PhD/MSc Studentship (Dr. Ngin Cin Khai) (2)
Project Title: Studies on attenuation of Influenza A virus endocytosis by HB-EGF (Heparin-binding EGF-like growth factor)
Description of the project:
Influenza A viruses (IAV) enter host cells by binding to sialic acid residues at the host cell surface. Moreover update of IAV into host cells is promoted by epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), and a member of the ErbB family of signaling receptors.
The EGFR is activated upon ligand binding and leads to internalisation of the receptor and degraded via lysosomes or recycled to the cell surface depending on the ligand bound. Endocytic down regulation of the EGFR is an important mechanism for signal attenuation. Removal of the EGFR from the cell surface can also be achieved by prolonged stimulation with EGF, causing ligand induced internalisation and degradation.
So far eight ligands for EGFR have been described and among them heparin-binding EGF-like growth factor (HB-EGF) is more potent inducers of EGFR activation then EGR and stimulation of EGFR by HB-EGF lead to a strong induction of internalisation and to degradation of a large portion of the internalised receptor.
Low cell surface EGFR leads to less viral endocytosis and subsequent reduction in viral replication inside the cells. This study is to develop the potential therapeutic protein to attenuate the viral attachment to the cell surface and minimise the influenza induced morbidity.
The position is available to Malaysians. Candidates should have a Bachelor degree in Science related discipline with 1st or 2nd upper class honours or equivalent.
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Level of support
Scholarship and Tuition Fee Waiver will be awarded on a competitive basis.
Application is on a first come first serve basis. Once a suitable candidate is found, the application will be closed.
Only eligible candidate should write in application and resume directly to Dr Ngin Cin Khai (email@example.com)