Associate Professor Rakesh Naidu

Contact Details

Tel: +603 5514 6345
Fax: +603 5514 6323
Office: Room 4-4-09
Email: rakesh.naidu@monash.edu

Profile Summary

Dr Rakesh Naidu is Associate Professor in Biomedical Science at the Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia. He was a lecturer in International Medical University and Department of Molecular Medicine, Faculty of Medicine, University of Malaya prior to his appointment in Monash University. He is involved in the teaching of biochemistry, genetics and cancer. His current research focuses on molecular biology of cancer and cancer therapeutics. He has been successful in securing several internal and external research grants in the research areas of molecular oncology and cancer therapeutics. He has published peer-reviewed research papers in several international and national journals and book chapters in cancer. He has supervised and currently supervising several graduate students including PhD and Masters over the years.

Qualifications

  • Bachelor of Science (Education) (Hons), University Sains Malaysia
  • Master of Science, University of Malayia
  • Doctor of Philosophy, University of Malaya

Memberships

  • American Association for Cancer Research
  • Human Genome Organisation (HUGO)
  • Malaysian Society for Molecular Biology & Biotechnology
  • Malaysian Society for Biochemistry and Molecular Biology
  • Malaysian Society for Genetics
  • Old Frees Association (OFA)

Research & Education

Research Interests

Dr Rakesh Naidu is actively involved in cancer research. One of the research interests is to understand the molecular alterations that lead to cancer development with particular focus on breast, prostate and colon cancers. Genomics and proteomics analysis were performed on human cancer samples to determine and identify several genetics alteration that could potentially be used as biomarkers and to understand mechanisms underlying cancer development. Some of the genetic alterations noted were distinct than that reported by other investigators perhaps of different demographics and ethnic population. Currently, his research group focuses on identification and understanding the underlying molecular mechanisms of synthetic compounds and analogues derived from natural compounds as well as natural components from venoms that contribute to anti-cancer activities in human cancer cells such as cervical, prostate, colon, breast and lung. Several ‘omics’ platform technologies such as transcriptomics and proteomics are used to identify specific target mRNAs, miRNAs and proteins as well as relevant biological pathways modulated by these potential anticancer compounds. High-density microarrays, sequencing and mass spectrometry are used to achieve these outcomes which contribute to the understanding of targeted anti-cancer therapy by these compounds that may lead to future development of novel anti-cancer drugs.

Keywords: biomedical science, cancer therapeutics, molecular oncology, genomics, transcriptomics, proteomics

Monash Teaching Commitment

  • Student Project Cases
  • Problem Based Learning
  • Biochemistry

Chapters in Books

Naidu, R., Yip, C.H., and Nur Aishah, M.T. (2006). Human Telomerase Reverse Transcriptase Gene Amplification in Breast Tumors. In: Breast Cancer in Malaysia: Issues and Educational Implications. (Edited by H Zailina, Zalilah M.S. and Mazanah M). Pp. 36-41. Institute for Social Science Studies, Universiti Putra Malaysia. Ampang Press Sdn Bhd. Kuala Lumpur.

Naidu, R. (2004). Immunohistochemistry of C-MYC In Breast Carcinoma. In: Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas: Molecular Genetics, Lung and Breast Carcinomas. (Edited by M.A. Hayat). Vol. 1 pp. 395-408. Elsevier Academic Press. San Diego.

Selected Peer-Reviewed Journals

Zainal Abidin, S.A., Rajadurai, P., Chowdhury, M.E.H., Othman, I., & Naidu, R. (2018). Cytotoxic, anti-proliferative and apoptosis activity of L-amino acid oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) venom on human colon cancer cells. Molecules. 23(6): 1388-1404

Zainal Abidin, S.A., Rajadurai, P., Chowdhury, M.E.H., Ahmad Rusmili, M.R., Othman, I., & Naidu, R. (2018). Cytotoxic, anti-proliferative and apoptosis inducing activity of L-amino acid oxidase (LAAO) from Malaysian Calloselasma rhodostoma on human colon cancer cells. Basic & Clinical Pharmacology & Toxicology. 123(5):577-588.

Yap, C.G., Naidu, R, Jin, K.D., Sirasanagandla, S.R., & Pamidi, N. (2018). Pleiotropic effects of metformin in managing type 2 diabetes and metabolic syndrome: evidences from experimental mouse model. Biomedical Research. 29(17): 3323-3335.

