Tan Ji Wei

Lecturer
School of Science

tan.jiwei@monash.edu
+603 5515 9723
Room 4-8-30
https://orcid.org/0000-0001-6806-0358

Dr. Tan Ji Wei completed his BSc in 2011 (Biomedical Science), MSc in 2013 (Cell Biology) and PhD (Immunopharmacology) in 2016 from Universiti Putra Malaysia. Shortly after his PhD graduation, Dr Tan was appointed to a lecturer position in the School of Science in January 2018. During his PhD study, he managed to develop a mast cell stabilizer from a synthetic compound originated from a natural plant. His current research interest is still focusing on the capabilities of natural products as an alternative treatment against various human ailments including allergic diseases, cancer, and neurodegenerative diseases. Specifically, he is exploring how a natural compound play its beneficial role within a cell by looking at the cellular and molecular signalling pathways.

Qualifications

  • Doctor of Philosophy in Immunopharmacology, Universiti Putra Malaysia, 2018
  • Master of Science in Cell Biology, Universiti Putra Malaysia, 2013
  • Bachelor of Science (Honours) in Biomedical Sciences, 2011

Expertise

  • Immunopharmacology
  • Experimental therapeutics of human diseases using phytochemical compounds
  • Cellular and molecular signaling pathways
  • Neurobiology

Research Interests

  • Discover the potential health benefits of phytochemical compounds against various human diseases including inflammation, allergy, cancer and neurotoxicity.
  • Explore a compound’s capability at the cellular and molecular level within a cell.

Teaching

PHA3800 (Fundamentals of Toxicology)

HUP3820 (Principles of Pathology 2)

Scholarly Journals

Ji Wei Tan, Chau Ling Tham Mast Cells in Allergy: The Potential Molecular Targets in the Upstream Signalling Pathways. Life sciences medicine and biomedicine. 2018, 2: 14

Ji Wei Tan, Daud Ahmad Israf, Nur Fariesha Md Hashim, Yoke Kqueen Cheah, Hanis Hazeera Harith, Khozirah Shaari, Chau Ling Tham. 2017. LAT is Essential for the Mast Cell Stabilising Effect of tHGA in IgE-Mediated Mast Cell Activation. Biochem. Pharm. 2017, 144: 132-148.

Ji Wei Tan, Daud Ahmad Israf, Hanis Hazeera Harith, Nur Fariesha Md Hashim, Chean Hui Ng, Khozirah Shaari, Chau Ling Tham. Anti-allergic Activity of 2,4,6-Trihydroxy-3-Geranylacetophenone (tHGA) via Attenuation of IgE-Mediated Mast Cell Activation and Inhibition of Passive Systemic Anaphylaxis. Toxicol. Appl. Pharmacol. 2017, 319, 47-58.

Ji Wei Tan, Min Kyu Kim. Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway. Molecules 2016, 21: pii: E548.

Ji Wei Tan, Chau Ling Tham, Daud A. Israf, Sang Hyub Lee, Min Kyu Kim. Neuroprotective Effects of Biochanin A Against Glutamate- Induced Cytotoxicity in PC12 Cells Via Apoptosis Inhibition. Neurochemical Research 2013, 38: 512-518.

Research Grants

  • Tan, J.W., Goh, J.K., Tham C.L., 2019, Solving the myth: does kelulut honey alleviate or exacerbate allergy?, Fundamental Research Grant Scheme, Ministry of Education, RM105k
  • Tan J.W., Tham, C.L., 2016, Determination of Linker for Activation of T cells (LAT) As the Molecular Target of tHGA in LAT and LAT2 Deficient RBL-2H3 Cells through the Release of Proinflammatory Mediators, IPS Research Grant, Universiti Putra Malaysia, RM20k

Honours Students (Present)

  1. Elvia Ramawy

Professional Membership/Associations

Membership in Academic Editorial Committees

  • Journal of Visualized Experiments (JoVE) (Journal Reviewer)
  • Neurotixicity Research ((Journal Reviewer)

Engagement with Premier Public Universities

  • Universiti Putra Malaysia (Research collaborator since 2017)

Member of Professional Bodies

  • Malaysian Society of Neuroscience (MSN) (Member since 2011)

Academic/Corporate Community Engagements

Local presentations

Poster

  • Ji Wei Tan, Daud Ahmad Israf Ali, Khozirah Shaari, Chau Ling Tham.  2, 4, 6-Trihydroxy-3-Geranylacetophenone (tHGA) Inhibits IgE-Mediated Degranulation by Suppressing the Production of Key Mediators in Rat Basophilic Leukemia RBL-2H3 Cells.  Faculty Excellence Month 2015, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.

