Associate Professor Dr. Anton V. Dolzhenko

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Associate Professor, Organic and Medicinal Chemistry 
School of Pharmacy

anton.dolzhenko@monash.edu
+603 5514 5867
Room  2-5-51

Anton V. Dolzhenko received his degree (with Distinction) in Pharmacy in 2000 and then a PhD degree in Medicinal Chemistry in 2004, both from the Perm State Pharmaceutical Academy (Russia). After that he joined the Pharmacy Department of the National University of Singapore and worked there for 6 years before he moved to the School of Pharmacy, Curtin University (Australia) in 2010 and continued his academic career as a Senior Lecturer. In 2013, he joined the School of Pharmacy, Monash University Malaysia. His current research interests include synthetic and structural aspects of chemistry of nitrogen heterocycles. He has been actively working on the development of new synthetic methods for the preparation of potentially bioactive compounds. His expertise in structural analysis of organic molecules and extensive experience drive Dr Dolzhenko to organize the NMR Campus Infrastructure Platform, which he leads now providing high quality service to internal and external customers.

Qualifications

- Graduate Certificate in Higher Education (GCHE), Monash University, 2016

- Doctor of Philosophy in Pharmaceutical Sciences, Perm State Pharmaceutical Academy, 2004

- Master of Pharmacy (with Distinction), Perm State Pharmaceutical Academy, 2000

Expertise

- Medicinal and organic chemistry

- Heterocyclic chemistry

- Green chemistry

- Microwave-assisted organic synthesis

- Multi-component reactions

-  Structural and physical organic chemistry

- NMR spectroscopy

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Book Chapters

Lim, F. P. L.; Dolzhenko, A. V.; Dolzhenko, A. V.* Development of New Enzyme Inhibitors: Purine Bioisostere Perspective. In: Pharmaceutical Formulation and Medicinal Chemistry: Mechanisms, Developments and Treatments, B. Moore, Ed., Nova Science Publishers, Inc., 2016, pp. 107-130 (ISBN: 978-1-63484-082-8)

Dolzhenko, A. V.,* Khan, T. M.; Dolzhenko, A. V. Strategies and Technologies for Preventing Plagiarism in Modern Higher Education: War against Today’s Plagiarists or Nurturing Tomorrow’s Talents. In: Handbook of Applied Learning Theory and Design in Modern Education, E. Railean, G. Walker, A. Elçi, and L. Jackson, Eds., IGI Global, 2016, pp. 857-882 (ISBN: 978-1-46669-634-1, EISBN: 978-1-46669-635-8) DOI: 10.4018/978-1-4666-9634-1.ch041.

Dolzhenko, A. V.;* Dolzhenko, A. V. Green solvents for eco-friendly synthesis of bioactive heterocyclic compounds. In: Green Synthetic Approaches for Biologically Relevant Heterocycles, Ed. G. Brahmachari, Elsevier, 2014, pp. 101-139 (ISBN: 978-0-12-800070-0).

Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Advances in chemistry and biological activity of fluorinated 1,3,5-triazines. In: Fluorine Chemistry Research Advances, Ed. I. V. Gardiner, Nova Science Publishers, NY, 2007, pp. 105-142. (ISBN: 1-60021-730-3)

Mikhailovskii, A. G.; Syropyatov, B. Ya.; Dolzhenko, A. V.; Shklyaev, V.S. Target synthesis and cardiovascular activity of isoquinoline and phenanthridine derivatives. In: Nitrogen-containing Heterocycles and Alkaloids, V.G. Kartsev, G.A. Tolstikov, Eds., Iridium-Press, Moscow, 2001, Vol. 1, pp. 393-397.

Scholarly Journals (Refereed Only)

Lim, F. P. L.; Kow, K. K.; Yeo, E. H.; Chow, S. C.; Dolzhenko, A. V.* Synthesis and antileukemic activity of new fluorinated 5-aza-9-deazapurines. Heterocycles, 2016, 92(6), 1121-1131, DOI: 10.3987/COM-16-13464.

Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A new, one-pot, multicomponent synthesis of bioactive N-pyrazolylformamidines under microwave irradiation. Synthesis, 2016, DOI: 10.1055/s-0035-1561616.

Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles. Tetrahedron Lett., 2015, 56(50), 7016-7019, DOI: 10.1016/j.tetlet.2015.11.006

Sachdeva, N.; Dolzhenko, A. V.; Lim, S. J.; Ong, W. L.; Chui, W. K. An efficient synthesis of 2,4,7-trisubstituted pyrimido[1,2-a][1,3,5]triazin-6-ones. New J. Chem., 2015, 39(6), 4796-4804, DOI: 10.1039/C5nj00405e

Dolzhenko, A. V.; Tan, B. J.; Chiu, G. N. C.; Chui, W. K.; Dolzhenko, A. V.* Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines. J. Fluorine Chem., 2015, 175, 68-72, DOI: 10.1016/j.jfluchem.2015.03.010

Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A one-pot, three-component aminotriazine annulation onto 5-aminopyrazole-4-carbonitriles under microwave irradiation. Tetrahedron Lett. 2015, 56(3), 521-524, DOI: 10.1016/j.tetlet.2014.12.010

Lim, F. P. L.; Dolzhenko, A. V.* 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity. Tetrahedron Lett. 2014, 55(49), 6684-6688, DOI: 10.1016/j.tetlet.2014.10.057

Lim, F. P. L.; Dolzhenko, A. V.* 1,3,5-Triazine-based analogues of purine: from isosteres to privileged scaffolds in medicinal chemistry. Eur. J. Med. Chem. 2014, 85, 371-390, DOI: 10.1016/j.ejmech.2014.07.112

Lim, F. P. L.; Luna, G.; Dolzhenko, A. V.* A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation. Tetrahedron Lett. 2014, 55(37), 5159-5163, DOI: 10.1016/j.tetlet.2014.07.105.

Bera, H.; Ojha, P. K.; Tan, B. J.; Sun, L.; Dolzhenko, A. V.; Chui, W. K.; Chiu, G. N. C. Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II. Eur. J. Med. Chem., 2014, 78, 294-303, DOI: 10.1016/j.ejmech.2014.03.063

Kalinina, S. A.; Elkina, O. V.; Kalinin, D. V.; Syropyatov, B. Ya.; Dolzhenko, A. V.* Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions. Pharm. Biol., 2014, 52(2), 191-198, DOI: 10.3109/13880209.2013.822001

Sun, L.; Li, J.; Bera, H.; Dolzhenko, A. V.; Chiu, G. N. C.; Chui, W. K. Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors. Eur. J. Med. Chem., 2013, 70, 400-410, DOI: 10.1016/j.ejmech.2013.10.022

Kalinina, S. A.; Kalinin, D. V.; Dolzhenko, A. V.* A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines. Tetrahedron Lett., 2013, 54(40), 5537-5540, DOI: 10.1016/j.tetlet.2013.07.158

Dolzhenko, A. V.*; Kalinina, S. A.; Kalinin, D. V. A novel multicomponent microwave-assisted synthesis of 5-aza-adenines. RSC Adv., 2013, 3(10), 15850-15855, DOI: 10.1039/c3ra41932k

Bera, H.; Dolzhenko, A. V.; Sun, L.; Gupta, S. D.; Chui, W. K. Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors. Chem. Biol. Drug Des., 2013, 82, 351-360, DOI: 10.1111/cbdd.12171

Bera, H.; Huey, L. M.; Sun, L.; Dolzhenko, A. V.; Chui, W. K. Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones. Bioorg. Chem., 2013, 50, 34-40, DOI: 10.1016/j.bioorg.2013.07.004. – Top 25 hottest articles in the journal (http://top25.sciencedirect.com/subject/chemistry/6/journal/bioorganic-chemistry/00452068/archive/48/)

