Dr. Ong Yong Sze
Ong obtained her undergraduate degree in Bachelor of Biomedical Science from Universiti Putra Malaysia (UPM) in 2013 and subsequently continued her higher qualification (PhD in Pharmacology) in the same university. During her PhD study, she was awarded with the SMARTLINK scholarship from ERASMUS MUNDUS for a research attachment at the Faculty of Pharmacy, Universidade do Porto, Portugal for a duration of 18 months. Prior to the completion of her PhD, she joined Monash University Malaysia as an assistant lecturer in the School of Pharmacy. Ong's research work focuses on the development of drug delivery system for the treatment of cancer, aiming to improve the medication safety and efficacy through the approach of nanotechnology.
- Doctor of Philosophy in Pharmacology, Universiti Putra Malaysia, 2019
- Bachelor of Biomedical Science, Universiti Putra Malaysia, 2013
Feb 2020 - Current: Lecturer, School of Pharmacy, Monash University Malaysia
March 2019 - Feb 2020: Assistant Lecturer, School of Pharmacy, Monash University Malaysia
Sept 2013 - Feb 2014: Research assistant, Institute of Bioscience, Universiti Putra Malaysia
Awards and Honours
- Travel grant for RADIOMAG training school, Institute for Nanoscience and Nanotechnology, Greece
- First runner-up in final competition of Three Minute Thesis (3MT), Universiti Putra Malaysia
- Erasmus Mundus Scholar Award (SMARTLINK project), European Union
Conventional drug delivery systems are often accompanied by systemic side effects that mainly attributed by their nonspecific bio-distribution and uncontrollable drug release characteristics. This raised my interest to develop a smart drug delivery system with specific targeting, controlled release and minimal toxicity to improve the therapeutic efficacy via the approach of nanotechnology. Apart from drug delivery system, the research team is also exploring the potential of nanoparticles in the application of hyperthermia and diagnostics for cancer.
My research interest also focuses on the safety and potential adverse effects of nanoparticles (nanotoxicity) and natural products in healthcare application.
Scholarly Journals (Refereed Only)
Barbosa, Ana Isabel; Fernandes, Sara R.; Machado, Sandia; Sousa, Patrícia; Sze, Ong Yong; Silva, Eduarda M.P. et al. (2019): Fast monolith-based chromatographic method for determination of methotrexate in drug delivery studies. In Microchemical Journal 148, pp. 185–189. DOI: 10.1016/j.microc.2019.04.075.
Alexander, Henna Roshini; Syed Alwi, Sharifah Sakinah; Yazan, Latifah Saiful; Zakarial Ansar, Fatin Hanani; Ong, Yong Sze (2019): Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models. In Evidence-based complementary and alternative medicine: eCAM 2019, p. 9725738. DOI: 10.1155/2019/9725738.
Haron, Aminah Suhaila; Syed Alwi, Sharifah Sakinah; Saiful Yazan, Latifah; Abd Razak, Rohaina; Ong, Yong Sze; Zakarial Ansar, Fatin Hannani; Roshini Alexander, Henna (2018): Cytotoxic Effect of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) on Liver Cancer Cell Integrated with Hepatitis B Genome, Hep3B. In Evidence-based complementary and alternative medicine: eCAM 2018, p. 1549805. DOI: 10.1155/2018/1549805.
Ong, Yong Sze; Saiful Yazan, Latifah; Ng, Wei Keat; Abdullah, Rasedee; Mustapha, Noordin M.; Sapuan, Sarah et al. (2018): Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice. In Nanomedicine (London, England) 13 (13), pp. 1567–1582. DOI: 10.2217/nnm-2017-0322.
Ong, Yong Sze; Saiful Yazan, Latifah; Ng, Wei Keat; Noordin, Mustapha M.; Sapuan, Sarah; Foo, Jhi Biau; Tor, Yin Sim (2016): Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice. In International journal of nanomedicine 11, pp. 5905–5915. DOI: 10.2147/IJN.S114205.
Rahman, Napsiah Abd; Yazan, Latifah Saiful; Wibowo, Agustono; Ahmat, Norizan; Foo, Jhi Biau; Tor, Yin Sim, Ong, Yong Sze et al. (2016): Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231. In BMC complementary and alternative medicine 16, p. 354. DOI: 10.1186/s12906-016-1328-1.
Saiful Yazan, Latifah; Muhamad Zali, Muhamad Firdaus Shyfiq; Mohd Ali, Razana; Zainal, Nurul Amira; Esa, Nurulaidah; Sapuan, Sarah et al. (2016): Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane. In BioMed research international 2016, p. 4036926. DOI: 10.1155/2016/4036926.
Yazan, Latifah Saiful; Ong, Yong Sze; Zaaba, Nur Elena; Ali, Razana Mohd; Foo, Jhi Biau; Tor, Yin Sim (2015): Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice. In Asian Pacific Journal of Tropical Biomedicine 5 (12), pp. 1018–1026. DOI: 10.1016/j.apjtb.2015.09.008.
2019 - 2020: Development of resveratrol co-loaded superparamagnetic iron oxide nanoparticle in nanostructured lipid carrier (RSV,SPION-NLC) for the treatment of breast cancer- a multimodal therapeutic regime, Global Asia in the 21st Century (GA21) Research Funding, (RM 9,800)
2019 - 2020: Deciphering the neurobiology of tropical plants as therapeutic compounds for chronic stress induced neurodegeneration, School of Pharmacy Seed grant, (RM 20 000)
2019 - 2020: Toxicity study of Carica papaya leaves, Industry grant, (RM 27 000)
Frontiers in Pharmacology
Editorial Board Member, Current
Progress in Microbes and Molecular Biology
Malaysian Association for Cancer Research (MACR)