Dr Muhamad Noor Alfarizal Bin Kamarudin

Lecturer

Jeffrey Cheah School of Medicine & Health Sciences

Email: MuhamadNoor.Alfarizal@monash.edu
Tel: +603 5515 9644
Fax: +603 5514 6341
Office: Room 3-3-03

ORCID ID: https://orcid.org/0000-0003-2505-1018

Profile Summary

Dr Alfarizal Kamarudin is a lecturer at Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia. He specializes in cancer biology, particularly in human glioma and glioblastoma research. He also develops collaborative research in solid malignant tumors, neuroimmunology, neuroprotection, and natural products. He aims to identify and develop newer diagnostic and therapeutic approach in human gliomas by targeting the drug resistance and cell motility mechanisms.

He completed his Bachelor's Degree (Biochemistry, Hons) from the University of Malaya (UM). He pursued his Master's studies, which he successfully converted into a doctorate program (UM, 2012). He previously obtained a postdoctoral researcher position under a three-way collaboration between UM, Taibah University of Medina, and Lincoln College University on Glioblastoma project in October 2017.

His PhD thesis focused on modulating molecular signaling in neuroinflammation with particular attention to cytokines and chemokines. He identified a potentially novel role of CCL21/exodus in neuronal differentiation key regulator of microglia activation. Through this, he developed an immense interest and in-depth knowledge on the modulation of neuroinflammation, particularly innate immunity in neurons and glia in neuroprotection, neuritogenesis, and anti-inflammatory.

He has also won several awards his such as Best Thesis Award University Malaya & Amersham Biosciences Prize by Malaysia Society of Biochemistry and Molecular Biology (MSBMB), 1st Prize Oral Presenter at InPRAS Conference UM 2014, 1st Prize Poster Presenter at World Congress on Healthy Ageing, Best Poster Presentation, 39th Annual Malaysian Society for Biochemistry and Molecular Biology Conference, and Silver Medal Winner for Poster Presentation (Biochemistry & Physiology), at Biological Sciences Graduate Congress, the National University of Singapore, 2014.

Academic Qualifications

  • Doctor of Philosophy (Biochemistry), University of Malaya
  • Bachelor of Science (Biochemistry, University of Malaya – Best Thesis Award, University of Malaya
  • Associate Diploma (Instrument Studio Teaching), International Music of Exam Board, Australia.

Research Experience & Employment

  • January 2022 – present: Lecturer, Jeffrey Cheah School of Medicine, Monash University Malaysia.
  • Oct 2017: Research Fellow, Brain Research Institute Monash Sunway (BRIMS), Jeffrey Cheah School of Medicine, Monash University Malaysia.
  • 2016 – 2017: Post-doctorate, Lincoln University College

Professional Membership

  • Malaysia Society of Neuroscience
  • Malaysian Society for Biochemistry and Molecular Biology

Thesis

  • PhD Thesis (2012 – 2016)
    Title of Thesis: (R)-(+)-α-lipoc acid and mesuagenin c-induced regulation of NF-κB, cytokines and chemokines via PI3K-AKT/GSK-3β and ERK1/2 in in vitro neuronal models.
    Short  description:  The investigation  on  the protective  and  neuritogenic effects  of  the natural products in neuronal models (neurons, microglia and neuron-glia) in regulating innate immunity by PI3K-AKT/GSK-3β  and  ERK1/2. The work discovered the possible novel role CCL21 in neurite outgrowth and differentiation.
  • Master (2011– 2012, Converted to Ph.D)
    Title  of Thesis:  Mesuagenin  c mediated  neuroprotective  and neuritogenic  in  neuronal models through cytokines and chemokine via regulation of NF-κB.
  • Bachelor (2010)
    Title of Thesis: Structural-Activity Analysis of Indolic Gallic  Acid Hydrazones Derivatives on Human  Breast Adenocarcinoma  Cell  Line (MCF-7)  and  Human Colon  Adenocarcinoma  Cell Line (HCT-119)
    This thesis has been conferred with Best Thesis Award & Amersham Biosciences Award by the Malaysia Society of Biochemistry and Molecular Biology (MSBMB).

