Dr. Tang Kim San

.

Lecturer
School of Pharmacy

tang.kim.san@monash.edu
+603 5514 4958
Room  2-5-52

Dr. Tang received his doctoral degree from the Department of Pharmacology, University of Alberta. He then spent several years working as a research fellow at the Division of Neurodegenerative Disorders of the St. Boniface General Hospital Research Centre in Canada prior to joining Monash University Malaysia as a lecturer. Dr. Tang has won several national and international awards, including a scholarship award from the International Society of Neurochemistry, and the ‘Focus on Stroke’ Postdoctoral Fellowship Award from the Heart and Stroke Foundation of Canada. His current research interest focuses on the mechanisms underlying the brain cell death in neurodegenerative diseases.

Qualifications

- PhD, The University of Alberta, 2005

- BSc, Universiti Putra Malaysia, 1999

- GCHE, Monash University, 2016

Expertise

1. Pharmacology

2. Neuroscience

3. Endocrinology

Teaching Commitment

Bachelor of Pharmacy: PHR1031, PHR1022, PHR2042

Research Interest

My current research interest mainly focuses on deciphering the mechanisms underlying brain cell death in neurodegenerative diseases. Previous studies have shown that oxidative stress plays a vital role in the pathophysiology of neurodegenerative diseases. Oxidative stress is induced by an imbalanced redox state, involving either the excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. Oxidative stress and excessive ROS production can cause homeostatic imbalance and lead to cellular dysfunction and eventual cell loss. The two classical cell death pathways are apoptosis and necrosis. Currently, there are many other contemporary pathways associated with cell death are being proposed. My laboratory employs pharmacological perturbation strategies in exploring the possible involvements of these cell death pathways in different disease models.

Scholarly Journals (Refereed Only)

2020

Tang KS. (2020) Protective effects of polydatin against dementia-related disorders. Current Neuropharmacology, Epub ahead of print. DOI: 10.2174/1570159X18666200611144825. (IMPACT FACTOR: 4.668, Web of Science)

Tang KS. (2020) Antioxidant and anti-inflammatory properties of yttrium oxide nanoparticles: new insights into alleviating diabetes. Current Diabetes Reviews, Epub ahead of print. DOI: 10.2174/1573399816999201012201111. (CiteScore: 4.0, Scopus)

Tang KS and Tan JS. (2020) The influences of aqueous dispersion media on the cytotoxic effect of zinc oxide nanoparticles. International Journal of Nanoscience 19(5), 2050001. DOI: 10.1142/S0219581X20500015. (CiteScore: 0.8, Scopus)

Tang KS. (2020) The potential role of nanoyttria in alleviating oxidative stress biomarkers: Implications for Alzheimer's disease therapy. Life Sciences 259, 118287. DOI: 10.1016/j.lfs.2020.118287. (IMPACT FACTOR: 3.647, Web of Science)

2019

Tang KS. (2019) The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus. Life Sciences 239, 117011. DOI: 10.1016/j.lfs.2019.117011.  (IMPACT FACTOR: 3.647, Web of Science)

Tang KS. (2019) The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers. Life Sciences 233, 116695. DOI: 10.1016/j.lfs.2019.116695. (IMPACT FACTOR: 3.647, Web of Science)

Tang KS and Tan JS. (2019) The protective mechanisms of polydatin in cerebral ischemia. European Journal of Pharmacology 842, 133-138. DOI: 10.1016/j.ejphar.2018.10.039. (IMPACT FACTOR: 3.263, Web of Science)

2018

Tang KS, Loo JMY, Tam CL and Lee SWH. (2018) Cultural influences on pharmacy student engagement in a global university. Pharmacy Education 18(1), 110-118. (CiteScore: 0.4, Scopus)

2014

Tang KS. (2014) Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. Lipids in Health and Disease 13, 197-204. DOI: 10.1186/1476-511X-13-197. (IMPACT FACTOR: 2.906, Web of Science)

2010

Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA and Anderson CM. (2010) Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity. Glia 58(4), 446-457. DOI: 10.1002/glia.20936. (IMPACT FACTOR: 5.984, Web of Science)

2007

Tang KS, Wang N, Tse A and Tse FW. (2007) Influence of quantal size and cAMP on the kinetics of quantal catecholamine release from rat chromaffin cells. Biophysical Journal 92(8), 2735-2746. DOI: 10.1529/biophysj.106.088997. (IMPACT FACTOR: 3.854, Web of Science)

2005

*Xu J, *Tang KS, Lu VB, Weerasinghe CP, Tse A and Tse FW. (2005) Maintenance of quantal size and immediately releasable granules in rat chromaffin cells by glucocorticoid. American Journal of Physiology-Cell Physiology 289(5), C1122-C1133. DOI: 10.1152/ajpcell.00514.2004. *equal contribution. (IMPACT FACTOR: 3.485, Web of Science)

2004

Tang KS, Tse A and Tse FW. (2004) Differential regulation of multiple populations of granules in rat adrenal chromaffin cells by culture duration and cyclic AMP. Journal of Neurochemistry 92(5), 1126-1139. DOI: 10.1111/j.1471-4159.2004.02944.x. (IMPACT FACTOR: 4.066, Web of Science)

Research Grants (Principle Investigator)

2020 - 2023: Tang, KS; Ng, KY; Othman, I; Teng, WD. Mechanistic studies on the cytoprotective potential of yttrium oxide nanoparticles against 6-hydroxydopamine-induced cellular model of Parkinson’s disease. FRGS, Ministry of Higher Education, Malaysia, (RM 167,070)

2019 - 2020: Tang, KS; Othman, I. The impact of zinc oxide nanoparticles on human health. TMB, Monash University Malaysia, (RM 5,000)

2018 - 2019: Tang, KS; Othman, I; Tan, J.S. The mechanisms of cell death in human SH-SY5Y cell line induced by zinc oxide nanoparticles. TMB, Monash University Malaysia, (RM 5,000)

2012 - 2016: Tang, KS; Rashid, SA; Ho, KL; Teng, WD. The role of metal oxide nanoparticles in Alzheimer’s disease. FRGS, Ministry of Higher Education, Malaysia, (RM 144,100)

2010 - 2011: Tang, KS. The role of fatty acids in neurodegeneration. Monash University Malaysia, (RM 30,000)

Postgraduate

RASHEED, Hina (2020 - present)
- Main Supervisor

SEE, Wesley Zhi Chung (2020 - present)
- Associate supervisor

OOI, Luyi (2017 - present)
- Associate supervisor

TAN, Jey Sern (Completed: 2019)
Zinc oxide nanoparticles induce necrotic-like cell death and energy depletion on SH-SY5Y cells
- Main Supervisor

Undergraduate

CHIN, Kar Wei (2020 - present)
- Co-supervisor

CHEN, Win Ning (Completed: 2019)
The potential of essential oils in Alzheimer's disease
- Co-supervisor

BERDIGALIYEV, Nurken (Completed: 2018)
Attenuation of amyloid beta (Aβ) induced  neuronal cell death by Heparin-binding EGF-like growth factor (HB-EGF)
- Co-supervisor

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