Dr. Chong Chun Wie

.

Senior Lecturer
School of Pharmacy

Chong.ChunWie@monash.edu
+603 5514 6188
Room  2-5-31

Dr Chong Chun Wie obtained his BSc (HONS) Biochemistry, and PhD (Molecular Microbiology) from University of Malaya. After his PhD, he worked briefly at National Antarctic Research Centre, University of Malaya briefly as a Post-Doctoral Research Fellow. He joined School of Pharmacy, IMU in 2012. During his tenure, he was appointed as the Programme Director of MSc Molecular Medicine and Head, Centre of Translational Research.  After 7 years with IMU, Dr Chong joined School of Pharmacy, Monash University Malaysia in July 2019. His main research focus is on the microbial ecology of soil and gastrointestinal systems. He is experienced in processing large 16S dataset and conducting multivariate data analyses including hypothesis testing, ordinations and modelling.

Qualifications

- Doctor of Philosophy in Microbial Ecology, University of Malaya, 2011

- Bachelor of Science in Biochemistry (Hons),  University of Malaya, 2005

Expertise

- Microbial Ecology in gut and soil systems

- 16S data processing and interpretation

- Multivariate statistical analysis and machine learning

- Epidemiology and antibiotics resistance

Employment History

July 2019 - Current - Senior Lecturer, School of Pharmacy, Monash University Malaysia

Aug 2018 - June 2019 - Senior Lecturer, School of Pharmacy, IMU

Feb 2018 - June 2019 - Head, Centre for Translational Research, IMU

Mac 2016 - Feb 2019 - Programme Director, MSc Molecular Medicine, IMU

Aug 2012 - July 2018 - Lecturer, School of Pharmacy, IMU

Feb 2012 - July 2012 - Post Doctoral Research Fellow, University of Malaya

Awards and Honours

2012

  • Sultan Mizan Antarctic Research Followship

2010 - 2011

  • UM Brightspark Fellowship, University of Malaya

Dr Chong Chun Wie started his research career on the Polar soil bacterial community and their responses to the climate, environments and anthropogenic impact. Due to the nature of  the research, he has gathered extensive experience in conducting field study in environmentally challenging ecosystems. The knowledge and understanding of microbial ecology were further transferred to the study of human and animal's gut systems. For instance, he has been involved in the study of gut microbial composition of farm animal, term/preterm neonate, oral cancer, parkinson disease and etc.

Dr Chong Chun Wie is currently interested to study the effect of drug and diseases to human gut microbiome as well as other systemic responses (e.g. metabonome, transcriptome, immune markers) using techniques such as interomics integration, time series analysis and multivariate modelling. In addition, he is also interested to explore the use of small molecules for targeted microbial modulation, and disease predictive/diagnosis model based on microbial composition.

Scholarly Journals (Refereed Only)

2019

Toh, Y. S., Yeoh, S. L., Yap, I. K. S., The, C. S. J., Win, T. T., Thong, K. L., Chong, C. W. (2019) Role of coaggregation in the pathogenicity and prolonged colonisation of Vibrio cholerae. Medical Microbiology and Immunology In press

Mahizan, N. A., Yang, S-K., Moo, C-L., Song, A. A. L., Chong, C-M., Chong, C. W., Abushelaibi, A., Lim, E. S-H., Lai, S. K. (2019) Terpene Derivatives as a Potential Agent against Antimicrobial Resistant (AMR) Pathogens. Molecules In press

2018

Tan, Y. F., C. Y. Lim, C. W. Chong, P. K. C. Lim, I. K. S. Yap, P. P. Leong and K. Voon (2018) Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal Orang asli Village in Peninsular Malaysia. Intervirology 61:92–95

Low, Y. M., Chong, C.W., Yap, I. K. S., Chai, L. C., Clarke, S. C., Ponnampalavanar, S., Abdul Jabar, K., Md Yusof, M. Y., The, C. S. J (2018) Elucidating the survival and response of carbapenem resistant Klebsiella pneumoniae after exposure to imipenem at sub-lethal concentrations. Pathogens and Global Health 112: 378-386.