Journal Papers in Preparation

  • Kamarudin,  M.  N.  A. & Parhar, I. S. (2018).  The emerging therapeutic potential of anti- psychotics drugs in the management  of human gliomas. (Review  Article, in preparation for Neuro-oncology).
  • Kamarudin, M. N. A., Parhar, I. S., & Sarker, M. M. R. (2018). Is metformin effective for the treatment of colorectal cancer? A review on its molecular mechanism, pre-clinical and clinical aspects. (Oncotarget).
  • Sheikh, B. Y., Kamarudin, M. N.  A., Parhar, I. S., Sarker, M. M. R., & Mohan, G. D.M. (2016). Oleic acid induces growth inhibition and ROS-mediated mitochondrial-mediated apoptosis in  Ca Ski cells. (Prostaglandins, Leukotrienes and Essential Fatty Acids).

Personal Interest

Orchestra conducting - Principal Conductor for Alam Shah Wind Orchestra with various National and International Awards.

Research Interests

Dr Alfa’s primary research aspiration is to develop novel therapeutic targets in human gliomas management that will tackle tumor cell motility, chemoresistant, and tumor recurrence, ultimately improving the prognosis among patients with different tumor status backgrounds. His cardinal focus is on targeting multimodal mechanistic pathways using molecules such as natural products, neuropeptides, and noncoding RNAs. Additionally, his research team focuses on the alternative neuroendocrine system since gender disparity is seen in human gliomas. He envisions human gliomas management's bright future through neo-adjuvants' potentiality in improving current established therapy that enhances patients' prognoses while being cost effective with marginal side effects would lead to more affordable treatment gliomas.

He has been involved in obtaining various research grants such as FRGS grant 2019, BRIMS-JCSMHS collaboration grants (2020), High Impact Research (HIR) UM, Fundamental Research Grant Scheme (MoHE – Best FRGS Project Award 2014), and University Malaya Research Grant (UMRG). He is also an active reviewer for several journals such as the Journal of Experimental & Clinical Cancer Research, Scientific Reports, Cellular and Molecular Life Sciences, Biomedicine & Pharmacotherapy, Frontiers in Pharmacology, Frontiers in Aging Neuroscience, Oncotarget and Therapy, Molecular and Cellular Biochemistry, Journal of Ethnopharmacology, Cancer Management and Research, and Journal of Functional Food.

Research Expertise

  • Neuro-oncology & Cancer biology (Drug resistance and Cell Motility)
  • Molecular Biology & Diseases Mechanism
  • Nutraceuticals
  • Molecular signal transduction – Protein Signaling
  • Neuroimmunology

Current Research Projects

  • Kisspeptin/GPR54 as an adjuvant therapeutic target in human glioblastoma.
  • GPR54 activation of promotes Temozolomide chemosensitization in human glioblastoma cells
  • Lentinan as chemosensitizer agent of temozolomide in human glioblastoma.
  • Chrysin chemosensitizes temozolomide in human glioblastoma.
  • Lentinan and chrysin combination as apoptosis and ferroptosis inducer in human glioblastoma.
  • Human GBM secreted factors as diagnostic and therapeutic approach in human gliomas.
  • Role of Long noncoding RNAs in human glioblastoma migration and invasion.
  • Role of Long noncoding RNAs in towards temozolomide resistance in glioblastoma.
  • Glioblastoma secreted factors induce neuronal dysfunction in differentiated cholinergic SH-SY5Y cells.
  • Developing a 3D spheroid-based preclinical model of human glioblastoma to evaluate the anti-cancer effects of Temozolomide.
  • Elucidating the Mechanisms of Kisspeptin in Regulating Glioblastoma Cell Motility
  • Chemosensitisation effects and mechanisms of action of curcumin against temozolomide in High Grade Gliomas.
  • Discovery of biomarkers of following supplementation of Tocotrienols in two human glioblastoma cells using quantitative proteomics profiling strategies.
  • An organoid model of human breast cancer:  Unravelling the effects of anticancer drugs and vitamin E

Monash Teaching Commitment

  • MED 1100/1200 - PBL Year 1
  • MED 2100 & MED 2200 - Student project cases
  • MED5101 - Applied Studies in Medical Research and Professional Practice/Scholarly Intensive Placement (SIP)

