Lee Wai Leng



PhD (Academia Sinica and National Chung Hsing University, Taiwan)
Telephone: (+603) 5514 6000,
Ext: 46098 (DID: 5514 6098)
Room number: 4-8-37 (Building 4, Level 8, No. 37)

Ethnobotany, Cancer Cell Biology, Proteomics

  • Discovery of novel targetable pathways in cancer treatments - Several novel signaling pathways in breast cancer were discovered in my previous study. Among the components involved in these pathways, exosome is an extremely intriguing target in cancer treatment. Currently, one of the research projects in my laboratory aims to investigate the links between oncogenic mutation and exosome-mediated carcinogenesis. 
  • Development of novel treatment options involve phytochemicals to provide breakthrough in treating life-threatening cancer diseases - Concerns about drug resistance and side effects of currently used therapeutic agents have raised interest in phytochemicals derived from dietary foods and traditional medicines which allow safe and continuing ingestion. Therefore my research also aims to discover the therapeutic use of local medicinal plant-derived phytochemicals in cancer treatment.

Peng Nian Yew, Wai-Leng Lee, Yau Yan Lim. 2017. Antioxidant and intracellular ROS scavenging activities of three porcupine bezoars from Hystrix brachyuran. Pharmacognosy Research. DOI: 10.4103/pr.pr_145_16

Loh Teng-Hern Tan, Kok-Gan Chan, Priyia Pusparajah, Wai-Leng Lee, Lay-Hong Chuah, Tahir Mehmood Khan, Learn-Han Lee, and Bey-Hing Goh. 2017. Targeting membrane lipid a potential cancer cure?. Frontiers in Pharmacology. 8: Article 12.

Kuang-Ming Shang, Tzu-Hsuan Su, Wai-Leng Lee, Wen-Wei Hsiao, Ching-Yi Chiou, Bing-Ying Ho, Sheng-Yang Wang, Lie-Fen Shyur. 2017. Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47d breast cancer. Phytomedicine. 24: 39-48.

Hui-Mei Lee, Vyomesh Patel, Lie-Fen Shyur, Wai-Leng Lee. 2016. Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Phytomedicine. 23: 1535-44.

Kyoko Nakagawa-Goto, Jo-Yu Chen, Yu-Ting Cheng, Wai-Leng Lee, Munehisa Takeya, Yohei Saito, Kuo-Hsiung Lee, Lie-Fen Shyur. 2016. Novel sesquiterpene lactone analogues as potent anti-breast cancer agents. Molecular Oncology. 10: 921-37.

Wai-Leng Lee, Jing-Ying Huang and Lie-Fen Shyur. (2013). Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxidative Medicine and Cellular Longevity. Special Issue: Nucleic Acid Oxidation in Human Health and Disease. Vol 2013: 925804. DOI: 10.1155/2013/925804.

Lie-Fen Shyur, Wai-Leng Lee, Jeng-Yuan Shiau, Laiqiang Ying, Jacquelyn Gervay-Hague. (2013). Optical imaging of molecular targets of phytoagent deoxyelephantopin against mammary adenocarcinoma cell activities. FASEB Journal. 27: 663.1. 

Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation. Free Radical Biology & Medicine 2012 52: 1423-1436. Wai-Leng Lee and Lie-Fen Shyur.

Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of Proteome Research 2010 9: 237-253. Wai-Leng Lee, Tuan-Nan Wen, Jeng-Yuan Shiau and Lie-Fen Shyur.

Book Chapter

Peng-Nian Yew, Kan-Fu Oh, Wai-Leng Lee. 2016. Pro-oxidative phytoagents iInduce autophagy in tumors: Villain or benefactor in cancer treatment? In Autophagy: Cancer, other Pathologies, Inflammation, Immunity, Infection and Aging (Vol. 8). M.A. Hayat (ed.) Elsevier. pp 307 –23.

Peng-Nian Yew, Kan-Fu Oh and Wai-Leng Lee. (2015) Pro-oxidative phytoagents induce autophagy in tumors: Villain or benefactor in cancer treatment? AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, M. A. Hayat (Editor), Elsevier. (Book chapter in revision) 

Wai-Leng Lee, Jeng-Yuan Shiau and Lie-Fen Shyur (2012) Taxol, camptothecin and beyond for cancer therapy. pp 133-178. In: Lie-Fen Shyur (ed.) Advances in Botanical Research (Vol. 62): Recent Trends in Medicinal Plants Research. Elsevier.

Chun-Hung Lin, Wai-Leng Lee and Lie-Fen Shyur (2011) An overview of the current development of phytoremedies for breast cancer. pp 47-67. In: William Cho (ed.) Materia Medica for Various Cancers: Evidence-Based Anticancer Complementary and Alternative Medicine 2. Springer Science+Business Media B.V.

PhD Students (Present)

  1. Eng Shu Kee
  2. Khoo Xin Hui
  3. Lai Kah Man

Masters Student (Present)

  1. Eunice Yap Xin Le

Honours Students (Present)

  1. Mohamed Nor Azizi
  2. Chew Kah Yan

Honours Students (Completed)

  1. Lee Hui Mei
  2. Shih Chih Tao
  3. Clairissa Joan Ping Ping Lee
  4. Nurul Syuhada Zulhaimi
  5. Ilma Ruzni Imtiaz


Lie-Fen Shyur, Jia-Hua Feng, Wai-Leng Lee, Jo-Yu Chen, Yu-Ting Cheng, Jing-Ying Huang, Kuo-Hsiung Lee, Kyoko Nakagawa Goto. “NOVEL SESQUITERPENE DERIVATIVES AND THEIR USE IN INFLAMMATION AND CANCER TREATMENT” Attorney Docket No. 10011-044PCT, pending.