CMR Projects

Cardio-metabolic

Principal Researcher Co-Researchers Project Title:
Professor Dato’ Anuar Zaini Dr Badariah. Ahmad, Dr Nik Asmah Nik Hussain, Dr Quek Kia Fatt

1. Cardio-metabolic risk − Intra-abdominal Adiposity, 5A Registry

2. Switch from existing to another Insulin treatment in inadequately controlled diabetes

Dr Khalid Abdul Kadir Dr Paul Fullerton, Dr Cheryl Fullerton General practitioners implementation of normoglycaemic target (GIANT)
Dr Khalid Abdul Kadir  

1. Sitagliptin and Pioglitazine in Type 2 Diabetes

2. MK-0364 in Overweight and Obese with Type 2 diabetes

Dr Paul Ling Kah Hing Professor Dato’ Khalid Abdul Kadir

1. Clinical efficacy of a novel cholesterol agent in elevating HDL

2. Efficacy and safety of MK-0524B Combination tablet Compared to MK0524A + Simvastation Co- administration in Primary Hypercholesterolemia

Dr Paul Ling Kah Hing   Extended Release (ER) Niacin/Laropiprant in Type 2 Diabetes

Clinical trial

Principal Researcher Co-Researchers Project Title:
Dr Paul Ling Kah Hing Dr Khalid Abdul Kadir

1. A Phase 3 Randomized, Double-blind, Parallel-group, Multi-center Study of the Safety and Efficacy of Apixaban for Prophylaxis of Venus Thromboembolism in Acutely Ill Medical Subjects During and Following Hospitalization. NMRR-08-1034-2189

2. A Randomized, Double-Blind, Active-Controlled, Multicenter Study of Patients with Primary Hypercholesterolemia and High Cardiovascular Risk and not Adequately Controlled with Atorvastatin 20 mg: A Comparison of Switching to a Combination Tablet Ezetimibe/Simvastatin (10mg/40mg) versus Doubling the Baseline Dose to Atorvastatin 40 mg. NMRR-08-1355-2744

3. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Lipid -Modifying Effect and Tolerability of MK1903 in Patients with Dyslipidemia. ID: 3062

4. A 76 Week, Worldwide, Multicenter, Double-Blind, Randomized Placebo Controlled Study to Assess the Tolerability and Efficacy of MK-0859 When Added to Ongoing Therapy with A Statin in Patients with Hypercholesterolemia or Mixed Hyperlipidaemia. NMRR-08-362-1517

5. MK0736 Protocol 007 - A worldwide, multicenter, double blind, randomized, placebo controlled, dose ranging study to evaluate the efficacy, safety and tolerability of Mk-0736 when added to ongoing therapy with ACE inhibitor or ARB in patients with diabetes and hypertension. NMRR -08-1354-275

Cost effectiveness of cardiology intervention

Principal Researcher Co-Researchers Project Title:
Dr Sivalal Sadasivan Dr Christine Kennedy, Dr S. Selvamalar, Dr Amudha Kadirvelu. Cost-effectiveness of PCI (percutaneous coronary intervention) and CABG

Diabetes Complications and risk factors

Principal Researcher Co-Researchers Project Title:
Dr Amudha Kadirvelu Dr Suriati bt Hashim, Dr Rokiah Pendek, Dr Sivalal Sadasivan, Dr Shajahan Yasin, Dr Anuar Zaini Md Zain Prevalence of Diabetic complications and its risk factors
Dr Christina Gertrude Yap Dr Anuar Zaini Md Zain, Dr Iekhsan Othman Early predictors of Risk of Diabetic Nephropathy

Diabetes and obesity

Principal Researcher Co-Researchers Project Title:
Dr Anuar Zaini Md Zain Dr Khalid Abdul Kadir, Dr Nik Asmah Nik Hussain, Dr Badariah Ahmad, Dr Siti Harnida Md Isa, Dr Iekhsan Othman, Dr Quek Kia Fatt, Dr Shamsul Haque, Dr Lenore Manderson, Dr Brian Oldenburg Metabolic Response in Treatment of Diabetes with Concomitant Obesity
Dr Khalid Abdul Kadir  

1. Diabetes in Obese Patients

2. 11-b Hydroxysteroid Dehydrogenase in Diabetes & Metabolic Syndrome

Dr Paul Ling Kah Hing  

Efficacy of Lipid Lowering in Type 2 Diabetes

Dr Siti Harnida Md Isa Dr Khalid Abdul Kadir, Dr Paul Ling Kah Ling, Dr Paul Fullerton, Dr Leong Chui Chui

Metabolic Syndrome Study in Malaysia

Dr Siti Harnida Md Isa Dr Khalid Abdul Kadir Nazaimoon Wan Mohamed (IMR), Dr Anuar Zaini Md Zain, Dr Maude Phipps, Dr Badariah Ahmad and Dr Jamilah Ariffin

Diabetes and Metabolic Syndrome Study in Orang Asli – an extension of the Malaysian Metabolic Syndrome Study

Disease management

Principal Researcher Co-Researchers Project Title:
Dr Anuar Zaini Md Zain Dr Badariah Ahmad, Dr Amudha Kadirvelu., Dr Sivalal Sadasivan Effectiveness of Current Interventions for Diabetes Mellitus

Epidemiology and human genetics

Principal Researcher Co-Researchers Project Title:
Dr Maude Elvira Phipps Timothy Adrian Jinam (National Institute of Genetics, Japan), S. Saitou (National Institute of Genetics, Japan), Edison Liu(Genome Institute of Singapore), Jin Li (Fudan University, China), Mahmood Ameen (UM), Juli Edo (UM), Pan Asia SNP Consortium Mapping the genomic architecture of Asian populations as a reference point for translational medicine and disease studies.

Health education and delivery

Principal Researcher Co-Researchers Project Title:
Dr Nik Asmah Nik Hussain Dr Quek Kia Fatt, Dr Anuar Zaini, Dr Badariah Ahmad, Dr Siti Harnida, Dr Brian Oldenburg, Dr Lenore Manderson Effectiveness of Health Education on Ischemic Heart Disease (IHD) Outcomes
Dr Sivalal Sadasivan   Health Care delivery to improve outcomes for IHD

Intensive care

Principal Researcher Co-Researchers Project Title:
Dr Nor'Azim Mohd Yunos Dr Rafidah Atan Effects of intensive insulin therapy protocols on critically ill patients in intensive care

Patient participation in diabetes

Principal Researcher Co-Researchers Project Title:
Dr Badariah Ahmad Dr Siti Harnida Md Isa, Dr Shamsul Haque, Dr Nik Asmah Nik Hussain, Dr Quek Kia Fatt, Dr Anuar Zaini Md Zain, Dr Brian Oldenburg, Dr Lenore Manderson, Dr Khalid Abdul Kadir Malaysian Diabetes & Research on Lifetime Lifestyle Intervention (MY-DARLING)

Screening in diabetes

Principal Researcher Co-Researchers Project Title:
Dr Amudha Kadirvelu Dr Sivalal Sadasivan, Dr Nik Asmah Nik Hussain, Dr Khalid Abdul Kadir Micro-Albuminuria and Endothelial Dysfunction in Pre-diabetic