Publications

Peer reviewed Journal Papers

Phon, B. W. S., Kamarudin, M. N. A, Bhuvanendran, S., & Radhakrishnan, A. K. (2022). Transitioning pre-clinical glioblastoma models to clinical settings with biomarkers identified in 3D cell-based models: A systematic scoping review. Biomedicine & Pharmacotherapy, 145, 112396. (Top10%, Q1, IF: 6.529) https://doi.org/10.1016/j.biopha.2021.112396

Chelliah, S. S., Bhuvanendran, S., Magalingam, K. B., Kamarudin, M. N. A., & Radhakrishnan, A. K. (2022). Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson’s disease: A systematic review of proteomics studies. Ageing Research Reviews, 73, 101514. (Top1%, Q1, IF: 10.895) https://doi.org/10.1016/j.arr.2021.101514

Osman, Dina; Wee Siang Phon, Brandon; Kamarudin, Muhamad; Ponnampalam, Stephen; Radhakrishnan, Ammu; Bhuvanendran Pillai, B Saatheeyavaane (2022). Biomarkers regulated by lipid-soluble vitamins in glioblastoma: A systematic descriptive review. (Nutrition Reviews Submitted, Top10%, IF: 7.110)

Phon, B. W. S., Chelliah, S. S., Osman, D., Bhuvanendran, S., Radhakrishnan, A. K. & Kamarudin, M. N. A, (2022). A Deep Dive into the Preclinical Export of ABC Transporters: A Systematic Scoping Review. (Molecular Cancer, Submitted, Top5%, IF:27.401)

Tan, J. Y., Wijesinghe. I. V. S., Kamarudin, M. N. A., Parhar, I. (2021) Paediatric gliomas: BRAF and Histone H3 as biomarkers, therapy and perspective of liquid biopsies. Cancers, Special Issue of Pediatric Brain Tumors (Q1, IF= 6.639). https://doi.org/10.3390/cancers13040607

Wong, S. C., Kamarudin, M. N. A., Naidu, R. (2021) Anticancer Mechanism of Curcumin on Human Glioblastoma. Nutrients, Special Issue of Dietary Curcumin and Health Effects (Q1, IF= 5.719). https://doi.org/10.3390/nu13030950

Chelliah, S. S., Kamarudin, M. N. A., Paul, E. A. L., Parhar, I. (2021) High-grade gliomas: Challenges and current views of drug development and therapy. Molecules, Special Issue of Anticancer Drug Discovery and Development (Q2, IF= 4.412). https://doi.org/10.3390/molecules26041169

Mohamad, N. A., Tan A. S., M. Suhaimi, Kamarudin, M. N. A., Mohd Fadzli M. D., Mohd Azlan, N. 4, Noel F. T, Abdul Kadir, H., Awang, K. (2021). Synthesis of Indolostilbenes via FeCl3-Promoted Oxidative Cyclization and Their Protective Properties Against H2O2 in NG108-15 cells. Journal of Physical Sciences, 32(1), 69–89 (Q3, IF= 1.01). https://doi.org/10.21315/jps2021.32.1.6

Kamarudin, M. N. A., Sarker, M. M. R., Zhou, J. R., & Parhar, I. (2019). Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects. Journal of Experimental & Clinical Cancer Research, 38(1), 491.  (Q1, IF: 5.646) https://doi.org/10.1186/s13046-019-1495-2

Kamarudin, M. N. A, & Parhar, I. (2019). Emerging therapeutic potential of anti-psychotic drugs in the management of human glioma: A comprehensive review. Oncotarget, 10(39), 3952. (Q1, IF: 3.331 ) https://doi.org/10.18632/oncotarget.26994

Chan, C. K., Tan, L. T. H., Andy, S. N., Kamarudin, M. N. A., Goh, B. H., & Kadir, H. A. (2017). Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells. Frontiers in Pharmacology, 8, 397.

Sheikh, B. Y., Sarker, M. M. R., Kamarudin, M. N. A., & Mohan, G. (2017). Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. Biomedicine & Pharmacotherapy, 96, 834-846.

Kamarudin, M. N. A., Sarker, M. M. R., Kadir, H. A., & Ming, L. C. (2017). Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review. Journal of Ethnopharmacology.

