Dr. Khaw Kooi Yeong

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Lecturer 
School of Pharmacy

Khaw.KooiYeong@monash.edu
+603 5514 6135
Room  2-5-32

Dr Khaw Kooi-Yeong joined School of Pharmacy, Monash Malaysia as Assistant Lecturer in 2019. He obtained his PhD from School of Pharmacy, The University of Queensland. His PhD research focused on the discovery of chemotherapy molecules from natural product for skin cancer. Kooi-Yeong research interests are drug discovery, supercritical carbon dioxide extraction and secondary metabolite profiling of indigenous plants by LC-MS. His long-term career goal is to discover a cost-effective and efficacy drug to improve quality of life of human beings.

Qualifications

- Doctor of Philosophy, The University of Queensland, 2019

- Master of Science, University Sains Malaysia, 2013

Research Experience and Employment History

2014 - 2015 - Research Officer - Centre for Herbal Standardization, University Sains Malaysia

Awards and Honours

2015 - 2018

  • Australian Government Research Training Program scholarship

2017

  • Candidature development award, The University of Queensland

2011 - 2012

  • MyBrain 15, Ministry of Higher Education of Malaysia
Pharmaceutical Biodiscovery

The primary research interest of our laboratory is focusses on Pharmaceutical biodiscovery. We are interest to discover and harnessing the potential of natural molecules as the next generation drug candidate for neurodegenerative diseases (Alzheimer disease) and cancer.

The laboratory uses various techniques such as extraction, fractionation, semi-synthesis, enzymatic, and molecular biology to identify and characterise the novel compounds. Potent compounds will be carried forward to evaluate for their mechanisms of action in-vivo with our local and international collaborators.

Green Chemistry

The used of a sustainable and green extraction method for natural products is required in the modern age to minimize environmental impact and ensure the safety of human beings. One of the ways is to reduce and replace the use of the toxic, flammable and corrosive solvents in the extraction processes. The use of solvent less system, supercritical fluids and ionic liquids have been advocated as an alternative method to replace the notoriously unfavourable organic solvents. Supercritical carbon dioxide extraction offers alternative means for extraction of natural products. It has been used to extract value added bioactive compounds such as α-tocopherol, hyperforin and carotenoids. Our laboratory is interested to optimise factors that potentially governed the extraction processes and extraction of novel molecules from the natural resources.

We are keen to work together with researchers from different fields. Prospective postgraduate students with or without funding are welcome to discuss your research interest and work together with us.

Scholarly Journals (Refereed Only)

2020

Keng Yoon Yeong, Kooi Yeong Khaw, Yukari Takahashi, Yukihiro Itoh, Vikneswaran Murugaiyah, Takayoshi Suzuki. Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor. Bioorganic Chemistry.

2019

Nelson Jeng-Yeou Chear, Agustine Nengsih Fauzi, Kooi-Yeong Khaw, Sy-Bing Choi, Nik Soriani Yaacob and Choon-Sheen Lai.. Free radical scavenging and cytotoxic properties of acylated and non-acylated kaempferol glycosides from Stenochlaena palustris: A perspective on their structure-activity relationships. Pharmaceutical Chemistry Journal.

Kooi-Yeong Khaw, Marie-Odile Parat, Paul Nicholas Shaw, James Robert Falconer. (2019). Factorial design-assisted optimization of supercritical carbon-dioxide extraction of Carica papaya leaf juice cytotoxic active principles. Nature Scientific reports.

2018

Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Melati Khairuddean, Wen-Nee Tan. (2018). Garcixanthone G, A selective butyrylcholinesterase inhibitor from the stem bark of Garcinia atroviridis. Natural product science 24(2):88.

2017

Kooi-Yeong Khaw, Marie-Odile Parat, Nick Shaw, James R Falconer. (2017) Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules.

2016

Loiy Elsir Ahmed Hassan, Saad S, Dahham Samah M, Fadul Muhammad Ihtisham Umar, Aman Shah Abdul Majid, Kooi-Yeong Khaw, Amin Malik Shah Abdul Majid. (2016). Evaluation of in vitro and in vivo anti-inflammatory effects of (−)-pseudosemiglabrin, a major phytoconstituent isolated from Tephrosia apollinea (Delile) DC. Journal of Ethnopharmacology.

Wan Nurul Nazneem Wan Othman, Sook Yee Liew, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Khalijah Awang. (2016) Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).  Bioorganic and Medicinal chemistry.

Dileep Kumar Sukumarapillai, Kooi-Yeong Khaw, Yalda Kia, Vikneswaran Murugaiyah, Sathiyanarayanan Kulathu Iyer. (2016) Design, synthesis and cholinesterase inhibitory evaluation study of fluorescent N-benzylpiperidine-4-one derivatives. Medicinal Chemistry Research.