Tan, S.C., Chong, C. W., Teh, C. S. J., Ooi, P. T., Thong, K. L. (2018) Occurrence of virulent multidrug-resistant Enterococcus faecalis and Enterococcus faecium in the pigs, farmers and farm environments in Malaysia. PeerJ 6:e5353

Chong, C. W., Silvaraj, S., Supramaniam, Y., Snape, I., Tan, I. K. P. (2018) Effect of temperature on bacterial community in petroleum hydrocarbon-contaminated and uncontaminated Antarctic soil. Polar Biology 41: 1763-1775

Tang, H.C., Sieo, C. C., Abdullah, N., Mohamad, R., Omar, A. R., Chong, C. W.,  Fitrianto, A., Ho, Y. W. (2018) Production of Phytase by Mitsuokella jalaludinii in Semi-Solid State Fermentation of Agricultural by-products. Sains Malaysiana 47: 277-286

Tan, A. H., Chong, C. W., Song, S. L., Teh, C. S. J., Yap, I. K. S., Loke, M. F., Tan, Y. Q., Yong, H. S., Mahadeva, S., Lang, A. E., Lim, S-Y. (2018) Altered gut microbiome and metabolome in patients with multiple system atrophy. Movement Disorders  33:174-176.

2017

Subramaniam, P., Abdul Jabar, K., Kee, B. P., Chong, C. W., Nathan, A. M., de Bruyne, J., Thavagnanam, S., Chua, K. H., Md Yusof, M-Y., Teh, C. S. J. (2017) Serotypes and Penicillin Susceptibility of Streptococcus pneumoniae Isolated from Children Admitted to a Tertiary Teaching Hospital in Malaysia. Indian Journal of Medical Research 148:225

Low, Y. M., Yap, I.K.S., Abdul Jabar, K., Md Yusof, M. Y., Chong, C. W., Teh, C.S.J. (2017) Genotypic and metabolic approaches towards the segregation of Klebsiella pneumoniae strains producing different antibiotic resistant enzymes. Metabolomics 13: 65.

Low, Y. M, Yap. P. S. X., Abdul Jabar, K., Ponnampalavanar, S., Karunakaran, R., Velayuthan, R., Chong, C.W., Abu Bakar, S., Md Yusof, M. Y., Teh. C. S. J. (2017) The Emergence of Carbapenem Resistant Klebsiella Pneumoniae in Malaysia: Correlation between Microbiological Trends with Host Characteristics and Clinical Factors. Antimicrobial Resistance & Infection Control 6: 5.

Tricarico, S., McNeil, H.C., Cleary, D. W., Head, M. G., Lim, V., Yap, I. Y. K., Chong, C. W., Tan, C. S., Nor Norazmi, M., Aziah, I.,  Cheah, E. S. G., Faust, S. N., Jefferies, J.M.C., Roderick, P.J., Moore, M., Ho, M. Y., Newell, M., McGrath, N., Doncaster, C. P., Kraaijeveld, A.R.,  Webb, J.S.,  Clarke, S.C. (2017) Pneumococcal conjugate vaccine implementation in middle-income Countries. Pneumonia 9: 6.

2016

Yap, P. S. X., Ahmad Kamar, A., Chong, C. W., Yap, I.K.S., Thong, K. L., Choo, Y.M., Md Yusof, M. Y., The, C.S.J. (2016) Intestinal Carriage of Multidrug-resistant Gram-negative bacteria in preterm-infants during hospitalization in Neonatal Intensive Care Unit (NICU). Pathogens and Global Health 110: 238-246.

Supramaniam, Y., Chong, C. W., Silvaraj, S. and Tan, I. K.-P. (2016). Effect of short term variation in temperature and water content on the bacterial community in a tropical soil. Applied Soil Ecology, 10, 279-289.

Chin, Y. T., Lim, Y. A. L., Chong, C. W., Teh, C. S. J., Yap, I. K. S., Lee, S. C., Tee, M. Z., Siow, V. W. Y. and Chua, K. H. (2016). Prevalence and risk factors of intestinal parasitism among two indigenous sub-ethnic groups in Peninsular Malaysia. Infectious Diseases of Poverty, 5, 1-15.

Kho, M. T., Chong, C. W., Lim, E. S. H., Ismail, N. H., Draper, L. O., Yam, W. K., Lim, P. K. C., Mak, J. W. and Yap, I. K. S. (2016). Systems biology analyses of the dynamic host response to Toxoplasma gondii infection in a murine model. Parasitology Open, 2: e9.

