Dr. Tang Kim San

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Lecturer (Pharmacology)
School of Pharmacy

tang.kim.san@monash.edu
+603 5514 4958
Room  2-5-52

Dr. Tang obtained a Bachelor of Science degree in Biomedical Sciences from the Universiti Putra Malaysia and a Doctor of Philosophy from the Department of Pharmacology of the University of Alberta in Edmonton. He worked as a research fellow at the Division of Neurodegenerative Disorders of the St. Boniface General Hospital Research Centre in Winnipeg, Canada prior to joining the Monash University Malaysia in August 2009 as a lecturer. He has also received several national and international awards such as a scholarship award from the International Society of Neurochemistry, and the ‘Focus on Stroke’ Postdoctoral Fellowship Award from the Heart and Stroke Foundation of Canada. His research interest focuses on the mechanisms underlying the brain cell death in neurodegenerative diseases.

Qualifications

- Graduate Certificate in Higher Education (GCHE), Monash University, 2016

- Doctor of Philosophy, The University of Alberta, 2005

- Badhelor of Science, University Putra Malaysia, 1999

Expertise

1. Pharmacology

2. Cell physiology

Awards and Honours

Travel Award Education Excellence, Monash University Malaysia, 2018

Best Poster Award, The 6th Canadian Oxidative Stress Consortium, 2009

Scholarship Award for Excellence - International Society for Neurochemistry,  (2008)

Best Poster Award - Canadian Stroke Network, 2008

J Gordin Kaplan Graduate,  Student Award - FGSR, 2004

Research Interest

My current research interest mainly focuses on deciphering the mechanisms underlying the brain cell death in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and stroke. Previous studies have shown that oxidative stress plays a vital role in a common pathophysiology of neurodegenerative diseases. Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. Oxidative stress and excessive ROS production can cause homeostatic imbalance and lead to cellular dysfunction and eventual cell loss. The two classical cell death pathways are apoptosis and necrosis. Currently, there are many other contemporary pathways associated with cell death are being proposed. My laboratory employs pharmacological perturbation strategies in exploring the possible involvements of these cell death pathways in different disease models.

Scholarly Journals

Tang KS, Loo JMY, Tam CL and Lee SWH. Cultural influences on pharmacy student engagement in a global university. Pharmacy Education 2018; 18:110-118.

Tang KS. Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. Lipids in Health and Disease 2014; 13(1): 197-204

Tang KS. The potential therapeutic use of omega-3 fatty acids in Parkinson's disease. Archives of Pharmacy Practice 2012; 3(1): 121

Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA and Anderson CM. Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity. Glia 2010; 58(4): 446-457

Tang KS, Wang N, Tse A and Tse FW. Influence of quantal size and cAMP on the kinetics of quantal catecholamine release from rat chromaffin cells. Biophysical Journal 2007; 92: 2735-2746.

Xu J, Tang KS, Lu VB, Weerasinghe CP, Tse A and Tse FW. Maintenance of quantal size and immediately releasable granules in rat chromaffin cells by glucocorticoid. American Journal of Physiology - Cell Physiology 2005; 289: C1122-C1133.

Tang KS, Tse A and Tse FW. Differential regulation of multiple populations of granules in rat adrenal chromaffin cells by culture duration and cyclic AMP. Journal of Neurochemistry 2004; 92: 1126-1139.

Scholarly Journals (Refereed Only)

Tang KS. Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. Lipids in Health and Disease 2014; 13: 197-204.

Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA and Anderson CM. Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity. Glia 2010; 58(4): 446-457.

Tang KS, Wang N, Tse A and Tse FW. Influence of quantal size and cAMP on the kinetics of quantal catecholamine release from rat chromaffin cells. Biophysical Journal 2007; 92: 2735-2746.

Xu J, Tang KS, Lu VB, Weerasinghe CP, Tse A and Tse FW. Maintenance of quantal size and immediately releasable granules in rat chromaffin cells by glucocorticoid. American Journal of Physiology - Cell Physiology 2005; 289: C1122-C1133.

Tang KS, Tse A and Tse FW. Differential regulation of multiple populations of granules in rat adrenal chromaffin cells by culture duration and cyclic AMP. Journal of Neurochemistry 2004; 92: 1126-1139.

Research Grants (Principle Investigator)

Tang Kim San, (2018), The mechanisms of cell death in human SH-SY5Y cell line induced by zinc oxide nanoparticles, Tropical Medicine and Biology Platform, Monash University Malaysia

Tang KS, Teng WD, Rangabhatla P, Tan JS, (2012 - 2016), The role of metal oxide nanoparticles in Alzheimer's disease, (FRGS) The Ministry of Education, Malaysia, RM144,100.00

Research Grants (Co-Investigator)

Dolzhenko A, Othman I, Chow SC, Tang KS, (2014 - 2016), Heterocyclic purine analogues: xanthine oxidase substrates or inhibitors?  The Ministry of Education, Malaysia,  RM83,200.00

Velu S, Tang KS, (2012 - 2015), Synthesis and mechanistic study of oligostilbenoid-indole hybrids for potential antidiabetic lead compounds, The Ministry of Education, Malaysia, RM72,000.00

Postgraduate (MSc and PhD)

Tan Jey Sern (PhD: 2015-present)
Cellular mechanisms of neuroprotection. 
- Main Supervisor

Ooi Luyi (PhD: 2017-present)
Synthesis and bioactivity of multi-target-directed compounds for Alzheimer's disease
- Co-Supervisor

Honours Student

Che Win Ning (2018-present)
The protective potential of essential oils in Alzheimer’s disease model. 
- Co-Supervisor

Nurken Berdigaliyev (2017-2018)
Attenuation of amyloid beta (Aβ) induced  neuronal cell death by Heparin-binding EGF-like growth factor (HB-EGF). 
- Co-Supervisor

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