Bera, H.; Chui, W. K.; Gupta, S. D.; Dolzhenko, A. V.; Sun, L. Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues. Med. Chem. Res., 2013, 22(12), 6010-6021, DOI: 10.1007/s00044-013-0589-1

Bera, H.; Tan, B. J.; Sun, L.; Dolzhenko, A. V.; Chui, W. K.; Chiu, G. N. C. A structure–activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities. Eur. J. Med. Chem., 2013, 67, 325-334, DOI: 10.1016/j.ejmech.2013.06.051

Kalinin, D. V.; Pantsurkin, V. I.; Syropyatov, B. Ya.; Kalinina, S. A.; Rudakova, I. P.; Vakhrin, M. I.; Dolzhenko, A. V.* Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides. Eur. J. Med. Chem., 2013, 63, 144-150, DOI: 10.1016/j.ejmech.2013.02.003

Kalinin, D. V.; Kalinina, S. A.; Dolzhenko, A. V.* A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide. Heterocycles, 2013, 87(1), 147-154, DOI: 10.3987/COM-12-12601

Kalinin, D. V.; Kalinina, S. A.; Dolzhenko, A. V.* Synthesis of novel trichloromethyl substituted azolo[1,3,5]triazines. Heterocycles, 2012, 85(10), 2515-2522, DOI: 10.3987/COM-12-12542

Dolzhenko, A. V.*; Bai, S. Q.; Dolzhenko, A. V.; Chui, W. K. Synthesis and structure of 3,4-dihydropyrido [2’,3’:3,4] pyrazolo[1,5-a][1,3,5]triazin-2-amines. J. Heterocycl. Chem., 2012, 49(4), 763-767, DOI: 10.1002/jhet.851

Syropyatov, B. Y.; Kolotova, N. V.; Dolzhenko, A. V. Effects of derivatives of succinic and maleic acids on blood coagulation. Vopr. Biol. Med. Farm. Khim., 2012, (5), 31-36.

Sachdeva, N.; Dolzhenko, A. V.; Chui, W. K. Regioselective synthesis of pyrimido[1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethyl orthoacetate: observation of an unexpected rearrangement. Org. Biomol. Chem., 2012, 10, 4586-4596, DOI: 10.1039/c2ob25195g

Cheong, S. L.; Dolzhenko, A.V.; Paoletta, S.; Lee, E. P. R.; Kachler, S.; Federico, S.; Klotz, K.-N.; Dolzhenko, A. V.; Spalluto, G.; Moro, S.; Pastorin, G. Does the combination of optimal substitutions at the C2-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors? Bioorg. Med. Chem., 2011, 19(20), 6120–6134, DOI: 10.1016/j.bmc.2011.08.026

Dolzhenko, A. V.*; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. Molecular and crystal structure of 7,7-dimethyl-2-pyridin-4-yl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine. Crystals, 2011, 1(3), 136-144, DOI: 10.3390/cryst1030136

Dolzhenko, A. V.* Synthetic routes towards pyrimido[1,2-a][1,3,5]triazines. Heterocycles, 2011, 83(7), 1489-1525, DOI: 10.3987/REV-11-701

Sachdeva, N.; Dolzhenko, A. V.; Chui, W. K. Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4-diamine. C. R. Chimie, 2011, 14(6), 580-587, DOI: 10.1016/j.crci.2010.10.003

Dolzhenko, A. V.*; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 7-(4-Fluorobenzylamino)-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol disolvate. Acta Crystallogr. 2011, E67, o1183-o1184, DOI: 10.1107/S1600536811014176

Dolzhenko, A. V.* Synthetic routes towards thiazolo[1,3,5]triazines. Heterocycles, 2011, 83(4), 695-738, DOI: 10.3987/REV-10-687

Dolzhenko, A. V.*; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one. Acta Crystallogr., 2011, E67(1), o85-o86, DOI: 10.1107/S1600536810051032

