Dr Faizul bin Jaafar

Assistant Lecturer

Jeffrey Cheah School of Medicine & Health Sciences

Email: faizul.jaafar@monash.edu
Tel+603 5514 5803
Office: Room 3-3-08

ORCID ID: https://orcid.org/0000-0001-8334-6821

Profile Summary

Dr Faizul bin Jaafar has joined Brain Research Institute Monash Sunway (BRIMS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia as an assistant lecturer starting in October 2019. He has received his PhD in Biochemistry from University Kebangsaan Malaysia (UKM) in 2018 and Bachelor of Science in Biochemistry (Honours) from the same university in 2011. His honours project focused particularly on ugt-29 Gene Expression in Caenorhabditis elegans Infected by Gram-Positive and Gram-Negative Pathogens. Meanwhile, his PhD thesis concentrated on the modulation of SIRT1 expression by Tocotrienol-rich Fraction (TRF) treatment to prevent replicative senescence of Human Diploid Fibroblast (HDFs). His academic qualifications are mainly in biochemistry, molecular biology and microbial genomics. During his PhD research, he was invited by Faculty of Pharmaceutical Science, Tokyo University of Science, Japan to study in longevity gene’s promoter activity in human fibroblast skin cells (Gene Regulation) from October 2014 until February 2015.

During his nine years as a researcher, he has published several papers in high-indexed journals related to medical science, genes, nutrition, biochemistry and medicine. Furthermore, he actively collaborated with fellow researchers from renown universities in Malaysia, namely Universiti Malaya (UM) and Universiti Kebangsaan Malaysia (UKM). He possesses advanced research skills in the field of genomics, transcriptomics, proteomics and metabolomics. He was also an assistant lecturer in Biochemistry and Genetics at Faculty of Medicine, Lincoln University College, Malaysia for two years.

Academic Qualifications

  • Doctor of Philosophy (Biochemistry), University Kebangsaan Malaysia (UKM) (2018)
  • Bachelor of Science (Biochemistry) (Hons), University Kebangsaan Malaysia (UKM) (2011)

Work Experiences

  • October 2019 – present. Assistant Lecturer, Brain Research Institute (BRIMS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia,  Malaysia.
  • August 2019 – September 2019. Research Assistant, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Malaysia.
  • September 2018 – July 2019. Research Assistant, Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.
  • April 2018 – August 2018. Graduate Research Assistant, Department of Biochemistry, Faculty of Medicine, University Kebangsaan Malaysia (UKM), Malaysia.­­
  • September 2017 – March 2018. Assistant Registrar, Faculty of Medicine, Lincoln University College,  Malaysia.
  • April 2016 – March 2018. Assistant Lecturer, Faculty of Medicine, Lincoln University College,  Malaysia.
  • October 2011 – February 2012. Research Assistant, Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.

Research

Publications

Jaafar, F., Durani, L. W., & Makpol, S. (2019). Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. Molecular biology reports, 1-11.

Tan, C. M., Najib, N. A. M., Suhaimi, N. F., Halid, N. A., Cho, V. V., Abdullah, S. I., Jaafar, F, … Makpol, S. (2019). Modulation of Ki67 and myogenic regulatory factor expression by tocotrienol-rich fraction ameliorates myogenic program of senescent human myoblasts. Archives of Medical Science, 15(1).

Tan, J.-K., Jaafar, F., & Makpol, S. (2018). Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol. BMC complementary and alternative medicine, 18(1), 314.

Jaafar, F., Abdullah, A., & Makpol, S. (2018). Cellular uptake and bioavailability of tocotrienol-rich fraction in SIRT1-inhibited human diploid fibroblasts. Scientific reports, 8(1), 10471.

Razak, A. M., Khor, S. C., Jaafar, F., Karim, N. A., & Makpol, S. (2018). Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation. Genes & nutrition, 13(1), 31.

Zainuddin, A., Chua, K.-H., Tan, J.-K., Jaafar, F., & Makpol, S. (2017). γ-Tocotrienol prevents cell cycle arrest in aged human fibroblast cells through p16 INK4a pathway. Journal of physiology and biochemistry, 73(1), 59-65.

Durani, L. W., Jaafar, F., Tan, J. K., Tajul Arifin, K., Mohd Yusof, Y. A., & Wan Ngah, W. Z. (2015). Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. Clin Ter, 166(6), e365-73.

Ahmad, T. A. F. T., Jaafar, F., Jubri, Z., Rahim, K. A., Rajab, N. F., & Makpol, S. (2014). Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis. BMC complementary and alternative medicine, 14(1), 108.

