Cheow Yuen Lin

Senior Lecturer
School of Science

cheow.yuen.lin@monash.edu
+603 5514 4401
Room 4-8-38
https://orcid.org/0000-0002-0336-2328

Dr. Cheow Yuen Lin is currently a lecturer with the School of Science, Monash University Malaysia (MUM).  He obtained his BSc (Hons) in Chemistry and MSc in Natural Product Chemistry from University Putra Malaysia. After graduating, he taught Cambridge A-level Chemistry at Taylor’s College for three years.

He then undertook his PhD in Organometallic Chemistry at Nanyang Technological University Singapore. He is a trained synthetic chemist with skills in molecular synthesis, characterization, Schlenk-line techniques manipulating moisture and air sensitive compounds.  Following his doctorate, Dr Cheow spent a year lecturing at Singapore Polytechnic.

He is the author and co-author of twelve refereed articles. He is currently supervising and co-supervising eight PhD students. His students are working mainly on

1. Synthesis of metal carbene complexes and evaluation of their biological properties.

2. Isolation and characterisation of bioactive compounds from Malaysian tropical plants and bacteria obtained from tropical peat swamp forest soil.

Qualifications

  • Doctor of Philosophy in Organometallic Chemistry, Nanyang Technological University, Singapore, 2012
  • Master of Science in Natural Product Chemistry, Universiti Putra Malaysia, 2005
  • Bachelor of Science (Honours) in Chemistry, Universiti Putra Malaysia, 2002

Expertise

Natural Product Chemistry, Organometallic Chemistry, Asymmetric Synthesis of Chiral Heterobidentate Phosphine and Arsine Ligands, N-Heterocyclic Carbene (NHC) Ligands.

Research Interests

  • Synthesis of metal carbene complexes and evaluation of its biological properties.
  • Chemical isolation, structure elucidation and biological properties of natural products from Malaysian tropical plants

The research activities in my group revolve around drug discovery, design and development. My research is largely focused on natural product chemistry and bioorganometallic chemistry specifically discovering compounds as potential anticancer and antimicrobial agents. Our lab is isolating and characterising bioactive compounds from Malaysian tropical plants and bacteria obtained from tropical peat swamp forest soil. The ecosystem biodiversity in Malaysia is among the world richest and its potential as a vast pharmaceutical store bank has been cited by many scientists.  As a natural product chemist, I collaborate with my colleagues and discover a myriad of interesting chemistry and biology from our ecosystem. I also undertake scholarly activity to make organometallic complexes and evaluate their biological properties.

PhD Studentship

Application for a PhD position for a project with the following topic is available. This position will be in a full-time research mode.

Research topic:
“Silver N-heterocyclic carbene complexes as potential antibacterial and cytotoxic agents”

Requirement:
1. Malaysian with a relevant degree for admission into Monash University’s PhD program. At least a degree of BSc with First Class Honours or a degree of MSc in Chemistry/ Medicinal Chemistry/ Pharmacy/ Pharmaceutical Science.
2. A research studenship is available.
3. The project covers research areas in synthetic (in)organic chemistry and biological assay (antimicrobial and cell cytotoxicity).

To apply, send your Cover Letter and Resume to : Dr. Cheow (cheow.yuen.lin@monash.edu)
Any informal inquiries can be directed to the email as above.

Teaching

CHM1051 (Advanced Chemistry 1)

Scholarly Journals

Suerialoasan Navanesan, Norhanom Abdul Wahab, Sugumaran Manickam, Yuen Lin Cheow, Kae Shin Sim. Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells. Chemico-Biological Interactions, 2017, 273, 37-43. DOI: https://doi.org/10.1016/j.cbi.2017.05.022

Ong, Kuan Shiong, Cheow, Yuen Lin, Lee, Sui Mae. The role of reactive oxygen species in the antimicrobial activity of pyochelin. Journal of Advanced Research 2017, 8, 393-398. DOI: http://dx.doi/10.1016/j.jare.2017.05.007

Si Hui Chen, Si Ling Ng, Yuen Lin Cheow, Adeline Su Yien Ting. A novel study based on adaptive metal tolerance behavior in fungi and SEM-EDX analysis. Journal of Hazardous Materials. 2017,  334, 132–141. DOI:  http://doi.org/10.1016/j.jhazmat.2017.04.004

Biswas, Nirupam ; Cheow, Yuen Lin ; Tan, Chin Ping ; Kanagaratnam, Sivaruby; Siow, Lee Fong, Cocoa Butter Substitute (CBS) Produced from Palm Mid-fraction/Palm Kernel Oil/Palm Stearin for Confectionery Fillings , Journal of the American Oil Chemists Society, 2017,  94,  235-245.DOI: 10.1007/s11746-016-2940-4

Biswas, Nirupam ; Cheow, Yuen Lin ; Tan, Chin Ping ; Siow, Lee Fong Physical, rheological and sensorial properties, and bloom formation of dark chocolate made with cocoa butter substitute (CBS). LWT-Food Science and Technology. 2017,  82, 420-428. https://doi.org/10.1016/j.lwt.2017.04.039

Cheong, Siew Loon; Cheow, Yuen Lin; Ting, Adeline Su Yien , Characterizing antagonistic activities and host compatibility (via simple endophyte-calli test) of endophytes as biocontrol agents of Ganoderma boninense , Biological Control, 2017,  105, 86-92.DOI:10.1016/j.biocontrol.2016.12.002