Dolzhenko, A. V.*; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 4,4-Dimethyl-3,4-dihydropyrido[2’,3’:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amine ethanol monosolvate. Acta Crystallogr., 2011, E67(1), o83-o84, DOI: 10.1107/S160053681005097X

Cheong, S. L.; Dolzhenko, A.; Kachler, S.; Paoletta, S.; Federico, S.; Cacciari, B.; Dolzhenko, A.; Klotz, K.-N.; Moro, S.; Spalluto, G.; Pastorin, G. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J. Med. Chem., 2010, 53(8), 3361-3375, DOI: 10.1021/jm100049f

Sachdeva, N.; Dolzhenko, A. V.*; Tan, G. K.; Koh, L. L.; Chui, W. K. 4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one. Acta Crystallogr., 2010, E66(8), o2050, DOI: 10.1107/S1600536810027522.

Dolzhenko, A. V.*; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. A monoclinic polymorph of N-ethoxycarbonyl-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea. Acta Crystallogr., 2010, E66(8), o1990-o1991, DOI: 10.1107/S1600536810026164

Dolzhenko, A. V.*; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Pastorin, G. 8-Methyl-2-[4-(trifluoromethyl)phenyl]-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine methanol disolvate. Acta Crystallogr., 2010, E66(7), o1835-o1836, DOI: 10.1107/S1600536810024591

Bera, H.; Dolzhenko, A. V.*; Tan, G. K.; Koh, L. L.; Chui, W.K. 4-Carbethoxy-1-[4-(N,N-dimethylamino) benzoyl]thiosemicarbazide. Acta Crystallogr., 2010, E66(5), o1241, DOI: 10.1107/S1600536810015576

Dolzhenko, A. V.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Pastorin, G. N'-Acetyl-5-amino-1-methyl-1H-pyrazole-4-carbohydrazonamide dihydrate. Acta Crystallogr., 2010, E66(5), o1209-o1210, DOI: 10.1107/S1600536810015357

Dolzhenko, A. V.*; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. N-Carbethoxy-N'-[3-(4-methylphenyl)-1H-1,2,4-triazol-5-yl]thiourea. Acta Crystallogr., 2010, E66(3), o549-o550, DOI: 10.1107/S1600536810004289

Dolzhenko, A. V.*; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. N-Carbethoxy-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea. Acta Crystallogr., 2010, E66(2), o425,

Local Grants

A. V. Dolzhenko, S. C. Chow, I. B. Othman, N. Ahemad. 2015-2017. Synthesis of 5-azapurine derivatives as new modulators of purinergic receptors, Fundamental Research Grant Scheme (FRGS) Ministry of Higher Education, Malaysia, , RM152,300.00

A. V. Dolzhenko, S. C. Chow. 2015.  Purine metabolism as target for the treatment of the parasite Toxoplasma, Tropical Medicine, Biology and Genomics Platform Seed Grant , Monash University Malaysia, RM10,000.00

A. V. Dolzhenko, S. C. Chow, I. B. Othman, K. S. Tang, R. Mancera (Curtin University).  2014-2016.  Heterocyclic purine analogues: xanthine oxidase substrates or inhibitors?, Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education, Malaysia, RM83,000.00

M. Bt Mohd Diah, N. I. Nordin, A. V. Dolzhenko, T. W. Wong.  2014-2015.  Design of chitosan derivative-5-fluorouracil conjugate for topical treatment of skin cancer, Science Fund Grant, Ministry of Science, Technology and Innovation, Malaysia, RM256,000.00

International Grant

A. V. Dolzhenko.  2013.  Using microwave irradiation for the synthesis of purine isosters, Microwave-enhanced chemistry grant program of CEM Corporation, USA, US$2,000.00

D. V. Kalinin (Trainee), A. V.Dolzhenko (Supervisor). 2011-2012.  Synthesis of bioactive condensed heterocyclic molecules using alfa-cyanoheterylamines as synthons, Russian President Grant for traineeship abroad, AU$21,500.00