Research Grants

No content

Oral Presentations

Jaafar, Faizul, Abdul Sani, Nur Fathiah, Mad Nordin, Mariam Firdaus, Abd Ghafar, Norzana, Mohd Yusof, Yasmin Anum, Makpol, Suzana. Modulation of Human Myoblast Cells Viability and Cellular Senescence by Ginger Extract. International Conference of Ageing, Penang (2019)

Jaafar, Faizul, Abdul Sani, Nur Fathiah, Mad Nordin, Mariam Firdaus, Abd Ghafar, Norzana, Mohd Yusof, Yasmin Anum, Makpol, Suzana. Ginger Extract Improves Cell Viability and Prevents Cellular Ageing of Human Myoblasts in Culture. Regional Conference on Non-Communicable Diseases, Putrajaya (2018)

Jaafar, F., Mohd Yusof, Y. A., Wan Ngah, W. Z., Uchiumi, F., Makpol, S. Tocotrienol-Rich Fraction Modulates the Expression of SIRT1 and Genes Involved in the Regulation of Cell Cycle and Apoptosis. International Conference of Antioxidant and Degenerative Diseases, Kuala Lumpur. (2015)

Poster Presentations

Jaafar, Faizul, Hakimi, Nur Haleeda, Zakaria, Siti Nor Asyikin, Abd Rashid, Ahmad Fais, Mohd Ihsan, Nurhazirah, Abd Sani, Nur Fathiah, Tan, Jen-Kit, Makpol, Suzana. Evaluating the Safety and Bioavailability of Tocotrienol-rich Fraction Formulated into Palm Kernel Olein and Palm Oil Carrier in Rats. International Conference of Antioxidant and Degenerative Diseases, Kuala Lumpur. (2018)

Jaafar, F., Abdullah, A., Uchiumi, F., Makpol, S. Tocotrienol-Rich Fraction Activates SIRT1 Gene Promoter of Human Diploid Fibroblast. The 5th Palm International Nutra-Cosmeceutical Conference (PINC), Kuala Lumpur (2017)

Jaafar, F., Mohd Yusof, Y. A., Wan Ngah, W. Z., Makpol, S. Cellular Bioavailability of Tocotrienol-rich Fraction in Human Diploid Fibroblasts and its Relationship with SIRT1 Regulation. The 4th Palm International Nutra-Cosmeceutical Conference (PINC), Kuala Lumpur (2015)

Jaafar, F., Makpol, S. SIRT1 Deregulation and Tocotrienol-rich Fraction (TRF) Modulate Cell Cycle Progression and Apoptosis. The 39th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Sepang, Selangor. (2014)

Jaafar, F., Mohd Yusof, Y. A., Wan Ngah, W. Z., Makpol, S. Tocotrienol-rich Fraction (TRF) Modulated the Expression of Genes involved in the Regulation of SIRT1 in Preventing Cellular Senescence of Human Diploid Fibroblasts. The 3rd Palm International Nutra-Cosmeceutical Conference (PINC), Petaling Jaya, Selangor. (2013)

Jaafar, F., Makpol, S. Tocotrienol-rich Fraction (TRF) Modulated the Expression of SIRT1, SIRT1 Regulator and Genes involved in Cell Cycle regulation in the Prevention of Cellular Senescence. The 1st National Conference for Cancer Research in conjunction with 5th Regional Conference on Molecular Medicine (RCMM), The Royale Chulan, Kuala Lumpur. (2013)

Jaafar, F., Makpol, S. Tocotrienol-rich Fraction Modulated the Expression of Genes Involved in The Regulation of SIRT1 Expression in Preventing Cellular Senescence. 1st International Conference on Advances in Medical Science (ICAMs). (2013)

3 Minutes Thesis Presentations

Jaafar, F. Palm Oil Vitamin E, “Tocotrienol”, Better Nutrition. 3 Minutes thesis competition, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia (2017)

Jaafar, F. Palm Oil Vitamin E (Tocotrienol, TRF) targeting SIRTUIN 1 (SIRT1) – Elixir to healthy aging. 3 Minutes thesis competition, Universiti Kebangsaan Malaysia, Malaysia (2015)

Awards

Best Oral Presenter at International Conference of Antioxidant and Degenerative Diseases,  2015.

Best Poster Presenter at The 39th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology (MSBMB), 2014.

Dean Award, Faculty of Science and Technology, UKM, 2011

Other Achievements

Awarded with Mobility Student Exchange Grant, Universiti Kebangsaan Malaysia, 2014.

Invited PhD student to study Gene Regulation (Pharmaceutical Science) at Tokyo University of Science (2014)