Sheikh, B. Y., Sarker, M. M. R., Kamarudin, M. N. A., & Ismail, A. (2017). Prophetic medicine as potential functional food elements in the intervention of cancer: A review. Biomedicine & Pharmacotherapy, 95, 614-648.

Supriady, H., Kamarudin, M. N. A., Chan, C. K., Goh, B. H., & Kadir, H. A. (2015). SMEAF attenuates the production of pro-inflammatory mediators through the inactivation of Akt-dependent NF-κB, p38 and ERK1/2 pathways in LPS-stimulated BV-2 microglial cells. Journal of Functional Foods, 17, 434-448.

Syed Hussein, S. S., Kamarudin, M. N. A., & Abdul Kadir, H. (2015). (+)-Catechin Attenuates NF-κB Activation Through Regulation of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells. The American Journal of Chinese Medicine, 43(05), 927-952

Lo, J. Y., Kamarudin, M. N. A., Hamdi, O. A. A., Awang, K., & Kadir, H. A. (2015). Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food & function, 6(11), 3550-3559.

Hamdi, O. A. A., Ye, L. J., Kamarudin, M. N. A., Hazni, H., Paydar, M., Looi, C. Y., ... & Awang, K. (2015). Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes. Records of Natural Products, 9(3), 349.

Moghadamtousi, S. Z., Kamarudin, M. N. A., Chan, C. K., Goh, B. H., & Kadir, H. A. (2014). Phytochemistry and biology of Loranthus parasiticus Merr, a commonly used herbal medicine. The American journal of Chinese medicine, 42(01), 23-35.

Kamarudin, M. N. A., Raflee, N. A. M., Hussein, S. S. S., Lo, J. Y., Supriady, H., & Kadir, H. A. (2014). (R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines. Drug design, development and therapy, 8, 1765.

Goh, B. H., Chan, C. K., Kamarudin, M. N. A., & Kadir, H. A. (2014). Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells. Journal of ethnopharmacology, 153(2), 375-385.

Chan, G., Kamarudin, M. N. A., Wong, D. Z. H., Ismail, N. H., Abdul Latif, F., Hasan, A., ... & Abdul Kadir, H. (2012). Mitigation of H2O2-induced mitochondrial-mediated apoptosis in NG108-15 cells by novel mesuagenin C from Mesua kunstleri (King) kosterm. Evidence-Based Complementary and Alternative Medicine, 2012.

Chan, C. K., Goh, B. H., Kamarudin, M. N. A., & Kadir, H. A. (2012). Aqueous fraction of Nephelium ramboutan-ake rind induces mitochondrial-mediated apoptosis in HT-29 human colorectal adenocarcinoma cells. Molecules, 17(6), 6633-6657.

Proceeding/Conference Abstracts

Mesuagenin C attenuated LPS-stimulated BV-2 and NG108-15 cells by modulating  NF-κB,  CCL21 and  cytokines through PI3K-  Akt/GSK-3β. FEBS  EMBO 2014,  Palais des  Congrès  in Paris,  France,  August 30-September  4,  2014. Special  Issue: FEBS EMBO 2014 Conference, FEBS Journal, 281(s1), 1(823).

Protective effects of (R)-(+)-α-Lipoic Acid against MPP+-stimulated microglia  cells  and toxicity in  dopaminergic  SH-SY5Y cells  through  PI3K-Akt/GSK- 3β pathway. FEBS EMBO 2014, Palais des Congrès in Paris, France, August 30-September 4, 2014. Special Issue: FEBS EMBO 2014 Conference, FEBS Journal, 281(s1), 1(823).

Catechin supressed  LPS-induced  neuroinflammation  in BV-2,  C6 and NG108-15 cells by modulating CCL21 through PI3K-Akt. Journal of the Neurological Sciences, 333, e337.   XXI World Congress of Neurology held at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013.

α-Lipoic  acid  protects against  LPS-induced  BV-2 activation  and MPTP- induced toxicity in SH-SY5Y neuronal cells. Journal of the Neurological Sciences, 333, e338. XXI World Congress of Neurology held at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013.

