Dr B Saatheeyavaane Bhuvanendran Pillai
Jeffrey Cheah School of Medicine & Health Sciences
Tel: +603-5514 6250
Office: Room 3-3-05
ORCID ID: orcid.org/0000-0002-3889-0163
Dr B Saatheeyavaane is an assistant lecturer in Neuroscience at Brain Research Institute Monash Sunway (BRIMS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia since 2019. She received her BSc from AIMST University in 2008 and then obtained her PhD from Monash University in 2019. Her PhD research project dealt with the evaluation of the neuroprotective effect of natural compound against Alzheimer’s disease by targeting the multifactorial condition and further develop into drug for treatment and/or prevention of AD. The approach used in her study was comprehensive ranging from biochemical, behavioural, pharmacological and molecular studies. Based on her PhD research work, she has published in internationally renowned journals such as Frontiers in Pharmacology and Frontiers in Neuroscience.
Bachelor of Science (B.Sc. Hons) in Biotechnology, AIMST University, Malaysia
PhD in Medicine (Neuroscience), Jeffery Cheah School of Medicine and Health Sciences, Monash University, Sunway Campus.
2011- 2014: Senior Technical Officer, Brain Research Institute of Monash University Sunway campus (BRIMS)
2010-2011: Research Officer, Institute for Medical Research (IMR)
2008-2010: Research Officer, Research in Molecular Medicine (INFORMM) USM
- Member – Malaysian Society of Neurosciences
- Member – Asian-Pacific Society for Neurochemistry
- Member – Neuro Malaysia Society
Neuropharmacology, Alzheimer’s disease, Neuroinflammation
Saatheeyavaane Bhuvanendran, Nur Aziah Hanapi, Nafees Ahmed, Iekhsan Bin Othman, Siti Rafidah Yusof, Mohd. Farooq Shaikh. Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies. Front Neurosci. doi: 10.3389/fnins.2019.00495 (2019)
Saatheeyavaane Bhuvanendran, Yatinesh Kumari, Iekhsan Bin Othman, Mohd. Farooq Shaikh. Amelioration of cognitive deficit by embelin in a scopolamine-induced Alzheimer’s disease-like condition in a rat model. Front. Pharmacol. doi: 10.3389/fphar.2018.00665 (2018)
Alina Arulsamy, Yogini S Jaiswal, Bey Hing Goh, Saatheeyavaane Bhuvanendran, Thaarvena Retinasamy, Yatinesh Kumari, Iekhsan Othman, Leonard L Williams, Mohd Farooq Shaikh. Neuroactive drugs–A perspective on drugs of synthetic and medicinal plants origin. Pharm Pharmacol Int J. 2018; 6(6):422‒430.
Uday Kundap, Saatheeyavaane Bhuvanendran, Yatinesh Kumari, Iekshan Othman and Mohd Farooq Shaikh. Plant derived phytocompound, Embelin in CNS disorders: A systematic review. Front. Pharmacol. 2017; 8(76). doi: 10.3389/fphar.2017.00076
Maelinda Daker, Saatheeyavaane Bhuvanendran, Munirah Ahmad, Kenzo Takada and Alan Soo-Beng Khoo. Deregulation of lipid metabolism pathways genes in nasopharyngeal carcinoma cells. Molecular Medicine reports Vol 7: 731-741. 2013
Ang Lim Chua, Ismail Aziah, Prabha Balaram, Saatheeyavaane Bhuvanendran, Amy Amilda Anthony, Siti Norazura Mohmad, Norhafiza M. Nasir, Haslizai Hassan, Rochman Naim, Lila P. Meran, Hani M. Hussin and Asma Ismail. Identification of Carriers Among Individuals recruited in the Typhoid Registry in Malaysia using Stool culture, Polymerase Chain Reaction and Dot Enzyme Immunoassay as Detection Tools. Asia-Pacific journal of Public Health XX(X) 1-9 (2012)
Saatheeyavaane Bhuvanendran, Hani M. Hussin, Lila P. Meran, Amy A. Anthony, Leilei Zhang, Lauranell H. Burch, Kia K. Phua, Asma Ismail, Prabha Balaram. Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia. Microbes and Infection Vol.13 (2011) 844-851
Bhuvanendran, S., Kumari, Y., Othman, I. and Shaikh, M. F. (2018) - Neuroprotective effect of Embelin in primary rat hippocampal culture model of neurotoxicity. EMBO Workshop on Neural Development, Taipei, Taiwan
Bhuvanendran, S., Kumari, Y., Othman, I. and Shaikh, M. F. (2016) - Memory enhancing effect of embelin against scopolamine-induced amnesia in Sprague Dawley rats. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00164.
Kundap. U. P, Bhuvanendran, S., Kumari, Y. and Shaikh, M. F. (2016) - Development of a zebrafish model for epilepsy and antiepileptic drugs induced cognitive dysfunction. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00169.
Bhuvanendran, S., Retinasamy, T., Shaikh, M. F., Kumari, Y., Othman, I. and Hassan, Z. (2015)- Pharmacological evaluation of phytocompound Embelin, derived from Embeliaribes in Alzheimer’s disease using chronic cerebral hypoperfusion rats - CDR Mini Symposium on Drug Addiction and Neurodegeneration, Sains@USM, Bukit Jambul, Penang, Malaysia (4 - 6 November 2015).
Retinasamy, T.,Bhuvanendran, S., Shaikh, M. F., Kumari, Y., Othman, I.,Hing, G. B., Shah, A. M., Shah, A. and Hassan, Z. (2015)- The Effect of EthanolicOrthosiphonstamineus Extract on Learning & Memory in Chronic Cerebral Hypoperfusion Induced Cognitive Impairment in rats- CDR Mini Symposium on Drug Addiction and Neurodegeneration, Sains@USM, Bukit Jambul, Penang, Malaysia (4- 6 November 2015).
Received travel grant award (NTD 17 500) for EMBO Workshop on Neural Development, 02-06 March 2018, Taipei, Taiwan
Received travel grant award and selected as APSN-ISN Neuroscience School 2016 delegate for APSN-ISN School 2016, UPM, Malaysia (Basic Techniques in in Vitro Neural Differentiation from Stem Cells)
Innovation and Patents
Bronze medal at PECIPTA 2017, an International Conference and Exposition on Inventions by Institutions of Higher Learning, Malaysia, for the project entitled “NP-A as a Memory Enhancer and Potential Molecule for Neurodegenerative Diseases”.