Citalingam, K., Abas, F., Lajis, N.H., Othman, I., & Naidu, R. (2018). Identification of commonly regulated protein targets and molecular pathways in PC-3 and DU145 androgen-independent human prostate cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one. Asian Pacific Journal of Tropical Biomedicine. 8(9): 436-445.

Citalingam, K., Abas, F., Lajis, N.H., Othman, I., & Naidu, R. (2018). Identification of commonly regulated genes and biological pathways as potential targets in PC-3 and DU145 androgen-independent human prostate cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one. International Journal of Clinical Experimntal Medicine. 11(7): 7004-7017

Paulraj, F, Abas, F., Lajis, N.H., Othman, I., Hassan, S.S., & Naidu, R. (2018). Identification of commonly regulated genes in HPV18- and HPV16-infected cervical cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one. Asian Pacific Journal of Tropical Biomedicine. 8(1): 44-51

Chew, J.H., Paulra,j F., Abas, F., Lajis, N.H., Othman, I., & Naidu, R. (2017). Curcumin Analogue 1,5-Bis (4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadiene-3-One Alters Protein Expression Patterns In HPV16-Infected Cervical Cancer Cells. International Journal of Pharma and Bio Sciences. 8(4): (B) 391-403

Zainal Abidin, S.A., Rajadurai, P., Chowdhury, M.E.H., Ahmad Rusmili, M.R., Othman, I., & Naidu, R. (2016). Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus Venom Using Shotgun-Proteomics. Toxins 8(10): 299-303.

Paulraj, F, Abas, F., Lajis, N.H., Othman, I., Hassan, S.S., & Naidu, R. (2015). The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells. Molecules 20(7):11830-11860.

Aghakhanian, F., Yunus, Y., Naidu, R., Jinam, T., Manica, A., Hoh, B.P., & Phipps, M.E. (2015) Unravelling the Genetic History of Negritos and Indigenous populations of South East Asia. Genome Biology and Evolution. 7(5):1206-1215.

Citalingam, K., Abas, F., Lajis, N.H., Othman, I., & Naidu, R. (2015) Anti-Proliferative Effect and Induction of Apoptosis in Androgen-Independent Human Prostate Cancer Cells by 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one. Molecules 20(2):3406-3430.

Phipps, M.E., Kevin, K.L., Naidu, R., Mohamad N W., Hoh, B.P., Quek, KF., Ahmad, B., Harnida, S.M., Zain, A.Z., & Kadir, K.A. (2015) Cardio-metabolic health risks in indigenous populations of Southeast Asia and the influence of urbanization. BMC Public Health 15:47

Yadav A, Naidu R. (2015). Clinical manifestation and sensitization of allergic children from Malaysia. Asia Pacific Allergy. 5:78-83.

Kok Y.Y., Chu, W.L., Phang, S.M., Mariam, S.M., Naidu, R., Lai, P.J., Ling, S.N., Mak, J.W., Lim, P.K.C., Balraj, P., Khoo, ASB. (2014). Inhibitory activities of microalgal extracts against the expression of Epstein-Barr virus (EBV) antigens in lymphoblastoid cells. Archives of Biological Sciences. 66 (3), 1009-1024.

Naidu, R., Nee, L.V., Mak, J.W., Moissinac, K., Jamal, ARA., Rose, I.M., Alif Gul, YG., Lim, P.K.C., & San GTJ. (2014). Immunohistochemical Analysis of STAT3, pSTAT3, MMP-7 and VEGF Expression in Colorectal Adenocarcinoma. Journal of Cancer Therapy 5: 1175-1185

Ching, C.H., Mun, K.S., & Naidu, R. (2013) SNP Array Technology: An Array of Hope in Breast Cancer Research. Malaysian Journal of Pathology. 35: 33-43

Yadav, A., & Naidu, R. (2013). Cord IgE and ECP levels of Malay Neonates. Allergologia et Immunopathologia (Madr). 41: 364-368.