Zulkefli N. J., Mariappan V., Vellasamy K. M., Chong C. W., Thong K. L., Ponnampalavanar S., Vadivelu, J., Teh C. S. J. (2016). Molecular evidence of Burkholderia pseudomallei genotypes based on geographical distribution. PeerJ, 4: e1802.

2015

Chong C.W., Pearce, D.A., Convey, P (2015) Emerging spatial patterns in Antarctic prokaryotes. Frontiers in Microbiology 6: 1058.

Chong, C.W., Ahmad, A.F., Lim, Y.A.L., The, C.S.J., Yap, I.K.S., Lee, S.C., Chin, Y.T., Chua, K.H (2015) Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia. Scientific reports 5: 13338.

Lim, P.K.C., Yamasaki, H., Mak, J.W., Wong, S.F.., Chong, C.W., Yap, I.K.S., Ambu, S., Kumarasamy, V (2015) Field evaluation of a rapid diagnostic test to detect antibodies in human toxocariasis. Acta Tropica, 148: 32-37.

Shaufi M.A.M., Sieo C.C., Chong C.W., Gan H.M., Ho Y.W (2015) Deciphering chickens gut microbial dynamics based on high-throughput 16S rRNA metagenomics analyses. BMC Gut Pathogen 7: 4.

Yap I.Y.K., Kho M.T., Lim S.H.E., Ismail N.H., Yam W.K., Chong C.W. (2015) Acclimatisation-induced stress influenced host metabolic and gut microbial composition change. Molecular BioSystems 11: 297-306.

2013

Chong C.W., Goh Y.S., Convey P., Pearce D. A., Tan I. K. P (2013) Antarctic biogeography: What can we learn from bacterial isolates. Extremophiles, 17: 733-735.

2012

Chong C.W., Pearce D. A., Convey P., Yew, W. C., Tan I. K. P (2012c) Patterns in the distribution of soil bacterial 16S rRNA gene sequences from different regions of Antarctica. Geoderma 181-182: 45-55

Chong C.W., Pearce D. A., Convey P., Tan I. K. P (2012b) The identification of Key environmental parameters which could influence soil bacterial community compositionies on the Antarctic peninsula – a statistical approach. Antarctic  Science  24: 249–258

Chong C.W., Convey P., Pearce D. A., Tan I. K. P (2012a) Assessment of soil bacterial communities on Alexander Island (in the maritime and continental Antarctic transitional zone). Polar Biology 35: 387-399

2010

Chong C.W., Pearce D. A., Convey P., Tan G. Y. A., Wong R. C. S., Tan I. K. P (2010) High levels of spatial heterogeneity in the biodiversity of soil prokaryotes on Signy Island,Antarctica. Soil Biology & Biochemistry 42: 601-610

2009

Chong C. W., Tan  G. Y., Wong R. C. S. Riddle M. J., Tan I. K. P (2009) DGGE fingerprinting of bacteria in soils from eight ecologically different sites around Casey Station, Antarctica. Polar Biology 32:853–860

Chong C. W., Dunn M. J., Convey P., Tan G. Y. A., Wong R. C. S., Tan I. K. P (2009) Environmental influences on bacterial diversity of soils on Signy Island, Maritime Antarctic. Polar Biology 32:1571-1582

Research Grants (Present)

Type of Grant: Fundamental Research Grant Scheme
Title of Research: Carriage rate of upper respiratory tract pathobionts and their association with host metabolomics profiles and gut microbial composition in diabetic patients
Main Investigator: Prof Victor Lim
Co-Investigator: Dr Chong Chun Wie, A/P Stuart Clarke, Dr David Cleary, Dr Ivan Yap, Dr Cindy Teh
Date/Duration: 2019-2020
Amount: RM 168,332


Type of Grant: YPASM Research Grant
Title of Research: Molecular Evaluation of Biogeography and Functional Redundancy Theory in Antarctic Rhizosphere Prokaryotic Communities
Main Investigator: Dr Mai Chun Wai
Co-Investigator: Dr Chong Chun Wie, Prof Peter Convey, Dr Nicole Trefault, Prof David Pearce, Dr Cindy Teh, Dr Ivan Yap
Date/Duration: 2019-2021
Amount: RM 150,000


