Dr. Alan Yiu Wah Lee

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Senior Lecturer 
School of Pharmacy

alan.lee@monash.edu
+603 5514 4417
Room  2-5-37

The long-term goal of Dr. Lee’s research team is to understand the functions of neuronal axon guidance molecules in the nervous systems during physiological and pathological conditions. His recent research interests include the role of guidance molecules in neuronal and glial differentiation, in cancer progression and in CNS regeneration. A combination of various approaches, ranging from cell and molecular biology, molecular genetics, animal models and controlled drug delivery are used in these studies.

Qualifications

- Doctor of Philosophy, The University of Hong Kong

- Bachelor of Science, The University of Hong Kong

Expertise

- Molecular genetics

- Molecular medicine

- Cell motility

- Neuronal axon guidance

- Brain cancer

- CNS regeneration

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Book Chapters

Lee, A. Y. “The involvement of guidance molecules in adult brain neurogenesis”. In Neurogenesis, Neurodegeneration and Neuroregeneration. Research Signpost, 2010. pp. 27-41.

Scholarly Journals (Refereed Onley)

Law, J.W. and Lee, A.Y. (2012) The role of semaphorins and their receptors in gliomas. J. Signal Transduct.vol. 2012, Article ID 902854.

Li, X, Law, J.W, and Lee A.Y. (2012) Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. Oncogene31, 595-610. https://doi.org/10.1038/onc.2011.256

Li, X. and Lee, A.Y. (2010) Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIα-mediated inactivation of Rac1 GTPase. J. Biol. Chem. 285, 32436-45. https://doi.org/10.1074/jbc.M110.120451

Chong, K. W., Chen, M. J., Koay, E. S., Wong, B. S., Lee, A. Y., Russo-Marie, F., and Cheung, N. S. (2010) Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury. Neurosci. Letters 485, 129-133.https://doi.org/10.1016/j.neulet.2010.08.089

Chew, J., Chen, M. J., Lee, A. Y., Peng, Z. F., Chong, K. W., He, L., Bay, B. H., Ng, J. M., Qi, R. Z., and Cheung, N. S. (2010) Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator. J. Cell. Biochem. 111, 1359-1366.  https://doi.org/10.1002/jcb.22864

Tan, E.Y., Law, J. W., Wang, C.H. and Lee, A. Y. (2007) Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons. Pharm. Res. 24, 2297-2308. https://doi.org/10.1007/s11095-007-9454-6

National Research Grant

Alan Lee Yiu Wah Lee, 2015-2017, Exploration of the therapeutic potential of semaphorin 5A in human glioblastomas, eScience Fund, Ministry of Science, Technology and Innovation, Malaysia, RM308,300.00

Alan Lee Yiu Wah Lee, 2013-2016, Deciphering the mechanisms of tumor suppressor effects of semaphorin 5A in human gliomas, Fundamental Research Grant Scheme, Ministry of Education, Malaysia, RM150,000.00

Postgraduate (MSc and PhD)

Amrutha Menon (PhD: Completed - 2018) 
Investigation of the mechanisms underlying downregulation of the tumor suppressor protein Sema5A in human glioblastomas
- Main Supervisor

Ann Mary Bestus (PhD: Nov 2016 - present) 
Developing the therapeutic potential of semaphorine 5A in human glioblastomas
- Main Supervisor

Membership in Academic Editorial Committees

Reviewer, 2013   
Toxicology and Applied Pharmacology

Review Editor, 2010 
Frontiers in Neurotrauma, 2010

Membership in Professional Bodies

Member, 2002 
Society for Neuroscience