Dr Christina Gertrude Yap

Senior Lecturer

Jeffrey Cheah School of Medicine & Health Sciences

Email: christina.yap@monash.edu
Tel: +603 5514 5829
Office: Room 3-2-13

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Profile Summary

Dr Christina Gertrude Yap is Senior Lecturer in Metabolic Medicine at Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia since 2012.

She obtained her PhD from Monash University and for her PhD research project, she explored candidate early predictors for diabetic nephropathy. Her hypothetical candidate early predictor for diabetic nephropathy risk is CYP2E1. In her post-doctoral projects, she developed a targeted proteomic approach to quantitate CYP2E1 from human blood samples and assessed the applicability of this analytical method in clinical practice.

Her research interests are early biomolecules in the development of metabolic syndromes, and drug metabolizing enzymes.

Currently, she teaches Physiology and Pharmacology for the MD and Bachelor of Pharmacy courses.

Qualifications

  • Diploma in Medical Laboratory Technology
    Majoring in Pharmacology and Physiology (Double Major)
    School of Medical Sciences, Universiti Sains Malaysia, Pulau Pinang.
  • Bachelor of Biomedical Sciences (Honors)
    Faculty of Medicine, University Malaya, Kuala Lumpur.
  • Masters in Medical Sciences
    Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur
  • PhD in Medicine (Medical Biochemistry and Molecular Biology)
    Jeffery Cheah School of Medicine and Health Sciences, Monash University, Sunway Campus.
  • Graduate Certificate in Higher Education GCHE (Monash)

Working Experience

2012- 2018: Senior Lecturer, Jeffery Cheah School of Medicine and Health Sciences, Monash University, Kuala Lumpur

2010-2012: Assistant Lecturer, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Kuala Lumpur

2005-2007: Lecturer, School of Pharmacy, International Medical University, Kuala Lumpur

1993-2005: Medical Technologist, Department of Physiology, School of Medicine, University of Malaya

1990-1993: Medical Technologist, Subang Jaya Medical Center, Selangor

Affiliations

  • Member – Malaysian Society of Physiology and Pharmacology
  • Member – Monash University Malaysia Academic Staff Association (MUMASA)
  • Member – Malaysian Scientific Association

Research Interests

  • Pharmacokinetics and xenobiotic interaction with drug metabolizing enzymes.
  • Development of early biomarkers in diabetic nephropathy.
  • Translational studies of diabetic nephropathy.
  • Teaching & Learning methods in medical education.

Research Projects

2013 to date – Research projects on Pre diabetes, Diabetes, Obesity and Metabolic syndrome

2007-2013 – Early Predictors of Diabetic Nephropathy. (PhD Thesis Project)

2005 – Effects of “Ulams” on drug metabolizing enzymes.

2003 – Effects of Citrus grandis crude extracts on CYP2C19 and CYP3A4 activities.

2001 – Molecular cloning of p22 antigenic surface protein of Toxoplasma gondii

1997-1998 – Drug abuse screening among psychotic patients (from wad 5UHUM)

1997-1998 – Screening for drug abuse among Immigrant workers.

1997 – Dr Christina was a member of UNU (United Nations University)
Project:  “Environmental Monitoring in the Asian Region”.
Activity for 1997: Detection for Organotins in fish and VOC (Volatile organic compounds) in coastal waters.

1997 – Investigation of Cathinone as compliance studies in Psychotic patients.

1997 – Involved in bioavailability and bioequivalence studies of nifedipine.

Current and previous academic responsibilities

2011 to date

  • Physiology Lecturer: Year 1 and Year 2 MBBS course.
  • Facilitator: PBL sessions for Year 1 and 2 MBBS course
  • Histology Tutor: Year 1 and Year 2 MBBS course
  • Student Project Cases (SPC) Tutor: Year 2
  • Pharmacology & Pharmacology Lecturer: Years 1, 2, 3 and 4;B. Pharmacy course
  • Facilitator: IPE session Year 2 Pharmacy and MBBS students
  • HDR supervision (PhD)

1993 – 2005

  • Preparation and demonstration in practical classes for MBBS, BDS, pharmacy courses.
  • Physiology and Pharmacology lectures for BPharm students.
  • PBL Facilitator for BPharm students.

