Dr. Nafees Ahemad

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Contact Details

B. Pharm (Pune University, INDIA), M. S. (Pharm) (NIPER, Mohali, INDIA), PhD (NIPER, Mohali, INDIA)
Senior Lecturer (Medicinal Chemistry)

Office: Building 2, Level 5, Room 14
Tel: +603 5514 5883
Fax: +603 5514 6364
Email: nafees.ahemad@monash.edu

Biodata

Dr. Nafees has joined MONASH University Malaysia (MUM) on September 2012. He obtained M.S. (Pharm) and PhD in Natural Products chemistry/Medicinal Chemistry from National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. He worked on total synthesis of natural products, synthesis of new chemical analogues for discovery of new anti-HIV agents based on natural products templates. Before joining MUM as lecturer, he was a Postdoctoral Research Fellow in Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM) Penang. His current areas are computational based rational design of new drug candidates for HIV-1, dengue and other therapeutics.

Areas of Expertise

  1. Computer Aided Drug Design and synthesis of New Chemical Entities (NCE)
  2. Lead optimization to explore the functions of biologically active natural products as well as synthetic compounds
  3. Total synthesis of biologically active natural products
  4. Molecular docking and computational simulation studies

Academic Qualifications

Doctor of Philosophy (PhD)
InstitutionNational Institute of Pharmaceutical Education and Research (NIPER), India
Year Awarded2011
 
Master of Science (Pharm)
InstitutionNational Institute of Pharmaceutical Education and Research (NIPER), India
Year Awarded2005
 
Bachelor of Pharmacy
InstitutionUniversity of Pune
Year Awarded2003

(A)  BOOK CHAPTERS

“Chapter 19: Ajwain  (Trachyspermum ammiL.) Oils” Sirajudheen Anwar, Nafees Ahmed, Sofiane Habibatni and Yousef Abusamra., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 181-192.
 “Chapter 29: Bitter Orange (Citrus aurantiumL.) Oils” Sirajudheen Anwar, Nafees Ahmed, Antonio Speciale, Francesco Cimino and Antonella Saija., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 259-268.
“Chapter 55: Jasmine  (Jasminum sambac L,Oleaceae) Oils” Nafees Ahmed, Yousef A. Hanani, Shabana Y. Ansari and Sirajudheen Anwar., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 487-494.
“Chapter 66: Myrtle  (Myrtus communis L.) Oils” Sirajudheen Anwar, Nafees Ahmed, Nasir Al Awwad, Shabana Y. Ansari and Mohamed E. Wagih., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 581-592.
“Chapter 80: Saffron Crocus (Crocus sativus) Oils” Nafees Ahmed, Sirajudheen Anwar, Said Saleh Alsokari, Shabana Y. Ansari and Mohamed E. Wagih., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 705-714.


(B)  SCHOLARLY JOURNALS

Protein thaw loss in meat systems: Biochemical influence towards meat authentication of fresh versus thawed. Saralla Nathan, Md. Ezharul Hoque Chowdhury, Anuar Zaini Md Zain, Iekhsan Othman, Sharifah Binti Syed Hassan, Nafees Ahmed*. International Food Research journal.  2016, Accepted in Press.
Influence of YouTube videos on the learning of tablet-and capsule-formulation by Malaysian pharmacy students: A pilot study. Saravanan Muniyandy, Ng Khuenyen, Christina Gertrude Yap, Moriya Shogo, Nafees Ahemed, Md Ezharul Hoque Chowdhury,Ahmad Farouk Musa. Pharmacy Education, 2015; 15 (1) 248 – 251.
Synthesis, Biological Evaluation and Molecular Docking Studies of Tricyclic Guanidine Derivatives for Anti-Malarial Activity.”Nafees Ahmed, Shabana I. Khan, Kamlesh K. Bhutani. Asian Pac J Trop Dis 2014; 4(3): 233
Inhibitory Potency of 8-Methoxypsoralen on Cytochrome P450 2A6 (CYP2A6) Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential Susceptibility Due to Different Sequence locations of the Mutations. Kai Hung Tiong, Nafees Ahemad, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail, and Chin Eng Ong. PLOSONE 2014, 9(1), 1-8.
Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities. N. Ahmed, K. G. Brahmbhatt, S. I. Khan, M. Jacob, B. Tekwani, S. Sabde, D. Mitra, I. P. Singh, I. A. Khan, K. K. Bhutani. Chem. Biol. Drug Des. 2013; 81: 491-498.
Anti-HIV activity of Indian medicinal plants. S. Sabde, H. S. Bodiwala, A. Karmase, P. Deshpande,  A. Kaur, N. Ahmed, S. K. Chauthe, K. G. Brahmbhatt, R. U. Phadke, D. Mitra, K. K. Bhutani, I. P. Singh. J. Nat. Med. 2011, 65 (3-4), 662-669.
Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water. N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani. J. Heterocyl. Chem. 2011, 48, 237-240.
Synthesis and evaluation of β–carboline derivatives as inhibitors of human immunodeficiency virus. K. G. Brahmbhatt, N. Ahmed, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Bioorg. Med. Chem. Lett. 2010, 20, 4416-4419.
Total Synthesis of (±) Batzelladine K: A Biomimetic Approach. N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani. Synthesis 2010, 15, 2567-2570.
Synthesis and Anti-HIV Activity of Alkylated Quinoline 2,4-diols.” N. Ahmed, K. G. Brahmbhatt, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Bioorg. Med. Chem. 2010, 18, 2872-2879. (Among Top 25 most downloadable research papers).
Aromatization and chemoselective alkylation of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and its derivatives.” K. G. Brahmbhatt, N. Ahmed, I. P. Singh, K. K. Bhutani. Tetrahedron Lett. 2009, 50, 5501–5504.
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.” S. B. Bharate, S. I. Khan, Nafees. A. M. Y, S. K. Chauthe, M. R. Jacob, B. L. Tekwani, I. A. Khan, I. P. Singh. Bioorg. Med. Chem. 2007, 15, 87–96.

