Animal Research Platform
Monash University Malaysia's Animal Research Platform provides a scaffold for animal research through the supply of high-quality laboratory animals and the provision of essential amenities such as ABSL-2, SPF, and Transgenic Fish Facilities. We also provide technical resources, contract research services using RG 2 category infectious agents, and animal procedural training. This platform establishes the highest standard of management processes ensuring high standards of welfare and well-being of the animals specified in the relevant Codes of Practice to support national and international biomedical research.
MUMARP staff are experienced in animal breeding and providing animals for biomedical research studies, training, and educational purposes. We provide facility access to users such as the ABSL-2, SPF, Transgenic Fish and Fish Facilities to conduct various types of research such as infectious, therapeutics, neuroscience, behavioural, and fundamental studies.
Our animal behaviour analysis systems are used for motor coordination, learning and memory, social interaction, addiction, circadian rhythm, depression, and anxiety. In addition, users are also able to access imaging equipment (in conjunction with MUM Optical Imaging Platform) such as the microinjection system for drug treatment and creation of transgenic animals, and fluorescence microscopy for drug screening and observing cell activities. MUMARP also organises seminars and technical workshops related to animal research to bring users together from a wide range of research, providing a forum for collegial interaction and collaboration.
Key instrumentation
- Class II Biosafety Cabinet
- Individually ventilated cages (IVC)
- Rodent and zebrafish behaviour systems
- CO2 and isoflurane anaesthesia chambers
- Rat and rabbit metabolic cages
SPF Animal Facility
Equipment | Model Identification | Short Description of Capabilities | Quantity |
---|---|---|---|
Rodent behaviour system |
Rodent behaviour system can be used for several behaviour study in rodent models. Anxiety-like behaviour (Open field test, Light transition test), Depressive behaviour (Force swimming test), Circadian rhythm, Sleep disorder (activity sensor), Schizophrenia-like behaviour and Learning and memory (Object
placement test). The item consists: 1. Open field test (Lime light 2.7, Actimetrics Inc) 2. Forced swimming test (Macro Act 1.06, Neuroscience Inc) 3. Light-Dark transition test (MED-PC IV, Med Association Inc) 4. Prepulse inhibition test system (SR-LAB, San Diego Instruments) 5. Activity sensor system | 1 | |
1. Stereotaxic Instrument (SRS-6 HT, Narishige Inc) 2. Micro drill | Stereotaxic surgery system can be used for microinjections into the target site of the brain or other tissue to deliver drugs, viral vectors or cell transplant. | 1 |
TG Fish Facility
Equipment | Model Identification | Short Description of Capabilities | Quantity |
---|---|---|---|
Zebrafish behaviour system (MDE GmbH, Analysis software Komi 2.0 written by Pictron Kft) | This system can be used for several behaviour study in Zebrafish. In particular, locomotors activity, place preference, Anxiety-like behavior, Social interactive behavior Learning and memory | 1 | |
zebrafish microinjection system (FemtoJet express (Eppendorf) |
A microinjection system is to inject small volume of solution. Microinjection is performed under a microscope with the aid of a micromanipulator which allows for small movement under high magnification. We can deliver substances such as vector, dye, protein and DNA/RNA into cells, eggs and tissues
with this system. It is useful to create transgenic animals. | 1 |
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Location
Building 3, Level 8,
School of Medicine and Health Sciences,
Monash University Malaysia