Kirti Shukla



PhD (University of Heidelberg, Germany)
Telephone: +603 5514 6000
Ext: 59621 (DID: 5519 9621)
Room number: 4-8-35

Cancer Biology, Molecular Biology, Signalling Pathways, Genome Analysis, RNA biology.

  1. Study of PIK3CA mutation hotspots in breast cancer patients with APOBEC3B deletion polymorphism
  2. Role of miRNAs in regulation of NF-κB signaling and cell cycle progression pathways in an infectious disease model
  3. Effect of miRNAs expression on regulation of tumour cell survival in response to oxidative stress

Yehoshua Enuka Morris E. Feldman Animesh Chowdhury Swati Srivastava Moshit Lindzen Aldema Sas-Chen Renaud Massart David Cheishvili Matthew J. Suderman Yoav Zaltsman Chiara A. Mazza Kirti Shukla Cindy KörnerNoa Furth Mattia Lauriola Moshe Oren Stefan Wiemann Moshe Szyf Yosef Yarden. Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone. Nucleic Acids Research, 2017 Sep 28.

Shukla K, Sharma AK, Ward A, Will R, Hielscher T, Balwierz A, et al. MicroRNA-30c-2-3p negatively regulates NF-kappaB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. Molecular oncology. 2015 Feb 10. PubMed PMID: 25732226. 

Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O, et al. MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. The Journal of pathology. 2014 Apr 21. PubMed PMID: 24752803. 

Ben-Chetrit N, Chetrit D, Russell R, Korner C, Mancini M, Abdul-Hai A, Shukla K, et al. Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. Science signaling. 2015 Jan 20;8(360):ra7. PubMed PMID: 25605973. 

Kostler WJ, Zeisel A, Korner C, Tsai JM, Jacob-Hirsch J, Ben-Chetrit N, Sharma, K*, et al. Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration. PloS one. 2013;8(12):e80566. PubMed PMID: 24324612. Pubmed Central PMCID: 3855657.

Srivastava S, Sharma, K*, Kumar N, Roy P. Bradykinin regulates osteoblast differentiation by Akt/ERK/NFkappaB signalling axis. Journal of cellular physiology. 2014 May 13. PubMed PMID: 24825463. 

Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Sharma, K*, et al. Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment. Nature communications. 2014;5:5073. PubMed PMID: 25278152. Pubmed Central PMCID: 4205848. 

Aleksandra Balwierz, Alexander Bott, Christian Breunig, Nese Erdem, Chiara Giacomelli, Cindy Körner, Omar Salem, Kirti Shukla, Stefan Wiemann. microRNAs – kleine Moleküle ganz groß. Biologie in unserer Zeit, (2014); Doi:10.1002/biuz.201410543 

*Maiden name

Masters student (Present)

  • Kavitha Ganesan Nathan (Co-supervision)

PhD students (Present)

  • Nur Zawanah binti Zabidi (Co-supervision)
  • Md Moinul Hoque (Co-supervision)
  • Rasaq Olajide Akinsola (Co-supervision)

Third Year Project students (Present)

  • Abyramy Srikanth
  • Nazifa Tabassum
  • Cancer Research Malaysia - Scientist
  • German Breast Group, Germany - Translational Scientist
  • Toxicology and Applied Pharmacology - Reviewer
  • YOUNG SCIENTISTS NETWORK- Academy of Sciences Malaysia (YSN-ASM) - Science Communicator

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