(C)  PATENTS

“Novel anti-HIV compounds.” K. K. Bhutani, N. Ahmed, K. G. Brahmbhatt, I. P. Singh, D. Mitra, S. Sabede. Application No.1556/DEL/2009 28-07-2009.
“Novel alkylated derivatives of quinoline 2,4-diol with anti-HIV activity.” K. K. Bhutani, N. Ahmed, K. G. Brahmbhatt, I. P. Singh, D. Mitra, S. Sabede. Application No.1557/DEL/2009 28-07-2009.


(D)   CONFERENCE PROCEEDINGS (REFEREED ONLY)

Influence of Freeze-thaw Cycles on Protein Integrity and Quality of Chicken Mea. Nafees Ahmed*,  Nur  Izyani Kamaruzman,  Saralla Nathan, Mohd. Ezharul  Hoque Chowdhury, Anuar Zaini Md Zain, Iekhsan Othman, Sharifah Binti Syed Hassan. International Conference on Halal Research 26-27 October, 2015, Istanbul, Turkey.
“Synthesis,biological activity and molecular docking studies of tricyclic guanidine derivatives for anti-malarial activity.” Nafees Ahmed, Shabana Khan, Kamles K Bhutani. 1st International Conference on Molecular Diagnostics & Biomarker Discovery, 23-25 October 2013 organized by INFORMM, USM,Penang (Best Oral Presentation Award)
“Design and synthesis of canthin-6-one amino acid conjugates for anti-HIV activity.” K. G. Brahmbhatt, V. M. Gohil, N. Ahmed, I. P. Singh, K. K. Bhutani. New Developments on Drug Discovery in Natural Products and Traditional Medicines II (DDNPTM) 20-24 November 2010, NIPER, Mohali, India.
“Synthesis of tricyclic guanidine analogues of batzelladine K for anti-HIV activity.” N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani. New Developments on Drug Discovery in Natural Products and Traditional Medicines II (DDNPTM) 20-24 November 2010, NIPER, Mohali, India.
“Total synthesis of (±) Batzelladine K and its derivatives for anti-HIV activity.” N. Ahmed, K. G. Brahmbhatt, K. K. Bhutani. ESF-COST High-Level Research Conference on Natural Products Chemistry, Biology and Medicine III, Acquafredda di Maratea, Italy, 5-10 September 2010.
“Synthesis of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and 1-methyl-β-carboline-3-carboxylic acid derivatives for anti-HIV activity.” K. G. Brambhatt, NAhmed, K. K. Bhutani. Tenth Tetrahedron Symposium, 22-25 June 2010, Peking University, Beijing, China.
“Synthesis and Anti-HIV Activity of C-3 Dialkylated derivatives of Quinoline 2,4-diols.” N. Ahmed, K. G. Brahmbhatt, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Drug Discovery in Natural Products and Traditional Medicines (DDNPTM) Nov. 2008, NIPER, S.A.S. Nagar, Mohali, India.
“Design and synthesis of β-carboline derivatives for anti-HIV activity.” K. G. Brahmbhatt, N. Ahmed, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Drug Discovery in Natural Products and Traditional Medicines (DDNPTM) Nov. 2008, NIPER, S.A.S. Nagar, Mohali, India.

Local Grants

Title Synthesis of 5-azapurine derivatives as new modulators of purinergic receptors
Investigators Nafees Ahemad, Chow Sek Chuen, Anton Dolzhenko, Iekhsan Othman
Funding (Start & End Year) 2015-2018
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 152, 000
 
Title Influence of chicken thawing process on protein integrity and activation of key cell signaling molecules in Halal vs Non-Halal meat
Investigators Nafees Ahemad, Ezharul Haque, Iekhsan Othman, Anuar Zaini
Funding (Start & End Year) 2013-2015
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 96, 000
 
Title The role of carboxypeptidase B1, an Aedes aegypti midgut protein in DENV infection and replication via interaction with the viral envelope (E) protein.
Investigators Sharifa Binti Hussain Syed, Nafees ahmed
Funding (Start & End Year) 2014-2016
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 138, 000
 
Title Cytochrome P450 3A4 (CYP3A4) – probing mechanisms of genetic polymorphism by assessing enzyme kinetics, ligand binding and computational modeling for three common genetic variants CYP3A4*2, CYP3A4*3 and CYP3A4*17
Investigators Ong Chin Eng, Nafees Ahemad, Uma Devi, Pan Yan, Malikarjuna, Yiap Beon
Funding (Start & End Year) 2014-2016
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 142, 000
 
Title Identification of the pharmacophoric groups of an ideal GPER-1 ligand and its interaction mechanism with the receptor in breast cancer cells
Investigators Thet Thet Htar, Nafees Ahemad, Rakesh Naidu, Chua Lay Hong
Funding (Start & End Year) 2015-2018
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 145, 000
 
Title Evaluating the mechanism of maslinic acid in monocyte recruitment and foam cell macrophage formation: Regulatory effect of NF-κB and Nrf2
Investigators Yap Wei Hsum, Nafees Ahemad, Lim Yang Mooi, Phelim Yong Voon Chen
Funding (Start & End Year) 2015-2018
Funding Body/Organisation Ministry of Education Malaysia (FRGS)
Funding Amount RM 142,000

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