Leadership roles

2018 Coordinator for Hematology, MBBS course, JCSMHS

2018 Coordinator for Physiology, MBBS course, JCSMHS

2017 Coordinator for Physiology, MBBS course, JCSMHS

2005 Coordinator for Cancer chemotherapy unit, School of Pharmacy, IMU, PJ

Administrative responsibilities

  • Panel of interviewers for MBBS new student selection
  • Panel of interviewers for new academic staff selection
  • MBBS course marketing events.

Publications

Christina GY, Rakesh N, Kim DJ, Srinivasa RS, Narendra P. Pleiotropic effects of metformin in managing type 2 diabetes and metabolic syndrome: evidences from experimental mouse model. Biomedical Research 2018; 29(17);3323-3335. Publication in progress.

Ahmad FM, Xian PC, Christina GY, Jeswant D, Rusli N. Does diabetes mellitus increase the mortility risk in coronary artery disease patients undergoing coronary artery bypass grafting surgery at the National Heart Institute of Kuala Lumpur? Journal of Diabetes, Metabolic Disorders & Control. 2018;5(4):141-144.

Targeted CYP2E1 quantification and its correlation to currently acceptable clinical biochemical indices. Journal of Biological Research Thessaloniki2016; 23:15. DOI: 10.1186/s40709-016-0052-92016;23:15.

Influence of YouTube videos on the learning of tablet-and capsule-formulation by Malaysian pharmacy students: A pilot study. Pharmacy Education, 2015; 15 (1) 248-251.

Christina GY, A. Zaini, I. Othman. CYP2E1 level in peripheral lymphocytes correlates with early pathogenesis of diabetic nephropathy. Biomedical Research2013: 24(1):153-163.

Christina GY., R Hussein, Z. Mohamed., A.M. Mustafa.Activity of CYP1A2 in smokers and non-smokers using Caffeine as a test substance. Second National Conference on Medical Sciences. June 1996. (Proceeding).

Hwee-Ming Cheng, Christina GY.“Natural B-2-Glycoprotein I-independent anticardiolipin antibodies are not”STROKE May 1996, 27(5), p. 1007-1008.

Shahimi, M.M., A.R.Tariq, Christina GY., C.K. Bik, S. Suhaimi. Effects of the water extract of Stevia rebaudiana (Linn) on insulin release in isolated rat pancreas.Mal. J. Med. Lab. Sci. 1995; 12 (1); p.25-28.

Shahimi, MM., AR Tariq. Christina GY, CK Bik, S. Suhaimi. Effects of the Ethanolic extract of  Tinospora crispa on insulin release in isolated rat   Pancreas. Seminar Kimia Sebatian Semulajadi Ke-11: June 1995, Uni Mas Sarawak. (Proceeding)

Hwee-Ming Cheng, Christina GY. Cryptic autoantibodies to cell membrane phospholipids unveiled by heat-inactivation of sera.42nd. National Clinical Pathology Congress JAPAN 1995: p290 (Proceeding).

Christina GY, MD Lukmi Ismail, Nik Aziz Sulaiman, Shahimi MM, Kim Kah Hwi, Hassan Yaacob, Nancy Yeap. Cardiac Glycocide-like activity of the Malaysian dart poison (Latex of Pokok Ipoh). Mal. J. Med. Lab. Sci. 1994; 11(2); p71 (Abstract)

Christina GY, Shahimi MM, Hassan Yaacob.The Effects of Sea Cucumber Water Extract on writhing induced by acetic acid in mice. Journal of Biosciences, Vol 5, Issue 1&2, 1994.