Type of Grant: Fundamental Research Grant Scheme
Title of Research: Understanding the impact of gut microbiome and metabolome in Parkinson’s disease
Main Investigator: Dr Tan Ai Huey
Co-Investigator: Dr Chong Chun Wie, Prof Lim Sheng Yang, Dr Cindy Teh, Prof Sanjiv K. Mahadeva
Date/Duration: 2019-2021
Amount: RM 123,200


Type of Grant: Fundamental Research Grant Scheme
Title of Research: Modulation of human immune responses by cohabitation of intestinal helminths and gut bacteria
Main Investigator: Prof Yvonne Lim Ai Lian
Co-Investigator: Dr Chong Chun Wie, Dr Reena Rajasuriar, Dr Lee Soo Ching
Date/Duration: 2017-2020
Amount: RM 147,920

Research Grants (Completed)

Type of Grant: CLMV grant
Title of Research: Establishing the regional Genomic and Phenomic database for carbapenemase-producing Klebsiella pneumoniae isolates for research and clinical impact
Main Investigator: Dr Cindy Teh Shuan Ju
Co-Investigator: Dr Chong Chun Wie, Dr Kartini Abdul Jabar, Dr Eugene Ong Boon Beng
Date/Duration: 2016-2017
Amount: RM 70,000


Type of Grant: Fundamental Research Grant Scheme
Title of Research: System biology comparison between mice with single and co-infection from Toxoplasma gondii and/or Trypanosoma evansi
Main Investigator: Dr Wong Shew Tung
Co-Investigator: Dr Chong Chun Wie, Prof Patricia Lim, Prof Nor Hadiani Ismail, Dr Mai Chun Wai
Date/Duration: 2015-2018
Amount: RM 162,000.00


Type of Grant: International Society of Infetious Diseases Research Grant
Title of Research: Longitudinal study of the impact of changing trends in genotypes and phenotypes of carbapenem-resistant Klebsiella pneumoniae infection in a Tertiary Teaching hospital in Malaysia
Main Investigator: Dr Cindy Teh
Co-Investigator: Dr Chong Chun Wie, Dr Rina Karunakaran, Prof Sasheela Sri Ponnampalavanar
Date/Duration: 2015-2016
Amount: USD 7000


Type of Grant: MOSTI Flagship
Title of Research: Biomarkers of polar and lower latitudes microbes in relation to heavy metal stress
Main Investigator: Prof Chu Wan Loy
Co-Investigator: Dr Chong Chun Wie, Dr Wong Chiew Yen, Dr Kok Yih Yih, Prof Peter Convey, Prof David Pearce, Dr Kenny Voon, Dr Chan Kok Keong
Date/Duration: 2015-2018
Amount: RM 819,902


Type of Grant: Fundamental Research Grant Scheme
Title of Research: Effect of coaggregation to the pathogenicity of Vibrio cholerae
Main Investigator: Dr Chong Chun Wie
Co-Investigator: Prof Leong Chee Onn, Prof Thong Kwai Lin, Dr Ivan Yap, Dr Cindy Teh
Date/Duration: 2014-2016
Amount: RM 145,400


Type of Grant: Fundamental Research Grant Scheme
Title of Research: Crosstalk between gene expression and metabolism revealing the dynamics of microbial response to antibiotics
Main Investigator: Dr Cindy Teh
Co-Investigator: Dr Chong Chun Wie, A/P Mohd Yasim Bin Md Yusof, Dr Chai Lay Chin, A/P Stuart Clarke, Dr Ivan Yap
Date/Duration: 2014-2016
Amount: RM 136,850


Type of Grant: Malaysia Toray Science Foundation
Title of Research: Does the variation in biofilms’ microbial diversity affects the integration and detachment of Vibrio cholerae in natural environments?
Main Investigator: Dr Chong Chun Wie
Co-Investigator: Prof Thong Kwai Lin, Dr Cindy Teh
Date/Duration: 2012-2014
Amount: RM 25,000


Type of Grant: Malaysia Toray Science Foundation
Title of Research: Does the variation in biofilms’ microbial diversity affects the integration and detachment of Vibrio cholerae in natural environments?
Main Investigator: Dr Chong Chun Wie
Co-Investigator: Prof Thong Kwai Lin, Dr Cindy Teh
Date/Duration: 2012-2014
Amount: RM 25,000

