-like peptide 1 (GLP1) to the brain using novel GLP1-loaded pH-sensitive inorganic nanoparticles. 
InvestigatorsLee Chooi Yeng, Iekhsan Othman, Ezharul Chowdhury
Funding (Start & End Year)2014-2017
Funding Body/OrganisationMOE (FRGS)
Funding AmountRM120,000
 
TitleDevelopment of selective 11beta-hydroxysteroid dehydrogenase (type 1) inhibitors as potential therapeutic agents for obesity. 
InvestigatorsThet Thet Htar, Lee Chooi Yeng, Malina Jasamai, Khalid Abdul Kadir  
Funding (Start & End Year)2012-2014
Funding Body/OrganisationMOSTI (eScience Fund)
Funding AmountRM275,000
 
TitleStudy on the efficiency and effectiveness of newly synthesised nanoparticles in targeting and treating glioblastoma using in vitro and in vivo models. 
InvestigatorsLee Chooi Yeng
Funding (Start & End Year)2012
Funding Body/Organisation                                              MAKNA and Academy of Science Malaysia
Funding AmountRM30,000

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