Research Grants

2016
FRGS (MOHE) grant
Project Title: Neuroprotective and antioxidative nature of environment enrichment   exposure on diabetic and stressed rat hippocampus and identification of associated molecular pathways.
Research Role: Co-Researcher.
Amount: RM100K

2012
MOSTI (eScience Fund)
Project Title: Application of CYP2E1 as a clinical tool to monitor progression of diabetes and its complications.
Research Role: Principle Investigator.
Amount: RM347,000

2011
Nano fund Fasa1/2011 (MOSTI)
Project Title: Systemic Toxicity Analysis of Nano delivery Drug System
Research Role: Co-Researcher.
Amount: RM90,000

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Awards

  • Evaluation of CYP2E1 Gene Expression in Diabetic Nephropathy using Quantitative Real Time PCR.
    14th Biological Science Congress 10th-12th Dec. 2009, Chulalongkorn University, Bangkok, Thailand.    
    Prize awarded: Best Poster Presentation.
  • Targeted CYP2E1 quantification: Research to clinical application.
    5th World Congress on Diabetes and Metabolism. Nov. 3rd-4th, 2014, Las Vegas, USA.
    Prize awarded: Best Poster Presentation.
  • Endogenous molecules as candidate early indicator for type 2 diabetes.
    2nd World Congress on Clinical Trials in Diabetes, 27-28th November 2017, Berlin, Germany.
    Prize awarded: Best Poster Presentation
  • Endogenous molecules as candidate early indicator for type 2 diabetes.
    Monash CSJB research week 2017.
    Prize awarded: (Poster and oral presentation by year 4 MBBS student)-Second runner up.
  • The anthropometrics, cardio-metabolic health and oral microbiomes of an indigenous tribe.
    Monash CSJB research week 2017.
    Prize awarded: (Poster and oral presentation by HDR student)- First prize.

Presentation at Conferences

  • Christina GY, Ahmad FM, Xian PC, Jeswant D, Rusli N. Diabetes Mellitus Increase Mortality Risk in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting Surgery. 3rd World Congress on Clinical Trials in Diabetes, 3rd - 4th December 2018, Vienna, Austria.
  • Christina GY, A. Zaini, Arun PM. Endogenous molecules as candidate early indicator for type 2 diabetes. 2nd World Congress on Clinical Trials in Diabetes, 27-28th November 2017, Berlin, Germany.
  • Christina GY, Narendra P, Rakesh N, Kim DJ. Dual effectiveness of metformin in treating obesity and diabetes in mouse model. International Conference on Metabolic Syndrome, 17-18th October 2016, Rome, Italy.
  • Christina GY, A. Zaini, I. Othman Optimized LC/MS/MS quantification of CYP2E1: Research to clinical application. Mass Spectrometer Conference 28-29th Oct.2015, Biopolis, Singapore.
  • Christina GY, A. Zaini, I. Othman Targeted CYP2E1 quantification: Research to clinical application. 5th World Congress on Diabetes and Metabolism.  Nov. 3rd-4th, 2014, Las Vegas, USA.
  • Christina GY, A. Zaini, I. Othman. Diabetic nephropathy: old pathways, new candidate early risk predictors. IDF-WPR Congress 2012, 24-27th Nov, Kyoto, Japan.
  • Christina GY, A. Zaini, I. Othman. Correlation of CYP2E1 expression elevation with extent of   glycemic control in comparison to traditional clinical markers for diabetic nephropathy. ADS/ADEA Scientific Conference, 28th-31st August 2012 Gold Coast Convention Center, Brisbane, Australia.
  • Christina GY, A. Zaini, T.Y. Tee, M. Vanessa, L.S. Teh. Be Assured of Reliable HbA1c Results. Diabetes Asia Conference, 6-10th Oct 2011, Sunway Convention Center, Selangor.
  • Christina GY, A. Zaini, I. Othman, BT. Teh, CM. Wong. Evidences of CYP2E1 as a possible early predictor for diabetic Nephropathy. Diabetes Asia Conference 5-10th Oct. 2010, Borneo Convention Center, Kuching, Sarawak.
  • Christina GY, A. Zaini, I. Othman, BT. Teh, CM. Wong.  A Gene Expression Signature as an Early Predictor of Diabetic Nephropathy. ADS/ADEA Scientific Conference 1-4th Sept 2010, Sydney Convention Center.
  • Christina GY, A. Zaini, I. Othman, BT. Teh, CM. Wong. Evaluation of CYP2E1 Gene Expression in Diabetic Nephropathy using Quantitative Real Time PCR. 14th Biological Science Congress 10th-12th Dec. 2009, Chulalongkorn University, Bangkok, Thailand.
  • Christina GY, A. Zaini, I. Othman, BT. Teh, CM. Wong. Lymphocytic CYP2E1 – A possible early predictor for diabetic nephropathy. Diabetes Asia Conference , 8-12th Oct. 2009 Sunway Convention Center, Selangor.
  • Christina GY, Z. Mohamed and Ruby Husain. A Validated Assay for Assessing CYP2C19 and CYP3A4 activities simultaneously. International Conference in Health Science. 6th -8th May 2005, Sunway Convention Center, Selangor.
  • Christina GY, Z. Mohamed and Ruby Husain. Effects of Citrus grandis (Pummelo) Juice and its crude extracts on CYP2C19 and CYP3A4 activities. International Conference in Health Science. 6th -8th May 2005, Sunway Convention Center, Selangor.
  • Christina GY, Z. Mohamed and Ruby Husain. 5’hydroxy – omeprazole formation predominantly but not exclusively involves CYP2C19. 20th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology. 25-27th April 2005, Hotel Equatorial Penang.
  • Herman RB, Christina GY, Voo. YP, Mustafa AM. Hussain, R., and Lang C.C. Determination of plasma noradrenaline in humans using a novel gas chromatograph-mass spectrometer (GCMS) method. Joint 14th. Scientific Meeting of the Malaysian Society of Pharmacology & Physiology- Cardiac Rehabilitation Conference and Cardiovascular Counseling Workshop, May 1999, Penang, Malaysia.