Postgraduate (MSc and PhD)

Kho Mee Teck (PhD: On-going)
System Biology Comparison Between Mice with Single and Co-infection from Toxoplasma gondii and/or Tryapanosoma brucei brucei
- Co-supervisor

Toh Yien Shin (PhD: On-going)
Effect of Osmolytes on Horizontal Plasmid Transfer in Extended Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae
- Co-supervisor

Mohd Shaufi Bin Mohd Asrore (PhD: Completed - 2017)
Impact of Escherichia coli Phages as an Adjunct to Probiotics in Modifying Chicken Gut Microbiota
- Co-supervisor

Helen Tang Hooi Chia (PhD: Completed - 2017)
Production of Phytase by Mitsoukella jalaludinii for Dietary Enzyme Supplement in Poultry
- Co-supervisor

Hong Wie Sze (MSc: On-going)
Distribution of Soil Heavy Metals Across Ecologically Distinct Habitats on Signy Island, Maritime Antarctica and Its Association With Bacterial Community Composition and Metabolic Profiles
- Main Supervisor

Noor Zaitulakma Binti Md Zain (MSc: On-going)
One Year Clinical and Molecular Surveillance of Staphyloccocus aureus at Two Tertiary Hospitals in Klang Valley
- Co-supervisor

Goh Mun Hon (MSc: On-going)
Metabolomics of Suspected Coronary Angiogram undergoing Elective Coronary Angiogram in National Heart Institute (IJN)
- Main supervisor

Norafifah Binti Musa (MSc: On-going)
Expression of monocytes chemoattractant protein-2 (MCP-2) as predictor for severity of dengue infection
- Main supervisor

Nurhairulamri Bin Kosnan (MSc: On-going)
The Metabolomics and Metagenomics Profiling of Leptospirosis in the identification of Early Diagnostics and Prognostic Markers
- Co-supervisor

Jocelyn Toh Yien Shin (MSc: Completed - 2018)
Effect of Coaggregation to the Pathogenicity of Vibrio cholerae
- Co-supervisor

Chin Yuee Teng (MSc: Completed - 2018)
Assessment of gut microbiome to parasitic infections among indigenious communities in Malaysia
- Co-supervisor

Yasoga Rangasamy (MSc: Completed - 2017)
Effects of Temperature and Water Concentration Bacterial Community Composition in Tropical and Antarctic Soil, Based on Microcosm Studies in the Laboratory
- Co-supervisor

Premmala A/P Rangasamy (MSc: Completed - 2016)
Application of Functional Metagenomics for Isolation and Screening of Antimicrobial Activitiy of Antarctic Soil Microorganism
- Co-supervisor

Reviewer

Polar Biology, Polar Science, Polar Research and Antonie Van Leeuwenhoek Journal of Microbiology, The journal of Microbiology, Soil Science, Journal of Environmental Science, Journal of Theoretical Biology, Frontiers in Microbiology, Frontiers in Medicine

Invited Speaker

Invited Trainer: “Building a Successful Research Career: Workshop 2: Experimental Design & Statistics”, IMU, Kuala Lumpur, 25 June 2019

Invited Speaker: ‘Metagenomics:  Magnifying the microbial world’, Faculty of Medicine, University of Malaya, Kuala Lumpur, 13-15 March 2017

Invited Trainer: “NMR-based Metabolomics workshop”, UiTM, Puncak Alam, 3-4 Nov 2016

Invited Speaker: “Statistical Approaches For Integrative Omics Data Analysis”, IMU, Kuala Lumpur, 2-3 September 2015

Antarctic Research

Chair, Workshop on Microbial Resillience, State of the Antarctic Ecosystem (AntECO)  sponsored event, UPM, 20 June 2019

Scientific Session Convener: Scientific Committee of Antarctic Research (SCAR) Open Science Conference, Kuala Lumpur Convention Center, Kuala Lumpur, 23-26 August 2016

SCAR Side Meeting Organiser: “Harmonising Molecular and Functional Analyses of Antarctic Microbiomes: Toward A Framework for Understanding Ecosystem Functional Resilience”, Sheraton Imperial Hotel, Kuala Lumpur, 27 August 2016