Dr. Nafees Ahemad

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Senior Lecturer (Medicinal Chemistry)
School of Pharmacy

nafees.ahemad@monash.edu
+603 5514 5883
Room  2-5-14

Dr. Nafees has joined MONASH University Malaysia (MUM) on September 2012. He obtained M.S. (Pharm) and PhD in Natural Products chemistry/Medicinal Chemistry from National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. He worked on total synthesis of natural products, synthesis of new chemical analogues for discovery of new anti-HIV agents based on natural products templates. Before joining MUM as lecturer, he was a Postdoctoral Research Fellow in Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM) Penang. His current areas are computational based rational design of new drug candidates for HIV-1, dengue and other therapeutics.

Qualifications

- Doctor of Philosophy,  National Institute of Pharmaceutical Education and Research (NIPER), India, 2011

- Master of Science (Pharm), National Institute of Pharmaceutical Education and Research (NIPER), India, 2005

- Bachelor of Pharmacy, University of Pune, 2003

Expertise

- Computer Aided Drug Design and synthesis of New Chemical Entities (NCE

- Lead optimization to explore the functions of biologically active natural products as well as synthetic compounds

- Total synthesis of biologically active natural products

- Molecular docking and computational simulation studies

Patents

“Novel anti-HIV compounds.” K. K. Bhutani, N. Ahmed, K. G. Brahmbhatt, I. P. Singh, D. Mitra, S. Sabede. Application No.1556/DEL/2009 28-07-2009.

“Novel alkylated derivatives of quinoline 2,4-diol with anti-HIV activity.” K. K. Bhutani, N. Ahmed, K. G. Brahmbhatt, I. P. Singh, D. Mitra, S. Sabede. Application No.1557/DEL/2009 28-07-2009.

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Book Chapters

Chapter 19: Ajwain  (Trachyspermum ammiL.) Oils” Sirajudheen Anwar, Nafees Ahmed, Sofiane Habibatni and Yousef Abusamra., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 181-192.

“Chapter 29: Bitter Orange (Citrus aurantiumL.) Oils” Sirajudheen Anwar, Nafees Ahmed, Antonio Speciale, Francesco Cimino and Antonella Saija., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 259-268.

“Chapter 55: Jasmine  (Jasminum sambac L,Oleaceae) Oils” Nafees Ahmed, Yousef A. Hanani, Shabana Y. Ansari and Sirajudheen Anwar., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 487-494

“Chapter 66: Myrtle  (Myrtus communis L.) Oils” Sirajudheen Anwar, Nafees Ahmed, Nasir Al Awwad, Shabana Y. Ansari and Mohamed E. Wagih., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 581-592.

“Chapter 80: Saffron Crocus (Crocus sativus) Oils” Nafees Ahmed, Sirajudheen Anwar, Said Saleh Alsokari, Shabana Y. Ansari and Mohamed E. Wagih., 2016 Book named “Essential Oils in food production, preservation, flavour and safety”. Edited by Victor R. Preedy (Department of Nutrition and Dietetics, King’s College London, London, UK). Publisher: Elsevier publication Academic Press, San Diego, CA 92101-4495, USA, ISBN: 978-0-12-416641-7, Page no. 705-714.

Scholarly Journals

Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong (2019).  Expression of cytochrome P450 2C9 (CYP2C9) in Escherichia coli and its functional characterization.  Asia Pacific Journal of Molecular Biology & Biotechnology. Accepted 2019.

Hammad Saleem; Gokhan Zengin; Marcello Locatelli; Adriano Mollica; Irshad Ahmad; Fawzi M. Mahomoodally; Syafiq Asnawi; Nafees Ahemad (2019).  In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents.  Ind Crops Prod. 2019, 130, 9-15.

Shafi Ullah Khan, Nafees Ahemad, Lay-Hong Chuah, Rakesh Naidu, Thet Thet Htar (2019).  Sequential ligand- and structure-based virtual screening approach for the identification of potential G protein-coupled estrogen receptor-1 (GPER-1) modulators.  RSC Advances 2019, 9, 2525-2538.

Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Irshad Ahmad, Muhammad Ashraf, Nafees Ahemad (2019).    Investigations into the therapeutic effects of aerial and stem parts of Buxux papillosa C.K. Schneid.: In vitro chemical, biological and toxicological perspectives.  Journal of Pharmaceutical and Biomedical Analysis 2019, 166, 128-138.