Trainings

  • 1997 – Attended a workshop and training on the use of GCMS (Gas Chromatography Mass Spectrometry); Organized by Shimadzu Asia Pacific held at their head office in Singapore on 25th Feb - 1st Mar 1997.
  • 2001 – Fundamental of Atomic Absorption Spectrophotometer on 29th May 2001 held at Shimadzu (Asia Pacific) Pte Ltd, Singapore.
  • 1989 – Liquid Chromatography (HPLC) in the detection of Quinine and submitted a dissertation as practical fulfillment for the Diploma in Medical Laboratory Technology.
  • 1989 – Carried out an Elective project in Anesthesia and , a report. This was also as partial fulfillment for the Diploma in Medical Laboratory Technology.
  • 1990 – Involved in some research activities of the academic staff and one of these research programs was documented by the ‘BEYOND 2000’ television program in September 1990.
  • 2001 – Ventured to a project titled “Molecular cloning of Toxoplasma gondii p22 surface coat protein”, and submitted a thesis as partial fulfillment for the Bachelor of Biomedical Sciences degree programme.
  • 2009 – Attended a workshop in the Microarray Technology at the Malaysian Genome Institute (MGI), Bangi, Selangor.
  • 2010 – Attended a course and workshop for real time PCR organized by Chemopharm Sdn Bhd.

Participation in continuing education

  • Monash Research Forum, 22nd – 23rd July 2008, Monash University, Sunway Campus, Malaysia.
  • Foundations for Effective Teaching CEED (Continuing Education Excellence Development) Module, 9 Jan – 16 Feb, 2017, Monash University Malaysia.
  • Bio Linux-NGS workshop 20-21 Nov 2017, School of Science, Monash University Malaysia, Kuala Lumpur.
  • EDEXIN (Educational Excellence and Innovation) Conference, 13-14 December 2017, PJ Hilton, Kuala Lumpur.
  • 3rd National Pain Free Conference, 5-6 September 2018, Putrajaya, Kuala Lumpur.