Dr. Alice Chuah Lay Hong

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Senior Lecturer (Pharmaceutics)
School of Pharmacy

alice.chuah@monash.edu
+603 5514 4454
Room  2-5-49

Dr. Alice Chuah is a senior lecturer in the School of Pharmacy. She is a registered pharmacist in Malaysia, and has had experience working in hospital and community pharmacies. During her PhD studies, she was awarded the World Federation of Scientist (WFS) Scholarships for two consecutive years. She also received the Malaysia National Cancer Council (MAKNA) Cancer Research Award in 2009. Her research focusses on novel drug delivery systems for natural compounds. Her teaching philosophy is to nurture independent thinkers and life-long learners.

Qualifications

- Graduate Certificate in Higher Education (GCHE), Monash University, Malaysia, 2016

- Doctor of Philosophy in Pharmacy, University of Nottingham, 2013

- Master of Pharmacy, University of Strathclyde, 2007

Expertise

- Drug formulation and delivery

- Nanoparticle

- Curcumin

- Tocotrienol

- Natural compounds

- Cancer

- Chitosan

- Pharmaceutical Analysis

Awards and Honours

2011-2012

  • World Federation of Scientists (WFS) Scholarship,World Federation of Scientists, Geneva.  Application of nanoparticular mucoadhesion in the delivery of anticancer agent for the treatment of colorectal cancer.

2010-2011

  • World Federation of Scientists (WFS) Scholarship,World Federation of Scientists, Geneva.  Application of nanoparticular mucoadhesion in the delivery of anticancer agent for the treatment of colorectal cancer.

2009

  • MAKNA Cancer Research Award, Malaysian National Cancer Council (MAKNA),  Application of nano-particular mucoadhesion in the delivery of anticancer agent for the treatment of colorectal cancer.

Research Interest

My primary research area is to develop drug delivery systems for natural compounds. There is an abundace of natural compounds with proven therapeutic effects that have failed to bring their benefits to end users. These are often limited by the compound properties as well as inappropriate formulations. I believe that the key to this is through improved formulation of such compounds to overcome the limitations of poor solubility, poor absorption and poor bioavailability.

Research Projects

Current Projects

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The development and evaluation of novel radiolabeled nano-formulations for use in nuclear imaging

This project aims to develop a radiolabled nano-formulation suitable for use in nuclear imaging. Successful development of such nano-formulation allows its use as a nano drug carrier for therapeutic purposes. Radiolabeled nano-formulation can be viewed and tracked in animal for biodistribution studies.

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Fabrication of wound dressing membrane

This project will develop a wound dressing membrane incorporating natural wound healing compound. The membrane is biodegradable and is easy to use, suitable for patients to change the dressing at their convenience.

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Scholarly Journals (Refereed Only)

Saw, P.S., Chuah, L.H., Lee, S.W.H., 2018. A practical approach toward teaching ethics to community pharmacists. International Journal of Clinical Pharmacy, 40: 1131-1136. https://doi.org/10.1007/s11096-018-0707-8

Sathasivam, T., Muniyandy, S., Janarthanan, P, Chuah, L.H., 2018. Spray dried solid dispersions of piroxicam in carboxymethyl sago cellulose using aqueous solvents: A simple, novel and green approach to produce enteric microparticles with enhanced dissolution. Drying Technology, Doi:10.1080/07373937.2018.1492613

T Sathasivam, S Muniyandy, LH Chuah, P Janarthanan (2018). Encapsulation of red palm oil in carboxymethyl sago cellulose beads by emulsification and vibration technology: Physicochemical characterization and in vitro digestion. Journal of Food Engineering, 231: 10-21

DSL Ma, LTH Tan, KG Chan, WH Yap, P Pusparajah, LH Chuah, LC Ming, TM Khan, LH Lee, BH Goh (2018). Resveratrol – Potential antibacterial agent against foodborne pathogens. Frontiers in Pharmacology, 9: 102  https://doi.org/10.3389/fphar.2018.00102

Heng, S.-P., Letchumanan, V., Deng, C.-Y., Mutalib, N.-S.A., Khan, T.M., Chuah, L.-H., Chan, K.-G., Goh, B.-H., Pusparajah, P., Lee, L-H., 2017. Vibrio vulnificus - An environmental and clinical burden. Frontiers in Microbiology, 8: 997.

Law, J.W.-F., Ser, H.L., Khan, T.M., Chuah, L.-H., Pusparajah, P., Chan, K.G., Goh, B.H., Lee, L-H., 2017. ).  The potential of Streptomyces as biocontrol agents against the rice blast fungus, Magnaporthe oryzae  (Pyricularia oryzae). Frontiers in Microbiology, 8, 3.

