Anticancer Applications of Nanostructured Materials Functionalized with Metallodrugs

Abstract:

In anticancer chemotherapy, a wide variety of metallodrugs are being used in preclinical and clinical trials for the treatment of different tumors. However, most of them present various limitations for their use in humans that are usually associated to their intrinsic toxicity, low solubility in water, poor biodistribution and confusing pharmacokinetic behaviour.

In this context, many different approaches have been used for the administration of metal-based drugs attempting the enhancement of their therapeutic properties by local delivery using, vectors based on cyclodextrines, curcubit[n]uryls, human proteins, lipids, lipid nanocapsules, carbon nanotubes, metal nanoparticles, polymeric nanoparticles and ceramic materials, for example.

Thus, our group has studied the use of nanostructured porous silica-based materials with different pore size, particle size and morphology functionalized with metallodrugs or natural products observing different behaviour in biological tests. Preclinical trials in vitro carried out with these materials have shown very interesting properties in some cases acting as drug delivery systems and in other cases working as drug protectors.

This communication will be focused on our last investigations in this field in which we have recently reported systems which have been tested in vivo in mice with melanoma observing the abolishment of the tumor and cell differentiation to a non-invasive phenotype without toxicity to any of the vital organs.

Speaker’s Profile:

Professor Santiago Gómez-Ruiz is currently attached with the Department of Biology and Geology, Physics and Inorganic chemistry in Rey Juan Carlos University, Móstoles (Madrid), Spain. He has more than 10 years of experience in teaching and research collaborations with esteem universities located in Germany, Czech Republic, Greece, United Kingdom. United States, China, Japan, and India. To date, Professor Santiago has more than 100 co-authored research publications in high impact international journals, three book chapters and three complete books. He is also a recipient of prestigious awards such as the European young chemist award in 2010 as well as the supervisor winner of the research work in 2011. Apart from the above, Professor Santiago is also a prominent speaker in both national and international conferences.