International Presentations

Poster

  • Ji Wei Tan, Daud Ahmad Israf, Khozirah Shaari, Chau Ling Tham. Oral Administration of a Potential Mast Cell Stabilizer, tHGA, Prevents IgE- Mediated Anaphylaxis in Rats. Joint Congress of Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI) and Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (APAPARI) 2016. The Era of Allergy: Local and Global Insights and Intervention. 17th-20th October 2016. Shangri-La Hotel, Kuala Lumpur, Malaysia.
  • Ji Wei Tan, Daud Ahmad Israf Ali, Khozirah Shaari, Chau Ling Tham. A Phloroglucinol from Melicope ptelefolia Attenuates IgE- Mediated Mast Cell Degranulation via Calcium-Dependent Signalling Pathways. International Congress of Immunology 2016, 21st- 26th August 2016, Melbourne, Australia.
  • Ji Wei Tan, Daud Ahmad Israf Ali, Khozirah Shaari, Chau Ling Tham. 2, 4, 6-Trihydroxy-3-Geranylacetophenone (tHGA) Inhibits Newly Synthesized Mediators Release in IgE-Mediated Mast Cell Degranulation. International Anatomical and Biomedical Scientific Conference (IABS) 2015 “From Cell Towards Translational Medicine” 18th-20th August 2015, Faculty of Medicine and Health Sciences, University Putra Malaysia.
  • Ji Wei Tan, Daud Ahmad Israf Ali, Khozirah Shaari, Chau Ling Tham. In vitro Inhibitory Effects of 2, 4, 6-Trihydroxy-3-Geranylacetophenone (tHGA) on IgE-Mediated Mast Cell Degranulation. INTRACOM 2014. 30th October – 2nd November 2014. Sunway Convention Centre, Kuala Lumpur.
  • Ji Wei Tan, Min Kyu Kim. Protective effect of biochanin A on in-vitro model of Alzheimer’s disease: a possible future frontier against ageing. IAGG 2013. 23rd June – 27th June 2013. Seoul, South Korea.

Oral

  • Rohhimi Wafda, Ji Wei Tan, Daud Ahmad Israf Ali, and Chau Ling Tham. Zerumbone protects against house dust mite-induced airway epithelial barrier disruption by preserving junctional permeability and localization. International Anatomical and Biomedical Scientific Conference (IABS) 2017 “Research Advances in Health Sciences” 1st-2nd August 2017, Faculty of Medicine and Health Sciences, University Putra Malaysia.
  • Ji Wei Tan, Daud Ahmad Israf Ali, Nur Fariesha Md Hashim, Khozirah Shaari and Chau Ling Tham. Molecular Insight of A Geranyl Acetophenone in IgE-mediated Mast Cell Activation of Allergy. International Anatomical and Biomedical Scientific Conference (IABS) 2017 “Research Advances in Health Sciences” 1st-2nd August 2017, Faculty of Medicine and Health Sciences, University Putra Malaysia.

Awards

2018

  • Finalist of Doctor of Philosophy Gold Award, Regulation of IgE-mediated Mast Cell Degranulation in Allergy by Geranyl Acetophenone, Universiti Putra Malaysia

2017

  • Best Oral Presentation Award, Zerumbone protects against house dust mite-induced airway epithelial barrier disruption by preserving junctional permeability and localization, International Anatomical and Biomedical Scientific Conference (IABS)

2016

  • Patent, 2,4,6-Trihydorxy-3-Geranylacetophenone For Use As A Mast Cell Stabilizer, Universiti Putra Malaysia

2015

  • Best Poster Award, 2, 4, 6-Trihydroxy-3-Geranylacetophenone (tHGA) Inhibits IgE- Mediated Degranulation by Suppressing the Production of Key Mediators in Rat Basophilic Leukemia RBL-2H3 Cells, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia.
  • Best Poster Award, 2, 4, 6-Trihydroxy-3-Geranylacetophenone (tHGA) Inhibits Newly Synthesized Mediators Release in IgE-Mediated Mast Cell Degranulation, International Anatomical and Biomedical Scientific Conference (IABS),

2014

  • MyBrain 15 (MyPhD) study scholarship, Malaysia Ministry of Higher Education
  • Best Poster Award, In vitro Inhibitory Effects of 2, 4, 6-Trihydroxy-3- Geranylacetophenone (tHGA) on IgE-Mediated Mast Cell Degranulation, International Traditional and Complementary Medicine (INTRACOM) Conference

2011

  • Graduate Research Fellowship, Universiti Putra Malaysia
  • MyBrain 15 (MyMaster) study scholarship, Malaysia Ministry of Higher Education

2007

  • Kuok Foundation Berhad study scholarship, Kuok Foundation Berhad
  • Dean's List (6 semesters), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
  • Vice Chancellor's List (1 semester), Universiti Putra Malaysia