SHM Wong, CM Fang, L-H Chuah, CO Leong, SC Ngai (2018). E-cadherin: its dysregulation in carcinogenesis and clinical implications. Critical Review in Oncology / Hematology, 121: 11-22  https://doi.org/10.1016/j.critrevonc.2017.11.010

Y-S Wu, S-C Ngai, B-H Goh, K-G Chan, L-H Lee, L-H Chuah. Anti-cancer activity of surfactin and potential application of nanotechnology assisted surfactin delivery (2017). Frontiers in Pharmacology, 8: 761 https://dx.doi.org/10.3389%2Ffphar.2017.00761

LTH Tan, KG Chan, P Pusparajah, W-L Lee, L-H Chuah, TM Khan, L-H Lee, BH Goh (2017). Targeting membrane lipid a potential cancer cure? Frontiers in Pharmacology, 8: 12 https://dx.doi.org/10.3389%2Ffphar.2017.00012

J-Y Fu, T-T Htar, L De Silva, DM-Y Tan, L-H Chuah (2017). Chromatographic Separation of Vitamin E Enantiomers. Molecules, 22, 2. https://doi.org/10.3390/molecules22020233

De Silva, L., Chuah L.H., Meganathan, P., Fu, J-Y. (2016). "Tocotrienol and metastasis", Biofactors, 4(42), pp. 149-162.

L.H. Chuah, L. De Silva, M. Saravanan, J-Y. Fu. (2015). "Preparation and optimization of tocotrienol rich fraction (TRF)-loaded niosomes", Asian Journal of Pharmaceutical Sciences, 11(1), pp. 56-57.

Chuah, L.H., Roberts, C.J., Billa, N., Abdullah, S., Rosli, R. (2014). "Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles", Colloids Surf B, 116, pp. 228-236.

Chuah, L.H., Roberts, C. J., Billa, N., Abdullah, S., Rosli, R., Manickam, S. (2014). "Using Nanoparticle Tracking Analysis (NTA) to decipher mucoadhesion propensity of curcumin-containing chitosan nanoparticles and curcumin release", J Disper Sci Technol, 35(9), pp. 1201-1207.

Chuah, L.H., Billa, N., Roberts, C. J., Burley, J.C., Manickam, S. (2011). "Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon", Pharm Dev Technol, pp. 1–9. https://doi.org/10.3109/10837450.2011.640688

Chuah, L.H., Billa, N., Manickam, S. (2011). "Effects of homogenisation and ultrasonication on curcumin-containing nanoparticles", J Ind Technol, 20(1), pp. 1-11.

Conference Proceedings (Refereed Only)

L. De Silva, L.H. Chuah, J-Y Fu, T.T. Htar, A. Kasbollah, W.H.B. Kamal, M.F. Fadzil, P. Eu, L.I. Wiebe (2016). "Optimization of mobile phase condictions for a thin layer chromatography (TLC) method for radioassay of 99m-technetium labelled niosomes", International Conference of Translational Molecular Imaging and Aero-Space Medicine & Physiology Showcase (ICT-MIPS), April 2016, Kuala Lumpur, Malaysia.

L. De Silva, L.H. Chuah, M, Saravanan, J.Y. Fu (2015). "Preparation and Characterization of Span 60-cholesterol-TPGS niosomes", Controlled Release & Drug Delivery Symposium, August 2015, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Chuah, L.H., Roberts, C.J., Billa, N., Abdullah, S., Rosli, R. (2014). "Improved cellular uptake of curcumin into colorectal cancer cells when formulated in mucoadhesive chitosan nanoparticles", 5th FIP Pharmaceutical Sciences World Congress (PSWC), April 2014, Melbourne, Australia.

Chuah, L.H., Billa, N., Rosli, R., Abdullah, S., Roberts, C.J., Burley, J.C. (2012). "Mucoadhesive curcumin-containing nanoparticles as a potential treatment for colorectal cancer", The Federation of Asian Pharmaceutical Associations Congress (FAPA), September 2012, Bali, Indonesia.

Chuah, L.H., Billa, N., Roberts, C.J., Burley, J.C., Manickam, S. (2011). "Mucoadhesion study on curcumin-containing chitosan nanoparticles for possible delivery to the colon", UK PharmSci conference, September 2011, Nottingham, United Kingdom.

Chuah, L.H., Billa, N., Manickam, S. (2009). "Effects of homogenisation and ultrasonication on curcumin-chitosan nanoparticles", Proceedings of the International Conference on Nanotechnology (iCONT), December 2009, Langkawi, Malaysia.