S. A. Kalinina (Trainee), A. V.Dolzhenko (Supervisor).  2011-2012.  Synthesis of bioactive pyrimido[1,2-a]triazines and their analogues, Russian President Grant for traineeship abroad, AU$21,500

A. V. Dolzhenko.  2011.  Microwave-assisted synthesis of polyaza heterocyclic compounds of biological importance, Microwave-enhanced chemistry grant program of CEM Corporation, USA, US$ 2,000.00

G. Pastorin, A. V. Dolzhenko, G. Spalluto, S. Moro, W. K. Chui.  2011.  Investigation of new lead compounds as adenosine receptors antagonists and their potential application in the treatment of neurodegenerative diseases, Grant of the National Medical Research Council (NMRC) of Singapore, S$ 200,000.00

W. K. Chui, G. N. C. Chiu, A. V. Dolzhenko.  2011.  Synthesis and bioactivity evaluation of new 1,3,5-triazine-2,4-diones and their analogues as potential inhibitors of thymidine phosphorylase for anticancer chemotherapy, Grant of the National Medical Research Council (NMRC) of Singapore, S$ 197,000.00

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Engagement With Premier Public Universities

Visiting Faculty, 2016-present  
Faculty of Pharmacy, South Ural State Medical University, Russian Federation

Adjunct Senior Lecturer, 2013-present  
School of Pharmacy, Curtin University, Australia

Membership in Academic Editorial Committees

Editor-in-Chief, Current  
Advances in Chemistry and Biochemistry Sciences

Editorial Board Member, Current  
International Journal of Pharmacy

Editorial Board Member, Current  
American Journal of Organic Chemistry

Editorial Board Member, Current  
Journal of Crystallography

Editorial Board Member, Current  
SOP Transactions on Organic Chemistry

Editorial Board Member, Current  
International Research Journal of Pure and Applied Chemistry

Editorial Board Member, Current  
International Journal of Bioorganic Chemistry & Molecular Biology

Editorial Board Member, Current  
Mendeleev Journal of Chemistry

Editorial Board Member, Current  
International Journal of Drug Discovery and Pharmacy

Editorial Board Member, Current  
International Journal of Innovation Medicinal Plant Research

Editorial Board Member, Current  
International Journal of Innovation Pharmacy and Pharmacology

Editorial Board Member, Current  
Journal of Applied Chemical Science International

Reviewer, Current  
Organic and Biomolecular Chemistry

Reviewer, Current  
RSC Advances

Reviewer, Current  
New Journal of Chemistry

Reviewer, Current  
Synlett

Reviewer, Current  
Tetrahedron Letters

Reviewer, Current  
Bioorganic and Medicinal Chemistry Letters

Reviewer, Current  
European Journal of Medicinal Chemistry

Reviewer, Current  
Toxicology and Applied Pharmacology

Reviewer, Current  
Journal of Heterocyclic Chemistry

Reviewer, Current  
Australian Journal of Chemistry

Reviewer, Current  
European Journal of Chemistry

Reviewer, Current  
Current Organic Synthesis

Reviewer, Current  
Comptes Rendus - Chimie

Reviewer, Current  
Medicinal Chemistry

Reviewer, Current  
Letters in Drug Design & Discovery

Reviewer, Current  
Journal of Enzyme Inhibition and Medicinal Chemistry

Reviewer, Current  
Combinatorial Chemistry & High Throughput Screening

Reviewer, Current  
Heterocyclic Communications

Reviewer, Current  
Molecules

Reviewer, Current  
Journal of Medicinal Plants Research

Reviewer, Current  
Journal of Chemistry, Biochemistry and Molecular Biology

Reviewer, Current  
Journal of Autacoids and Hormones

Reviewer, Current  
Pharmaceutical Biology

Reviewer, Current  
Open Pharmaceutical Sciences Journal

Reviewer, Current  
Journal of the Brazilian Chemical Society

Reviewer, Current  
International Journal of Developmental Neuroscience

Reviewer, Current  
Green Chemistry Letters and Reviews