Mesuagenin C mitigated  LPS-induced  neuroinflammation in BV-2 and  NG108-15 cells  through  pMTOR-PI3K-Akt  and CCL21  downregulation.  Journal of the  Neurological  Sciences, 333,  e349.  XXI World  Congress  of Neurology  held  at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013. 2013.

Conference Presentation

Oral paper presentation

Chrysin and lentinan chemosensitize temozolomide in GBM. MSPP 34th Scientific Meeting 2021.

Mesuagenin c suppresses microglia inflammation and improves neuronal   survival   by modulating   NF-Κb,   cytokines and   chemokines   through PI3K- Akt/GSK-3β. International Post-Graduate Seminar University of Malaya 2014.

Neuroprotective and  neuritogenic  molecular mechanisms  of novel   mesuagenin C   from   Mesua kunstleri   (King)   Kosterm in      NG108-15   cells. Symposium  on Natural  Products  and Medicinal  Chemistry  (NPMC), 17th  Malaysian Chemical Congress (17MCC),  October  15- October  17,  2012, Putra  World  Trade Centre, Kuala Lumpur, Malaysia.

Neuroprotective and  neuritogenic  molecular mechanisms  of mesuagenin  C from  Mesua   kunstleri through  CCL21  regulation in  NG108-15   cells. International Conference on Molecular Biology and Biochemistry, WASET. May 28 – Jun 1, Chiba, Tokyo, Japan.

Poster  presentation:

Neuroprotection and neuritogenesis effects of Mesuagenin C from Mesua kunstleri in NG108-15 cells. The 1st World Congress on Healthy Ageing 2012, 19th to 22nd March 2012 at Kuala Lumpur Convention Centre.

α-Lipoic  acid  mitigated H2O2-induced mitochondrial-mediated apoptosis in NG108-15 cells through PI3K-AKT pathway.  24th Intervarsity Biochemistry Seminar, 11 May 2013 to 11 May 2013, Taylor's University College & Malaysian Society of Biochemistry and Molecular Biology (MSBMB).

Swietenia macrophylla  ethyl  acetate fraction  suppressed  LPS- induced neuroinflammation  in  BV-2 cells  through  PI3K/Akt and  MAPK  pathways. 39th Annual  Conference  of The  Malaysian  Society for  Biochemistry  & Molecular  Biology, 25th-26th June 2014, Sama-Sama Hotel, KLIA, Sepang, Malaysia.

Mesuagenin C attenuated LPS-stimulated BV-2 and NG108-15 cells by modulating  NF-κB,  CCL21 and  cytokines through PI3K-  Akt/GSK-3β. FEBS  EMBO 2014,  Palais des  Congrès  in Paris,  France,  August 30-September  4,  2014. Special  Issue: FEBS EMBO 2014 Conference, FEBS Journal, 281(s1), 1(823).

Protective effects of (R)-(+)-α-Lipoic Acid against MPP+-stimulated microglia  cells  and toxicity in  dopaminergic  SH-SY5Y cells  through  PI3K-Akt/GSK- 3β pathway. FEBS EMBO 2014, Palais des Congrès in Paris, France, August 30-September 4, 2014. Special Issue: FEBS EMBO 2014 Conference, FEBS Journal, 281(s1), 1(823).

Catechin supressed  LPS-induced  neuroinflammation  in BV-2,  C6 and NG108-15 cells by modulating CCL21 through PI3K-Akt. Journal of the Neurological Sciences, 333, e337.   XXI World Congress of Neurology held at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013.

α-Lipoic  acid  protects against  LPS-induced  BV-2 activation  and MPTP- induced toxicity in SH-SY5Y neuronal cells. Journal of the Neurological Sciences, 333, e338. XXI World Congress of Neurology held at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013.

Mesuagenin C mitigated  LPS-induced  neuroinflammation in BV-2 and  NG108-15 cells  through  pMTOR-PI3K-Akt  and CCL21  downregulation.  Journal of the  Neurological  Sciences, 333,  e349.  XXI World  Congress  of Neurology  held  at Reed Messe Wien GmbH Congress Center, Vienna, Austria, September 21-26, 2013. 2013.

