Sunil K. Lal
Professor of Microbiology
PhD in Microbial Genetics (Georgia Tech. USA)
Telephone: (+603) 5514 6000,
Room number: 4-8-16 (Building 4, Level 8, No. 16)
- Area of Expertise
- Research Interest
- Selected Journal Papers
- Books and Book Chapters
- Postgraduate Research Supervision
Translational outcomes on emerging viral diseases using Systems Virology approaches to new anti-viral targets, drug repositioning and disease biomarker discovery. High throughput screenings using CRISPR-Cas and viral minigenome simulation assays. Virus-host relationships and host innate immune responses. Viral receptor discovery.
- Systems biology based transcriptome/interactome models identifying new anti-viral targets, drug repositioning and disease biomarker discovery for viral diseases.
- Molecular approaches to modulating innate immune response to reduce viral disease severity and pathogenesis.
- High throughput screening using newly developed CRISPR-Cas and viral minigenome simulation screens.
Selected Journal Papers
A. Sharma, S. K. Lal. 2016. Zika Virus: Transmission dynamics and modes of detection. Frontiers in Microbiology doi: 10.3389/fmicb.2017.00110
J. Batra, S. Tripathi. ... S. Sambhara, S. K. Lal. 2016. Human heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Scientific Reports (Nature Publishing Group) 6:19063. doi: 10.1038/srep19063
A. K. Mayank, S. Sharma, H. Nailwal, S. K. Lal. 2015. Nucleoprotein of Influenza A virus negatively regulates anti-apoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication. Cell Death & Disease (Nature Publishing Group) 6:e2018. doi: 10.1038/cddis.2015.360.
H. Nailwal, S. Sharma, A. K. Mayank, S. K. Lal. 2015. The Nucleoprotein of Influenza A virus induces p53 signaling and apoptosis via attenuation of host Ubiquitin ligase RNF43. Cell Death & Disease (Nature Publishing Group) 6:e1768. doi: 10.1038/cddis.2015.131.
S. Tripathi, W. Cao, K. Sharma, J.R. Patel, P. Ranjan, .... S. Sambhara, S. K. Lal. 2013. Influenza A virus Nucleoprotein induces cell death in human lung epithelial cells by targeting Clusterin. Cell Death & Disease (Nature Publishing Group) 4: e562; doi:10.1038 / cddis.2013.89
P. Gaur, P. Ranjan, S. Sharma, …. S. Sambhara, S. K. Lal. 2012. Influenza A virus Neuraminidase protein enhances cell survival through interaction with CEACAM6. J. Biol. Chem. 287:15109-15117.
S. Karjee, A. Minhas, V. Sood, S. S. Ponia, A. C. Banerjea, V. T. K. Chow, S. K. Mukherjee, S. K. Lal. 2010. The 7a accessory protein of SARS-CoV acts as a RNA silencing suppressor. J. Virol. 84:10395-10401.
H-L. J. Oh, S. Akerstrom, S. Shen, S. Bereczky, H. Karlberg, J. Klingström, S. K. Lal, A. Mirazimi, Y-J Tan. 2010. An antibody against a novel and conserved epitope in the 1 HA1 subunit neutralizes numerous H5N1 influenza viruses. J. Virol. 84: 8275-8286.
M. Surjit, S. K. Lal. 2007. Glycogen synthase kinase phosphorylates and regulates the stability of p27kip1 protein. Cell Cycle 6:580-588.
M. Surjit, S. Jameel, S. K. Lal. 2007. Cytoplasmic localization of the ORF2 protein of Hepatitis E virus is dependent on its ability to undergo retro-translocation from the endoplasmic reticulum. J. Virol. 81: 3339-3345.
M. Surjit, B. Liu, V. T. K. Chow, S. K. Lal. 2006. The Nucleocapsid protein of SARS-coronavirus inhibits the activity of cyclin-CDK complex and blocks S phase progression in mammalian cells. J. Biol. Chem. 281:10669-10681.
M. Surjit, R. Oberoi, R. Kumar, S. K. Lal. 2006. Enhanced a1 microglobulin secretion from Hepatitis E virus ORF3 expressing human hepatoma cells is mediated by the tumor susceptibility gene 101. J. Biol. Chem. 281:8135-8142.
S. Tyagi, M. Surjit, S. K. Lal. 2005. The 41-amino acid C-terminal region of the Hepatitis E virus ORF3 protein interacts with Bikunin, a Kunitz-type serine protease inhibitor. J. Virol. 79:12081-12087.
M. Surjit, S. Jameel, S. K. Lal. 2004. The ORF2 protein of Hepatitis E virus binds the 5’ region of viral RNA. J. Virol. 78:320-328.
S. Tyagi, H. Korkaya, M. Zafrullah, S. Jameel, S. K. Lal. 2002. The phosphorylated form of ORF3 protein of Hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2. J. Biol. Chem. 277:22759-22767.