Research Grants (Principle Investigator)

Chuah, L.H., Chow, S.E., Dolzhenko, A., Ting, S.Y., Fu, J.Y., 2018-2020: New Strategy for the efficient and safe preparation of carbendazim and its analogues as agents for crop protection with a potential for repurposing as anticancer therpeutics, FRGS, MOHE

Dr. Alice Chuah, Dr. Poh Phaik Eong, Dr. Fu Ju Yen, 2018.  Fabrication of Tocotrienol Wound Dressing Membrane, Advanced Engineering Platform, Monash University Malaysia, RM45,000.00

Dr. Alice Chuah, 2017-2018.  Transforming Pharmacy Teaching & learning through Online Interactive Module, Monash Education Academy, RM6,000.00

Dr. Alice Chuah, Dr. Poh Phaik Eong, Dr. Fu Ju Yen, 2018.  Fabrication of Tocotrienol Wound Dressing Membrane, Advanced Engineering Platform, Monash University Malaysia, , RM15,000.00

Dr. Alice Chuah Lay Hong, Dr. Fu Ju Yen, Assoc. Prof. Ong Chin Eng, Dr. Saravanan Muniyandy, Prof. Iekhsan bin Othman, Dec 2014 - Nov 2016.  Evaluation of targeting efficacies and distribution of targeted nano-formulations using nuclear imaging techniques, FRGS, Ministry of Higher Education, RM90,000.00

Research Grants (Co-investigator)

Dr. Shaun Lee, Dr. Alice Chuah, Ms Saw Pui San, 2017.  Monash University Pharmacist Continuing Education Studies: Moral Dilemma in Pharmacy, Pfizer Independent Learning Grants for Learning and Change, USD13,300.00

Prof. Nathorn Chaiyakunapruk, Dr. Alice Chuah, Dr. Tahir Mehmood Khan, 2017-2019.  The clinical effects of tocotrienols in human studies: a systematic review, Malaysian Palm Oil Board (MPOB), RM99,000.00

Dr. Thet Thet Htar, Assoc. Prof. Rakesh Naidu a/l Kuppusamy Naidu, Dr. Nafees Ahemad Mohammed Yunus, Dr. Alice Chuah Lay Hong, Nov 2015 - Oct 2018.  Identification of the pharmacophoric groups of an ideal GPER-1 ligand and its interaction mechanism with the receptor in breast cancer cells, FRGS, Ministry of Higher Education, RM145,000.00

Dr. Vivienne Mak (PI), Dr. Shaun Lee, Dr. Alice Chuah, Dr. Safeera Hussainy, Prof. Carl Kirkpatrick, Feb 2016 - Jan 2017.  Development of an online interactive learning module in the teaching of extemporaneous dispensing, Better Teaching, Better Learning Small Grants Scheme, Monash Education Academy, AUD5,000.00

Postgraduate (MSc and PhD)

Camille Keisha Mahendra (PhD: 2018-present)
Molecular Characterization And Validation Of Exome Variants In Primary Antiphospholipid Syndrome (APS) Patients
- Co-Supervisor

Shafi Ullah Khan (PhD: 2017-present)
Synthesis and evaluation of pharmacophore requirement of GPER-1 ligands for anti-cancer activity
- Co-Supervisor

Doryn Tan Meam Yee (PhD: 2017-present)
Development of chitosan-based hydrogel containing nano-formulations for subcutaneous delivery of tocotrienols
- Main supervisor

Ahmad Junaid (PhD: 2015-present)
Potential Therapeutic Application of Purine Bioactive compound against Uric acid disorders
- Co-Supervisor

Leanne Sabrina De Silva (MSc: Completed)
The Development and Evaluation of Novel Radiolabeled Niosomes as Potential Nano-carriers for Biodistribution Studies in Breast Cancer Murine Xenografts
- Main supervisor

Thenapakiam Sathasivam (PhD: completed)
Semi-Synthetic Polymers From Metroxylon Sagu Biomass As Pharmaceutical Excipient In Making Vegetarian Capsules And Enhancing Dissolution Of Poorly Water Soluble Drug
- Main supervisor

Felicia Lim Phei Lin (PhD: completed)
Synthesis of bioactive purine-like fused azoles
- Co-Supervisor

Amrutha Menon (PhD: completed)
Identification and validation of miRNAs that downregulate expression of the tumor suppressor protein Semaphorin 5A in human glioblastomas
- Co-Supervisor

Membership in Academic Editorial Committees

Associate Editor, 2017-2018
Frontiers in Pharmacology

Membership in International/National Bodies

Ambassador, 2017-present  
European

Product Advisor, 2016-present   
Biotechnology Division, Biotek Abadi Sdn Bhd

Workshop Organisers

29 Sep, 2017.  Workshop organiser for “Monash University Pharmacist Continuing Education Studies Workshop: Moral Dilemma in Pharmacy” at Sunway Resort Hotel & Spa, Selangor.


21 Oct, 2016.  Workshop organiser for “Monash University Pharmacist Continuing Education Studies Workshop: Medication Management in the Elderly” at Sunway Resort Hotel & Spa, Selangor.


4 Dec 2015.  Workshop organiser for “Pharmacist Education Program: Train-the-Trainer Workshop – Update on Cardiovascular diseases and delivery of medication review services” at Sunway Resort Hotel & Spa, Selangor.

Invited Speaker

5-8 Sep, 2017.  Lecture for postgraduate students. Topic: “Nano-formulations to deliver natural compounds for anticancer treatment”, at Ubonratchathani University, Thailand.


21 Oct, 2016.  Monash University Pharmacist Continuing Education Studies workshop. Topic: “Dosage forms in older adults”, at Sunway Resort Hotel & Spa