Curcumenol from curcuma zedoaria suppresses neuroinflammation induced by LPS in BV-2 neuronal cell model. 18th Biological Sciences Graduate Congress, 06 Jan 2014 to 08 Jan 2014, Faculty of Science, University of Malaya.

Catechin  from  Loranthus parasiticus  (L.)  Merr attenuated  LPS- induced neuroinflammation in BV-2 cells. 38th The Malaysian Society for Biochemistry & Molecular Biology Annual Conference, 28 Aug 2013 to 29 Aug 2013, The Malaysian Society for Biochemistry & Molecular Biology (MSBMB), (National

(+)-Catechin Attenuates  NF-κB  Activation Through Regulation  of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells. 19th Biological  Sciences Graduate  Congress,  12 Dec  2014  to 14  Dec  2014, Department  of Biological Sciences in National University of Singapore (International).

Research Grants

JCSMHS Early Career Researcher (ECR) Grants 2022 - Investigation of proteomic changes as a strategy to characterize kisspeptin-mediated glioblastoma cell motility mechanisms /RM10, 0000 (Principal Investigator).
Status: Ongoing

JCSMHS Strategic Grant 2022 - Synergism and Anticancer Mechanism of Diarylpentanoid MS17 and Chrysin Combination in Human Chemoresistant Glioblastoma Cells./RM54, 000 (Co-investigator).
Status: Ongoing

Yayasan Penyelidikan Otak, Minda dan Neurosains Malaysia (YPOMN) 2021 - Identification of spexin receptors & their functionality in human glioblastoma with different Temozolomide sensitivity/RM5, 0000 (Co-Investigator).
Status: Ongoing
Major Finding/Output: Identification of spexin receptor and spexin neuropeptide in GBM motility.

JCSMHS Seed Grants 2021 - Investigation of chrysin and lentinan as a potential nutraceutical-based regulator of ferroptosis in correlation with their proteomic changes in p53 wildtype and mutant glioblastoma/RM20, 0000 (Co-investigator).
Status: Ongoing
Major Finding/Output: Oral presentation at 34th MSPP, new mechanistic mechanism of reversing chemoresistance by chryin and lentinan through ferroptosis in GBM.

JCSMHS Strategic Grant 2021 - Modulation of host immune system by supplementation of palm vitamin E and carotenoids: elucidating the mechanisms of action using a mouse model of COVID-19 vaccination/RM60, 000 (Co-investigator).
Status: Ongoing

JCSMHS Strategic Grant 2021 - Development of a whole genome yeast two hybrid screening based drug discovery platform for potential novel host protein based therapeutics as an antiviral strategy using Enterovirus D68 as a model/RM100, 000 (Co-investigator).
Status: Ongoing

FRGS (2019-2021) – Estrogen receptor is indispensable for the suppression of glioblastoma cell migration and invasion by Kisspeptin/RM159, 200 (Co-investigator).
Status: Ongoing
Major Finding/Output: Identification of GPR54receptor and kisspeptin neuropeptide in GBM motility and as TMZ chemosensitizer, contradictory to other findings in different cancer.

BRIMS/JCSMHS Collaboration Grant (2021) – Developing a 3D spheroid-based preclinical model of human glioblastoma to evaluate the anti-cancer effects of Temozolomide/RM20, 000 (Co-investigator).
Status: Completed.
Major Finding/Output: Publication in Top10%, Q1.

BRIMS/JCSMHS Collaboration Grant (2020) – Chemosensitisation effects and mechanisms of action of curcumin against temozolomide in High Grade Gliomas/RM20, 000 (Co-investigator).
Status: Ongoing
Major finding/Output: Publication in Q1 and sensitization of Temozolomide by curcumin in human GBM.

BRIMS/JCSMHS Collaboration Grant (2020) – Discovery of biomarkers of following supplementation of Tocotrienols in two human glioblastoma cells using quantitative proteomics profiling strategies /RM20, 000 (Co-investigator).
Status: Ongoing.
Major Finding/Output: Submission of publication in Top10%, Q1 and discovery of tocotrienol isoforms activity in human GBM.

IPPP – PostGraduate Research Fund (UM, 2012-2015). Molecular Mechanisms Of NF-κb-CCL21 Regulation By Mesuagenin C-Induced Neutritogenesis In NG108-15 Cells (Co-investigator).
Status: Completed.
Major Finding/Output: Publication in Q1.

