Ligand Approach toward Chemical and Biological Science

Abstract:

As a highly visible government research organization, the Academia Sinica is always subject to public opinion of their research initiatives. Therefore, Academia Sinica will soon be under pressure by the Taiwan public to formulate a sound scientific policy to decrease the carbon footprint and the dependence on fossil fuel in the production of fine chemicals. Therefore, our lab has a vested interest in developing catalysis process in a greener and more sustainable manner, particularly towards CH activation and CO2 fixation. Furthermore, anti-cancer agents: Amino-NHC Gold Complexes was developed to have the capacity to induce apoptosis through a p53-bak pathway, a sensational finding that could serve as a new alternate strategy to reduce the resistance of cancer cells to p53-induced apoptosis. The anti-tumor pathway is uniquely different from classical drug cis-platin.

Speaker’s Profile:

Dr Tiow-Gan Ong obtained his PhD from the University of Kentucky, USA in 2000. Upon graduation, Dr Ong joined University of California at Santa Barbara in USA as a Postdoctoral Scientist before moving on to the University of Ottawa, Ontario, Canada, as a Postdoctoral Researcher in 2004. Dr Ong was a recipient of prestigious awards including the Outstanding Young Investigator award in 2010 (The Taiwan Chemical Society); the Outstanding Young Research Grant Award in 2012 (National Science Council); Distinguished Lectureship Award in Asian in 2013 (The chemical Society of Japan) and the Outstanding Young Scholar Award in 2014 (Shui-Mu Foundation of Chemistry, Taiwan).

Dr Ong is currently a Research Fellow/Professor in the Institute of Chemistry, Academia Sinica, Taipei, Taiwan. His current research interests include (a) functional linked nitrogen-heterocyclic carbene (NHC) and (b) carbodicarbenes, which were used to isolate uniquely chemical structures and to discover interestingly reactivities in transition metals and main group elements.