Hammad Saleem, Irshad Ahmad, Gokhan Zengin, Fawzi M. Mahomoodally, Hafiz Muhammad Ahsan, Syafiq Asnawi Zainal Abidin, Nafees Ahemad (2019).  Comparative secondary metabolites profiling and biological activities of aerial, stem and root parts of Salvadora oleoides Decne (Salvadoraceae).   Natural Product Research 2019 https://doi.org/10.1080/14786419.2018.1564299

Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Nurziana Sharmilla Nawawi, Irshad Ahmad, Muhammad Ashraf, Nafees Ahemad (2019).  Biological, chemical and toxicological perspectives on aerial and roots of Filago germanica: Functional approaches for novel phyto-pharmaceuticals.  Food and Chemical Toxicology 2019, 123, 363-373.

Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Gokhan Zengin, Irshad Ahmad, Nafees Ahemad (2019).  Phytochemical profiling, antioxidant, enzyme inhibition and cyto‐ toxic potential of Bougainvillea glabra flowers.  Natural Product Research 2019.  10.1080/14786419.2018.1543684

S. Anwar, H R Madkor, N. Ahmed, M E Wagih (2018).  In vivo anticlastogenic effect of silymarine from milk thistle Silybum marianum L.  Ind J of Pharmcol. 2018, 50 (3), 108-115. https://doi.org/10.4103/ijp.IJP_660_16

Amelia Nathania Dong, Yan Pan, Uma Devi Palanisamy, Beow Chin Yiap, Nafees Ahemad, Chin Eng Ong (2018).  Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants.  Applied Biochemistry and Biotechnology, 2018, 186(1), 132-144.

Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong (2018).  Cytochrome P450 2C9‐natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data. Biopharmaceutics and Drug Disposition. 2018, 39(4), 205-217.

Yap WH, Ooi BK, Ahmed N, Lim YM (2018).  Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation.  J Biosci. 2018, 43(2), 277-285.

Wei Hsum Yap, Su Wen Phang, Nafees Ahmed, Yang Mooi Lim (2018).  Differential effects of sPLA -GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells.  Molecular and Cellular Biochemistry 2018, 1-9.

Waqas Mahmood, Hammad Saleem, Shoaib Ali Gill, Sadia Chuman Seema Abbas, Anam Mubashar, Shafi Ullah Khan and Nafees Ahemad (2018).  In vitro Studies on Acetylcholinesterase and Butyrylcholinesterase Inhibitory Potentials of Aerial Parts of Vernonia oligocephala (Asteraceae).   Trop, J Pharm. Res. 2018, 17912), 2445-2448.

Nafees Ahmed, Sirajudheen Anwar, Thet Thet Htar (2017).  Docking based 3D-QSAR study of tricyclic guanidine analogues of batzelladine K for antimalarial activity Front. Chem. 2017, 5, 1-6.

Wei Hsum Yap, Nafees Ahmed & Yang Mooi Lim (2016).  Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid.  Lipids (2016) 51:1153–1159.  https://doi.org/10.1007/s11745-016-4186-1

Saralla Nathan, Md. Ezharul Hoque Chowdhury, Anuar Zaini Md Zain, Iekhsan Othman, Sharifah Binti Syed Hassan, Nafees Ahmed (2016).  Protein thaw loss in meat systems: Biochemical influence towards meat authentication of fresh versus thawed.  International Food Research journal.  2016, Accepted in Press.

Saravanan Muniyandy, Ng Khuenyen, Christina Gertrude Yap, Moriya Shogo, Nafees Ahemed, Md Ezharul Hoque Chowdhury,Ahmad Farouk Musa (2015).  Influence of YouTube videos on the learning of tablet-and capsule-formulation by Malaysian pharmacy students: A pilot study. Pharmacy Education, 2015; 15 (1) 248 – 251.

Nafees Ahmed, Shabana I. Khan, Kamlesh K. Bhutani (2014).  Synthesis, Biological Evaluation and Molecular Docking Studies of Tricyclic Guanidine Derivatives for Anti-Malarial Activity.  Asian Pac J Trop Dis 2014; 4(3): 233.

Kai Hung Tiong, Nafees Ahemad, Beow Chin Yiap, Eng Lai Tan, Rusli Ismail, and Chin Eng Ong (2014).  Inhibitory Potency of 8-Methoxypsoralen on Cytochrome P450 2A6 (CYP2A6) Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential Susceptibility Due to Different Sequence locations of the Mutations.  PLOSONE 2014, 9(1), 1-8.