Research Grants

Principal Investigator

Completed

Genetic Analysis of a Selected Gene in Breast Cancer. (Fundamental Research Grant, University of Malaya)
Period: 2004-2006

Integrated Analysis of Genetic Aberrations and Identification of Target Genes in Breast Carcinomas. (Monash University Malaysia)
(E-ScienceFund - Ministry of Science, Technology and Innovation, Malaysia)
Period: 2007-2010

Mechanisms of Action of Selected Bioactive Synthetic Diarylpentanoids on Cell Growth Regulation of Human Colorectal Cancer Cells. (Monash University Malaysia)
Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia Period: 2011-2013

Identification of Distinct Signaling Pathways and Molecular Targes in Androgen-responsive and nonresponsive Human Prostate Cancer Cells Treated by Selected Synthetic Diarylpentanoids. (Monash University Malaysia)
Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia
Period: 2013-2015

Ongoing

Expression Profile and Identification of Specific microRNAs, Protein Targets and Regulated Pathways in Human Prostate Cancer Cells Treated by a Selected Synthetic Diarylpentanoid.
(Monash University Malaysia) Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia
Period: 2016-2019

Co-Investigator

Completed

Molecular Studies on Diseases Biomarkers and Pathogenesis of Cancer: Colorectal Carcinoma as a Model. (International Medical University)    
(Top Down National Biotechnology Directorate – Medical Biotechnology Cooperative Centre).
Period: 2002-2004

Mechanism of Action of Antivirals Against Nasopharyngeal Carcinoma at the Molecular Level. (International Medical University)    
(Top Down National Biotechnology Directorate – Medical Biotechnology Cooperative Centre).
Period: 2003-2007

Molecular and Allergen-Profile Study of Atopic Rhinitis.
(Short Term Study Grant) (University of Malaya)
Period: 2006-2007

Pharmacogenomics of Beta2-Adrenoceptor in Malaysian Asthmatics. (University of Malaya)
(E-Sciencefund - Ministry of Science, Technology and Innovation, Malaysia)
Period: 2007-2010

Stromal Expression of Serpin Proteins Play a Key Role in Breast and Prostate Cancer. (Strategic Grant Project 2010, Monash University, Clayton Australia)
Period: 2010-2011

Human genome in Multi-ethnic populations of Asia: A comprehensive Investigation of Human Genomic Variation in Multi-ethnic Malaysia towards Asian Anthropology, Healthcare and Preventive Medicine. (Monash University Malaysia)
(Top Down E-ScienceFund - Ministry of Science, Technology and Innovation, Malaysia)
Period: 2010-2013

Potential human anti-colorectal cancer agents from Malaysian pit vipers. (Monash University Malaysia) Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia
Period: 2014-2017

Ongoing

Identification of the pharmacophoric groups of an ideal GPER-1 ligand and its interaction mechanism with the receptor in breast cancer cells. (Monash University Malaysia) Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia
Period: 2015-2018

Neuroprotective and antioxidative nature of environmental enrichment exposure on diabetic and stressed rat hippocampus and identification of associated molecular pathways. (Monash University Malaysia) Fundamental Research Grant Scheme (FRGS) – Ministry of Higher Education, Malaysia
Period: 2016-2019

Exploration of the Therapeutic Potential of Semaphorin 5A in Human Glioblastomas. (Monash University Malaysia) (E-Sciencefund, Ministry Of Science, Technology and Innovation, Malaysia)
Period: 2015-2018

Research Supervision

Dr Aravind Yadav (MMedSc: 2004-completed) (University of Malaya)        
Title:  Molecular and Allergen Profile Study of Atopic Rhinitis.
Co-supervisor

Ms Lai Pey Jiun (MMedSc: 2004-completed) (University of Malaya)
Title:  Effect of Extracts from Selected Microalgae on Nasopharyngeal Carcinoma Cell Lines: Antineoplastic Activity and Gene Expression Analysis.
Main supervisor

Ms Lim Vin Nee (MSc(MedSc): 2005-completed) (International Medical University)          
Title: Expression of Selected Biomarkers and Their Correlation with Clinical-
Pathological Features of Colorectal Carcinoma Biomarkers in Malaysian Population.
Co-supervisor

Ms Vijaya Lechimi Raj (PhD: 2005-completed) (University of Malaya)
Title:  Molecular Characterisation and Functional Analysis of Selected Genes in Asthma.
Co-supervisor

Ms Ho Ching Ching (MMedSc: 2009-completed) (University of Malaya)      
Title:   Integrated Analysis of Copy Number and Loss of Heterozygosity, and Clinico-Pathological Analysis of Selected Genes in Primary Breast Carcinomas Using SNP Array.  
Co-supervisor

Dr Rafiq Salim Jabir (PhD: 2009-completed) (Universiti Putra Malaysia)
Title:   Pharmacogenetics of Docetaxel in Malaysian Breast Cancer Patients.
Co-supervisor