Nelson Jeng Yeou Chear, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Choon Sheen Lai. (2016) Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity. Journal of Food and Drug Analysis (IF=2.85)

2015

Sook Yee Liew*, Kooi-Yeong, Khaw*, Vikneswaran Murugaiyah, Chung Yeng Looi, Yi Li Wong, Mohd Rais Mustafa, Marc Litaudon, Khalijah Awang. (2015) Nature Indole Butyrylcholinesterase inhibitors from Nauclea Officinalis. Phytomedicine. (*equal contribution).

2014

Kooi-Yeong Khaw, Sy Bing Choi, Soo Choon Tan, Habibah Abdul Wahab, Kit Lam Chan, Vikneswaran Murugaiyah. (2014) Potent Cholinesterase inhibitors from Garcinia mangostana, Investigation on their inhibitions kinetic and molecular docking. Phytomedicine.

Nargis Jamila, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Amir Atlas Imran Khan, Naeem Khan, Sadiq Noor Khan, Melati Khairuddean, Hasnah Osman. (2014) Molecular docking studies and in vitro cholinesterase enzyme inhibitory activities of chemical constituents of Garcinia hombroniana. Natural product Research.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Venu Sanjeevi Lakshmipathi, Mohammad Hossein Ahmadi Azqhandi (2014). Synthesis of highly functionalized dispiropyrrolidine derivatives as novel acetylcholinesterase inhibitors. Letter in Drug Design and Discovery.

Tan Wen Nee, Melati Khairuddin, Kooi-Yeong Khaw, Vikeswaran Murugaiyah. (2014) New cholinesterase inhibitors from Garcinia atroviridis. Fitoterapia.

Nargis Jamila, Melati Khairuddin, Kooi-Yeong Khaw, Hasnah Osman, Vikneswaran Murugaiyah. (2014) Cholinesterase inhibitory triterpenoids from the bark of Garcinia hombroniana. Journal of Enzyme Inhibition and Medicinal Chemistry.

2013

Kia Yalda, Osman Hasnah, Kumar R S, Murugaiyah V, Basiri A, Kooi-Yeong Khaw, Rosli, M.M. (2013). An efficient ionic liquid mediated synthesis, cholinesterase inhibitory activity and molecular modeling study of novel piperidone embedded unsaturated ketones. Medicinal Chemistry.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Hasnah Osman, Vijay H. Masand. (2013) Synthesis, characterization and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors. Bioorganic Chemistry.

Yi Chen Chan, Abdussalam Salhin Mohamed Ali, Melati Khalrudeen, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Ali Basiri (2013). Synthesis and molecular modelling study of cu complexes derived from 2 (diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities. Chinese Chemical Letter.

Jamila Nargis, Khairuddean Melati, Choon-Sheen Lai, Osman Hasnah, Keng Chong Wong Murugaiyah Vikneswaran, Kooi-Yeong Khaw (2013). Antioxidant, anti-cholinesterase and antibacterial activities of the bark extracts of Garcinia hombroniana. African Journal of Pharmacy and Pharmacology.

Sultan Ayesh Mohammed Saghir, Amirin bin Sadikun, Kooi-Yeong Khaw, Vikneswaran Murugaiyah (2013). Star Fruit (Averrhoa carambola L.): from traditional uses to Pharmacological activities. Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants.

December 2019 - November 2020: Toxicity study of Carica papaya leaves. Industry grant, (RM 27 000).

September 2019 - September 2020: Deciphering the neurobiology of tropical plants as therapeutic compounds for chronic stress induced neurodegeneration. School of Pharmacy Seed grant, (RM 20 000).

June 2019 - June 2020: Evaluation of papaya leaf as potential nutraceutical for neurodegenerative disease. Tropical medicine and biology (TMB) platform grant, (RM 5,000).

June 2019 - June 2020: Biocompatible Ionic Liquids as Extraction media for Removal of Free Fatty Acids from Palm Oil.  Monash early career researcher grant, (RM 20,000).

June 2019 - June 2020: Design and Synthesis of Novel Benzimidazole Derivatives as Butyrylcholinesterase Inhibitor. Monash early career researcher grant, (RM 20,000).

2011 - 2012: Phytochemical and pharmacokinetic studies of chemical constituents of Garcinia mangostana, University Sains Malaysia, (RM 10,000).

Reviewer, 2019  

Medicina

Reviewer, 2018  

Biomedicine & Pharmacotherapy

Molecules

International Journal of Molecular Sciences

Reviewer, 2017

Natural Product Research

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