N. Ahmed, K. G. Brahmbhatt, S. I. Khan, M. Jacob, B. Tekwani, S. Sabde, D. Mitra, I. P. Singh, I. A. Khan, K. K. Bhutani (2013). Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities.  Chem. Biol. Drug Des. 2013; 81: 491-498. DOI:10.1111/cbdd.1427

S. Sabde, H. S. Bodiwala, A. Karmase, P. Deshpande,  A. Kaur, N. Ahmed, S. K. Chauthe, K. G. Brahmbhatt, R. U. Phadke, D. Mitra, K. K. Bhutani, I. P. Singh (2011).  Anti-HIV activity of Indian medicinal plants.  J. Nat. Med. 2011, 65 (3-4), 662-669.  DOI:10.1007/s11418-011-0513-2

N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani (2010).  Efficient chemoselective alkylation of quinoline 2,4-diol derivatives in water.  J. Heterocyl. Chem. 2011, 48, 237-240.

K. G. Brahmbhatt, N. Ahmed, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani (2010).  Synthesis and evaluation of β–carboline derivatives as inhibitors of human immunodeficiency virus.  Bioorg. Med. Chem. Lett. 2010, 20, 4416-4419.  https://doi.org/10.1016/j.bmcl.2010.06.052

N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani (2010).  Total Synthesis of (±) Batzelladine K: A Biomimetic Approach.  Synthesis 2010, 15, 2567-2570.

N. Ahmed, K. G. Brahmbhatt, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani (2010).  Synthesis and Anti-HIV Activity of Alkylated Quinoline 2,4-diols. Bioorg. Med. Chem. 2010, 18, 2872-2879. (Among Top 25 most downloadable research papers).  https://doi.org/10.1016/j.bmc.2010.03.015

K. G. Brahmbhatt, N. Ahmed, I. P. Singh, K. K. Bhutani. (2009).  Aromatization and chemoselective alkylation of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and its derivatives.  Tetrahedron Lett. 2009, 50, 5501–5504.https://doi.org/10.1016/j.tetlet.2009.07.075

S. B. Bharate, S. I. Khan, Nafees. A. M. Y, S. K. Chauthe, M. R. Jacob, B. L. Tekwani, I. A. Khan, I. P. Singh (2007).  Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.  Bioorg. Med. Chem. 2007, 15, 87–96. https://doi.org/10.1016/j.bmc.2006.10.006

Conference Proceedings (Refereed Only)

Influence of Freeze-thaw Cycles on Protein Integrity and Quality of Chicken Mea. Nafees Ahmed*,  Nur  Izyani Kamaruzman,  Saralla Nathan, Mohd. Ezharul  Hoque Chowdhury, Anuar Zaini Md Zain, Iekhsan Othman, Sharifah Binti Syed Hassan. International Conference on Halal Research 26-27 October, 2015, Istanbul, Turkey.

“Synthesis,biological activity and molecular docking studies of tricyclic guanidine derivatives for anti-malarial activity.” Nafees Ahmed, Shabana Khan, Kamles K Bhutani. 1st International Conference on Molecular Diagnostics & Biomarker Discovery, 23-25 October 2013 organized by INFORMM, USM,Penang (Best Oral Presentation Award).

“Design and synthesis of canthin-6-one amino acid conjugates for anti-HIV activity.” K. G. Brahmbhatt, V. M. Gohil, N. Ahmed, I. P. Singh, K. K. Bhutani. New Developments on Drug Discovery in Natural Products and Traditional Medicines II (DDNPTM) 20-24 November 2010, NIPER, Mohali, India.

“Synthesis of tricyclic guanidine analogues of batzelladine K for anti-HIV activity.” N. Ahmed, K. G. Brahmbhatt, I. P. Singh, K. K. Bhutani. New Developments on Drug Discovery in Natural Products and Traditional Medicines II (DDNPTM) 20-24 November 2010, NIPER, Mohali, India.

“Total synthesis of (±) Batzelladine K and its derivatives for anti-HIV activity.” N. Ahmed, K. G. Brahmbhatt, K. K. Bhutani. ESF-COST High-Level Research Conference on Natural Products Chemistry, Biology and Medicine III, Acquafredda di Maratea, Italy, 5-10 September 2010.

“Synthesis of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and 1-methyl-β-carboline-3-carboxylic acid derivatives for anti-HIV activity.” K. G. Brambhatt, N. Ahmed, K. K. Bhutani. Tenth Tetrahedron Symposium, 22-25 June 2010, Peking University, Beijing, China.