Felicia Simone Paulraj (PhD: 2011-completed) (Monash University Malaysia)
Title: Anti-cancer Activity and Mechanisms of Action of a Selected Diarylpentanoid Treated on Human Papillomavirus (HPV) Infected Human Cervical Cancer Cells.
Main supervisor

Farhang Aghakhanian Fereydani (PhD: 2011-completed) (Monash University Malaysia)
Title:   Genetic Structure and Variation in Negrito, SenoiaAnd Proto-Malay Ethnic Groups in Malaysia.  
Co-supervisor

Kamini Citalingam Mudliar (PhD: 2012-completed) (Monash University Malaysia)
Title: Anti-cancer Activity and Molecular Mechanisms of a Selected Diarylpentanoid Treated on Androgen-Independent Metastatic Human Prostate Cancer Cells.
Main supervisor

Syafiq Asnawi Zainal Abidin (PhD: 2013-completed) (Monash University Malaysia)
Title: Venom Proteome of Malaysian Pit Vipers (Calloselasma rhodostoma and Cryptelytrops purpureomaculatus) and Identification of Selected Proteins with Potential Anti-cancer Activity on Human Colon Cancer Cells  
Main supervisor

Ms Lara Chew Jin Hung (MBiomedSc: 2015-completed) (Monash University Malaysia)
Title:   Proteomic Profiling of a Selected Diarylpentanoid on Human Papillomavirus (HPV) infected Human Cervical Cancer Cells.
Main supervisor

Ms Fitya Syarifa Mozar (PhD: 2015-completed) (Monash University Malaysia)
Title: Delivery of Anti-cancer Drugs to Breast Cancer Cells Using pH-Sensitive Inorganic Nanoparticles.
Co-supervisor

Ms Farrah Shafeera Binti Ibrahim (PhD: 2014-present) (Monash University Malaysia)
Title: Identification of Early Potential Biomarker for Early Diabetic Nephropathy.
Co-supervisor

Ann Mary Bestus (PhD: 2016-present) (Monash University Malaysia)
Title: Developing the Therapeutic Potential of Semaphorin 5A in Human Glioblastomas.
Co-supervisor

Nurul Azwa Abd Wahab (PhD: 2017-present) (Monash University Malaysia)
Title: Molecular Mechanisms of a Selected Diarylpentanoid Treated on Androgen-independent Human Prostate Cancer Cells.
Main supervisor

Nor Isnida Binti Ismail (PhD: 2017-present) (Monash University Malaysia)
Title: Identification Mechanism of Action of a Selected Diarylpentanoid Treated on Human Colon Cancer Cells.
Main supervisor

Fathin Athirah Yusof (PhD: 2017-present) (Monash University Malaysia)
Title:  Identification of anticancer proteins from Malaysian Bungarus candidus and Bungarus fasciatus venom.
Co-supervisor

Wan Nur Baitty Wan Mohd Tajuddin (PhD: 2018-present) (Monash University Malaysia)
Title: Anti-proliferative Activities and Molecular Mechanisms of a Selected Curcumin Analogue on Human Lung Cancer Cells.
Main supervisor

Yee Qian Lee (MBiomedSc: 2018-present) (Monash University Malaysia)
Title: Anticancer mechanism of L-amino acid oxidase from Cryptelytrops purpureomaculatus on hormone-independent human breast and prostate cancer cells.
Main supervisor

Teh Rasyidah Binti Ismail (PhD: 2017-present) (Monash University Malaysia)
Title:  Neuroprotective and Antioxidative Nature of Environmental Enrichment Exposure on Diabetic and Stressed Rat Hippocampus and Identification of Associated Molecular Pathways.
Co-supervisor

Hammad Saleem (PhD: 2017-present) (Monash University Malaysia)
Title: Identification of Anti-cancer Constituents from Selected Medicinal Plants.
Co-supervisor

Shafi Ullah Khan (PhD: 2017-present) (Monash University Malaysia)
Title: Synthesis and Evaluation of Pharmacophore for GPER-1 Ligands with Anti-proliferative Activity in Breast Cancer.
Co-supervisor

Doryn Tan Meam Yee (PhD: 2016-present) (Monash University Malaysia)
Title: Development of Chitosan-Based Hydrogel Containing Nano-Formulations for Subcutaneous Delivery of Tocotrienols.
Co-supervisor

Awards, Fellowships and Honours

2008 American Association for Cancer Research-National Cancer Institute (AACR-NCI) International Investigator Opportunity Grants.