Ong, Kuan Shion ;  Aw, Yoong Kit ; Lee, Learn Han ; Yule, Catherine M; Cheow, Yuen Lin; Lee, Sui Mae,  Burkholderia paludis sp nov., an Antibiotic-Siderophore Producing Novel Burkholderia cepacia Complex Species, Isolated from Malaysian Tropical Peat Swamp Soil , Frontiers in Microbiology, 2016, 7, 2046.DOI: 10.3389/fmicb.2016.02046

Yoong Kit Aw, Kuan Shion Ong, Catherine Mary Yule, Yuen Lin Cheow, Learn-Han Lee, Sui Mae Lee . Newly isolated Paenibacillus tyrfis sp. nov., from Malaysian tropical peat swamp soil with broad spectrum antimicrobial activity. Frontiers in Microbiology, 2016, 7(219), 1-9. doi: http://dx.doi.org/10.3389/fmicb.2016.00219

Yuen Lin Cheow, Sumod A. Pullarkat, Yongxin Li, Pak-Hing Leung . Asymmetric hydroarsination reactions toward synthesis of alcohol functionalised C-chiral As-P ligands promoted by chiral cyclometallated complexes. Journal of Organometallic Chemistry, 2012, 696, 4215-4220.

Sumod A. Pullarkat, Yuen Lin Cheow, Yongxin Li and Pak-Hing Leung .  Enantioselective, High-yielding Synthesis of Alcohol-Functionalised Diphosphanes Utilizing Asymettric Control with a Chiral Auxilliary. Eur. J. Inorg. Chem.,2009, 2375-2382.

Gwendoline Cheng Lian Ee, Yuen Lin Cheow . Secondary Metabolites from two Garcinia Species and their Biological Acitivities, Asian J. of Chem. 2008, Vol 20, 343-351.

G.C.L.Ee, A.S.M.Kua, Y.L Cheow, C.K.Lim, V. Jong and M. Rahmani. A new pyranoxanthone Inophyllin B from Calophyllum inophyllum (Guttiferae). Natural Product Sciences, 2004, 10(2), 220-222.

Research Grants

  • Cheow, Y.L, 2014-2016, Synthesis, Characterization and Evaluation of anti-cancer and anti-microbial activities of Chiral Nickel, Palladium and Platinum Pyridine-N-Heterocyclic Carbene Complexes, Ministry of Education, RM111k

PhD Students (Present)

  1. Choo Kar Bee (Main supervision) - Synthesis, characterisation and bioactivity evaluation of chiral metal pyridine-NHC compounds
  2. Mah Wee Li (Main supervision) - Synthesis and Evaluation of Antimicrobial activities of Silver and Copper N-Heterocyclic Carbene
  3. Yong Mei Mun (Co-supervision) - Chemical constituents and bioactivity of selected traditional medicinal plants
  4. Yaw Chong Wey (Co-supervision) - Electrochemical studies of antioxidant agents and their applications
  5. Wong Kak Ming (Co-supervision) - Characterisation of chemical constituent(s) from Hemisgraphis alternata and its wound healing and anti-inflammatory properties
  6. Carrie Sim Siew Fang (Co-supervision) - Evaluating the use of metal-tolerant endophytes for plant growth and disease control in metal-laden soils
  7. Chen Si Hui (Co-supervision) - Investigation on efficacy and mechanisms of metalophilic fungi for removal of dyes and heavy metals
  8. Krystle Santiago (Co-supervision) - Biological Activities and Chemical Constituents of the Fruticose Lichen Usnea and its Associated Endolichenic Fungi

PhD Students (Completed)

  1. Steven Aw Yoong Kit (Co-supervision) - Identification and characterisation of antimicrobial producing Paenibacillus sp
  2. Nirupam Biswas (co-supervision) - Development and Characterization of Cocoa Butter Alternatives from Palm-based Oils for Chocolate Application
  3. Ong Kuan Shiong  (co-supervision) - Identification and characterisation of antimicrobial producing bacteria isolated from tropical peat swamp forest soil
  4. Cheong Siew Loon (co-supervision) - Endophytic biocontrol agents from non-native host plants for the control of Ganoderma in oil palm

Honours Students (Completed)

  1. Gabrial Ong Ching Shien (co-supervision)
  2. Mah Wee Li (main supervision)

Academic/Corporate Community Engagements

International Presentations

  • 2017, Choo, KB, Lee, SM, Lee, WL, and Cheow, YL Palladium complex of racemic bidentate pyridine N-Heterocyclic Carbene (NHC): Antimicrobial and cell cytotoxicity studies18th Asian Edition Tetrahedron Symposium, Melbourne Australia.
  • 2017, Choo, KB, Lee, SM, Lee, WL, and Cheow, YL Optical resolution, antimicrobial and cell cytotoxicity studies of racemic palladium pyridine N-Heterocyclic carbene (NHC) complexes. 6th Asian Conference on Coordination Chemistry, Melbourne Australia.
  • 2011, Yuen Lin Cheow, Sumod A. Pullarkat, Yongxin Li, Pak-Hing Leung, Asymmetric hydroarsination reactions toward synthesis of alcohol functionalised C-chiral As-P ligands promoted by chiral cycometallated complexes. 241st ACS National Meeting and Exposition (United States of America)
  • 2010, Yuen Lin Cheow, Shuli Chen, Sumod A. Pullarkat, Yongxin Li and Pak-Hing Leung. Insertions of alkynylarsines into the Pd-C bond of cycolpalladated complexes. 6th Asian-European Symposium on Metal Mediated Efficient Reactions. (Singapore)