“Synthesis and Anti-HIV Activity of C-3 Dialkylated derivatives of Quinoline 2,4-diols.” N. Ahmed, K. G. Brahmbhatt, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Drug Discovery in Natural Products and Traditional Medicines (DDNPTM) Nov. 2008, NIPER, S.A.S. Nagar, Mohali, India.

“Design and synthesis of β-carboline derivatives for anti-HIV activity.” K. G. Brahmbhatt, N. Ahmed, S. Sabde, D. Mitra, I. P. Singh, K. K. Bhutani. Drug Discovery in Natural Products and Traditional Medicines (DDNPTM) Nov. 2008, NIPER, S.A.S. Nagar, Mohali, India.

Research Grants (Principle Investigator)

Nafees Ahemad, Chow Sek Chuen, Anton Dolzhenko, Iekhsan Othman, (2015-2018), Synthesis of 5-azapurine derivatives as new modulators of purinergic receptors, Ministry of Education Malaysia (FRGS), RM152,000.00

Nafees Ahemad, Ezharul Haque, Iekhsan Othman, Anuar Zaini, (2013-2015), Influence of chicken thawing process on protein integrity and activation of key cell signaling molecules in Halal vs Non-Halal meat, Ministry of Education Malaysia (FRGS), RM96,000.00

Research Grants (Co-Investigator)

Sharifah Binti Hussain Syed, Nafees Ahemad, (2014-2016), The role of carboxypeptidase B1, an Aedes aegypti midgut protein in DENV infection and replication via interaction with the viral envelope (E) protein, Ministry of Education Malaysia (FRGS), RM138,000.00

Ong Chin Eng, Nafees Ahemad, Uma Devi, Pan Yan, Malikarjuna, Yiap Beon, (2014-2016), Cytochrome P450 3A4 (CYP3A4) – probing mechanisms of genetic polymorphism by assessing enzyme kinetics, ligand binding and computational modeling for three common genetic variants CYP3A4*2, CYP3A4*3 and CYP3A4*17, Ministry of Education Malaysia (FRGS), RM142,000.00

Thet Thet Htar, Nafees Ahemad, Rakesh Naidu, Chua Lay Hong, (2015-2018), Identification of the pharmacophoric groups of an ideal GPER-1 ligand and its interaction mechanism with the receptor in breast cancer cells, Ministry of Education Malaysia (FRGS), RM 145, 000

Yap Wei Hsum, Nafees Ahemad, Lim Yang Mooi, Phelim Yong Voon Chen, (2015-2018), Evaluating the mechanism of maslinic acid in monocyte recruitment and foam cell macrophage formation: Regulatory effect of NF-κB and Nrf2, Ministry of Education Malaysia (FRGS), RM142,000.00

Shoaib Ali (PhD: 2017- present)
Project title: Design and synthesis of quinolone based compounds as anti-HIV agents
- Main Supervisor

Hammad Saleem (PhD: 2017- present)
Project title: Phytochemical investigation of plants to identify anti-cancer agents
- Main Supervisor

Shafiullah Khan (PhD: 2017- present)
Project title: Project title:Synthesis and evaluation of pharmacophore for GPER-1 ligands with anti-proliferative activity in breast cancer
- Co-Supervisor

Farah Rehan (PhD: 2017- present)
Project title: Formulation of casein nanomicells as novel drug delivery system for anti-cancer drugs
- Main Supervisor

Ooi Man Kwan (PhD: 2016 - present)
Project title: Identification of potential target antigen for the development of aptameric-based sensing diagnostic tools for chikungunya virus infection
- Co-Supervisor

Sultana Mehboba (Master: Completed - 2019)
Project title: Anti-Cancer drug delivery to breast cancer cells utilizing bio-degradable salt nanoparticles
- Co-Supervisor

Maeirah Afzal Ashaie (PhD: Completed - 2018)
Project title: Perturbation of cell-cell and cell-macromolecule interactions and their associated signalling cascades by biodegradable nanoparticle-assisted delivery of siRNA and study of consequential chemosensitization of breast cancer
- Co-Supervisor

Nabila Baby (PhD: Completed - 2018)
Project title: Breast cancer-targeted delivery of oncogene-specific siRNAs, tumor suppressor genes and classical anti-cancer drugs using inorganic nanoparticles
- Co-Supervisor

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