S. Tyagi, S. Jameel, S. K. Lal. 2001. Self-association and mapping of the interaction domain of the Hepatitis E Virus ORF3 protein. J. Virol.75:2493-2498.
N. Shanker, S. K. Lal. 2011. SAARC nations and the risk of Influenza (ed. S. Soz, R. N. Srivastava & S. Gupta) SAARC Building Bridges in the South Asian Region. New Delhi. p331-344.
M. Surjit, S. K. Lal. 2010. ORF3 protein of Hepatitis E virus: possible structural and regulatory functions during viral pathogenesis. (eds. D. Raghunath & V. Nagaraja) Mechanisms of microbial pathogenesis. Macmillan, Bangalore. p168-182.
M. Surjit, S. K. Lal. 2010. The nucleocapsid protein of the SARS Coronavirus: structure, function and therapeutic potential. (ed. S. K. Lal) Molecular Biology of the SARS-Coronavirus. Springer. Germany. p129-151.
J. Pramod, S. Sharma, S. Goyal, K. Soni, M. Chaudhery, S.K. Lal. 2010. Prevalent, Sustained and Emerging Bacterial & Viral Infections: a growing challenge for SAARC nations. (ed. S. Soz & R. N. Srivastava) SAARC Emerging challenges. New Delhi. p227-242.
K. Sharma, S. K. Lal. 2009. Potential Disasters – infectious viral diseases. (ed. K. K. Singh) Disaster Management. Section 6, Chapter 25. Ashish Publishing House Corporation, New Delhi.
N. Shanker, S. K. Lal. 2009. The molecular biology of emerging viral diseases. (ed. A. K. Chauhan & A. Varma) A Textbook of Molecular Biotechnology. IK International Publishing House Pvt. Ltd., New Delhi. (ISBN 978-93-80026-37-4), p879-904.
S. K. Lal. 2008. The threat of emerging viral diseases in SAARC nations. (ed. I. A. Saradgi, S. K. Sahni & R. N. Srivastava) SAARC Socio-Economic Transformation. Foundation for Peace & Sustainable Development, New Delhi. (ISBN 81-903823-1-4), p255-262.
Sunil K. Lal (2006) Emerging Viral Diseases of South-East Asia. Karger. ISBN-10: 3-8055-8175-0
Sunil K. Lal (2007) The Biology of Emerging Viruses. ISBN-978157331-690-3; Pages: 250
Hemant J. Purohit, Jitender P. Khurana, Rakesh Sharma, Sunil K. Lal & Vipin C. Kalia (2008) Indian Journal of Microbiology. Special Issue on Bacterial Diversity, Genomics & Metagenomics. Springer. ISSN-0046-8991
Sunil K. Lal (2010) Molecular Biology of the SARS-Coronavirus. Springer. ISBN 3642036821, 9783642036828
Sunil K. Lal (2009) Indian Journal of Microbiology. Special Issue on Swine Flu Pandemic. Springer. ISBN 3642036821
PhD students (Present)
1. Chai Jing Yun
2. Anshika Sharma
3. Ramandeep Kaur
4. Irene Lau
5. Kaviyha Ganeshan
PhD students (completed)
1. Dr. Asad Ullah Khan
2. Dr. Shweta Tyagi
3. Dr. Milan Surjit
4. Dr. Ruchi Oberoi Ratra
5. Dr. Kulbhushan Sharma
6. Dr. Namita Satija
7. Dr. Bhavna Varshney
8. Dr. Vahid Baniasadi
9. Dr. Pratibha Gaur
10. Dr. Neha Shanker
11. Dr. Shashank Tripathi
12. Dr. Shipra Sharma
13. Dr. Jyoti Batra
14. Dr. Himani Nailwal
15. Dr. Adarsh Mayank
16. Dr. Rashmi Sharma
17. Dr. Vandana Thukral
Honours students (Current)
1. Isra Ahmad
2. Zhi Ying Kho
- Elected Fellow of the Indian Academy of Sciences (FNASc), Allahabad, India (2009)
- Options for the Control of Influenza, Hong Kong (2010) – Recipient of Scholarship Award
- Young Investigators Award 2002 from the Asia-Pacific Association for the Study of Liver (APASL). Awarded at Taipei, Taiwan September 26, 2002.
- 50th Anneversary Travel Award: American Association for the Study of Liver Disease (AASLD): Awarded at Boston, Oct. 25, 2003.
- International Society for Infectious Diseases (ISID): 11th ICID New Investigator award. Awarded at Cancun, Mexico March 4, 2004.
- International Ambassador of the year 2006 Award. From the American Society for Microbiology, Washington DC. Awarded at the 106th General meeting, Orlando, FL, USA May 24, 2006.
- A process for producing recombinant Matrix 1 protein (M1) Capsid Like Proteins (CLPs) and their use as potential influenza vaccine candidate. Vahid Baniasadi & Sunil K. Lal. Indian Patent Application No. 91/DEL/2013; Application filed: 2013