PhD/MSc studentship (Dr Ngin Cin Khai) (1)
Project Title: Molecular biology of STA1 (Signal Transducer and Activator of Transcription1) and its possible role in viral pathogenesis- A host-virus relationship towards the anti-viral agent development.
Description of the project:
Most viral protein products fall into one of three categories: special enzymes needed for viral replication; inhibitory factors that stop host-cell DNA, RNA, and protein synthesis; and structural proteins used in the construction of new virions. Inflammation is a hallmark of many serious human infectious diseases caused by a wide variety of viruses and investigating molecular mechanisms of the inflammatory responses resulting viral infection is of great significance in controlling the appearance of complications and reducing the associated tissue damage.
The first line of defense against viral infections is interferons (IFNs), the widely expressed cytokines, which have potent antiviral and growth-inhibitory effects. The first signaling pathway shown to be activated by IFNs was the JAK–STAT pathway [Janus kinase (JAK). Signal Transducer and Activator of Transcription (STAT)]. We have newly discovered the molecular interaction between the nucleoprotein (NP) of influenza virus A and cellular STAT1. To further investigate mechanisms of pathogenesis of subsequent inflammatory responses and activation of transcription of related genes in the viral life cycle is an important step towards the development of the new anti-viral approaches.
Candidates should have a Bachelor degree in Science related discipline with 1st or 2nd upper class honours or equivalent.
For English requirements, please refer to these links:
Level of support
Scholarships will be awarded on a competitive basis. For further details, please refer to this link.
Application is on a first come first serve basis. Once a suitable candidate is found, the application will be closed.
Only eligible candidates should submit an application and resume directly to Dr. Ngin Cin Khai