Fundamental Research Grant Scheme (FRGS, 2014-2016): Investigation On CCL21-NF-κB Regulation By Catechin From Loranthus Parasiticus in In Vitro And In Vivo Alzheimer's Models. This is an award grant as for best FRGS Project 2014.
Status: Completed.
Major Finding/Output: Publication in Top10%, and Q1.
Responsible for the write-up of this grant, the management of the grant and project execution/ RM180, 000 (Co-investigator).

High Impact Research (HIR, 2013 – 2015) Project: Novel NF-κB - Chemokines Regulatory Mechanisms By Selected Phytochemicals on Neuronal Models/ RM240, 000 (Co-investigator).
Status: Completed.
Major Finding/Output: Publications in Q1.
Responsible for the write-up of this grant, the management of the grant and project execution.

  1. Main Supervision of GR StudentS (JCSMHS, MUM - Ongoing)
    • Ms. Ayesha Atiq (Ph.D.)
    • Ms. Isra Sati (Ph.D.)
    • Ms. Prakrithi Narayanan (Ph.D.)
    • Mr. Dexter Hoi Long Leung (Ph.D.)
    • Mr. Brandon Phon Wee Siang (Ph.D.)
    • Ms. Sylvia Liew Sue Xian (Ph.D.)
    • Ms. Chow Min Yee (Ph.D.)
  2. Co-supervision of GR students (JCSMHS, MUM – Ongoing)
    • Ms. Dina El-Rabie AbuBakar Osman (Ph.D.)
    • Ms. Shaza Mohamed Musa Mohamedahmed (Ph.D.)
    • Ms. Wong Shu Chyi (Masters)
  3. Co-Supervision of BMeds Sc Honour  (JCSMHS, MUM - Completed)
    • Dr. Lin Chen Haw (High Distinction)
    • Dr. Chung Yuang Min (High Distinction)
  4. Co-Supervision of Science Honour (BRIMS, JCSMHS, MUM - Completed)
    • Ms. Shalini Sundramurthi Chelliah (High Distinction and Best Science Honour Graduate)
  5. Supervision of SIP (5th Year), SPC (2nd Year), RSP & YSP students (JCSMHS, MUM) since 2019 - 2021
  6. Supervision and mentoring of undergraduate research projects (2011 - 2016) (University Malaya)
  7. Mentoring of Master and Ph.D students (2012 - 2016) (University Malaya)
  8. Tutor Biochemistry Practical Class (2015 & 2016) (University Malaya)

Supervision interests

My supervision interests are in the field of:

  • Neuro-oncology (Gliomas, Glioblastoma)
  • Cancer biology (Giiomas, CRC, Breast Cancer)
  • Molecular Biology & Diseases Mechanism
  • Nutraceuticals (Natural Products)
  • Molecular signal transduction – Protein Signaling
  • Neuroimmunology, Neuroprotection, Neuroinflammation

Awards

Best Thesis Award & Amersham Biosciences Prize by Malaysia Society of Biochemistry and Molecular Biology (MSBMB), Malaysia.

1st Prize Oral Presenter at InPRAS Conference UM 2014.

1st Prize Poster Presenter at World Congress on Healthy Ageing 2012

Best Poster Presentation, 39th Annual Malaysian Society for Biochemistry and Molecular Biology Conference, 2014, (INTERNATIONAL)

Silver Medal Winner for Poster Presentation (Biochemistry & Physiology), 19th Biological Sciences Graduate Congress, National University of Singapore, 2014 (International).

Silver Medal Winner for Poster Presentation (Biochemistry & Physiology), 18th Biological Sciences Graduate Congress, University of Malaya, 2014.

Poster Winner - 26th Inter Varsity Biochemistry Seminar, 26th Inter Varsity Biochemistry Seminar & Malaysian Society for Biochemistry and Molecular Biology, 2015, (NATIONAL)

Poster Winner (Two Undergraduate Students) - 24th Inter Varsity Biochemistry Seminar, 24th Inter Varsity Biochemistry Seminar,Malaysian Society for Biochemistry and Molecular Biology, 2013