Ang Chee Wei

Post Doctoral Fellow
School of Science

Primary: ang.chee.wei@monash.edu
Secondary: +603 5514 6112
Room 4-8-01A

https://orcid.org/0000-0002-4512-2592

Ang Chee Wei joined Monash University Malaysia as a research fellow in August 2020. She graduated with a PhD from the Institute for Molecular Bioscience, The University of Queensland. Her PhD studies focused on development of new anti-infective agents against tuberculosis and parasitic infections. She has more than five years of experience as a research officer at the Institute for Research in Molecular Medicine, University Sains Malaysia, working on drug modification, bioconjugation, and development of immunoassays. Chee Wei has a strong interest in finding new therapeutics to address the unmet medical needs in infectious diseases. She is currently focusing on small molecule synthesis but is also venturing into natural products and metal-based bioactive compounds.

Qualifications

  • Doctor of Philosophy, The University of Queensland, 2020
  • Master of Science, Universiti Sains Malaysia (USM), 2016
  • Bachelor of Science, Universiti Sains Malaysia (USM), 2008

Expertise

Medicinal chemistry, drug discovery, organic synthesis, analytical chemistry

Research Interests

Medicinal chemistry, drug discovery, organic synthesis, infectious diseases, natural products

Scholarly Journals

Chee Wei Ang, Lendl Tan, Melissa L Sykes, Neda AbuGharbiyeh, Anjan Debnath, Janet C Reid, Nicholas P West, Vicky M Avery, Matthew A Cooper, Mark AT Blaskovich. Antitubercular and antiparasitic 2-nitroimidazopyrazinones with improved potency and solubility. Journal of Medicinal Chemistry (2020) accepted.

Asma Ulhusna Shaimi, Wan Raihana Wan Aasim, Hasmah Abdullah, Tan Soo Choon, Ang Chee Wei, Zalina Ismail. Novel approaches for detection fluorescent-labeled by Cellvizio Lab system on hippocampal CA1 region. Biology, Medicine, & Natural Product Chemistry (2019) 8, 1-6.

Angie M Jarrad, Chee Wei Ang*, Anjan Debnath, Hye Jee Hahn, Kyra Woods, Lendl Tan, Melissa L Sykes, Amy J Jones, Ruby Pelingon, Mark S Butler, Vicky M Avery, Nicholas P West, Tomislav Karoli, Mark AT Blaskovich, Matthew A Cooper. Design, synthesis, and biological evaluation of 2-nitroimidazopyrazin- one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry (2018) 61, 11349-11371. (Selected as cover article) *co-first author

Chee Wei Ang, Angie M Jarrad, Matthew A Cooper, and Mark AT Blaskovich. Nitroimidazoles – molecular fireworks that combat a broad spectrum of infectious diseases. Journal of Medicinal Chemistry (2017) 60, 7636-7657.

Keng Yoon Yeong, Chee Wei Ang, Mohamed Ashraf Ali, Hasnah Osman, Soo Choon Tan. Antituberculosis agents bearing the 1, 2-disubstituted benzimidazole scaffold. Medicinal Chemistry Research (2017) 26, 770-778.

Keng Yoon Yeong, Wai-Lam Liew, Vikneswaran Murugaiyah, Chee Wei Ang, Hasnah Osman, Soo Choon Tan. Ethyl nitrobenzoate: A novel scaffold for cholinesterase inhibition. Bioorganic Chemistry (2017) 70, 27-33.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Sy Bing Choi, Hasnah Osman, Vijay H Masand, Tan Soo Choon. Antimycobacterial activity and in silico study of highly functionalised dispiropyrrolidines. Medicinal Chemistry Research (2015) 24, 818-828.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Chern Ein Oon, Amir Nasrolahi Shirazi, Keykavous Parang. Discovery of a potent and highly fluorescent sirtuin inhibitor. MedChemComm (2015) 6, 2235-2235.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Rusli Ismail. Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters. European Journal of Medicinal Chemistry (2015) 93, 614-624.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Hasnah Osman, Keykavous Parang, Amir Nasrolahi Shirazi. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities. Bioorganic & Medicinal Chemistry (2014) 22, 703-710.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Venu Sanjeevi Lakshmipathi. Synthesis of highly functionalised dispiropyrrolidine derivatives as novel acetylcholinesterase inhibitors. Letters in Drug Design & Discovery (2014) 11, 156-161.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Hasnah Osman. A one-pot tandem synthesis of various 1,2-disubstituted benzimidazoles. Tetrahedron Letters (2014) 55, 4697-4700.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Raju Suresh Kumar. A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as
antimycobacterial agents. Bioorganic & Medicinal Chemistry Letters (2013) 23, 1383-1386.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Kooi-Yeong Khaw, Vikneswaran Murugaiyah, Hasnah Osman, Vijay H Masand. Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors. Bioorganic chemistry (2013) 49, 33-39.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Raju Suresh Kumar, Natarajan Arumugam, Abdulrahman I. Almansour, Hasnah Osman. Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines. Bioorganic & Medicinal Chemistry Letters (2012) 22, 4930-4933.

Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran. Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase, Bioorganic and Medicinal Chemistry Letters (2011) 21, 3997-4000.

Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Raju Suresh Kumar, Hasnah Osman, Elumalai Manogaran.Substituted spiro [2.3′] oxindolespiro [3.2 ″]-5, 6-dimethoxy-indane-1 ″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters (2010) 20, 7064-7066.

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Professional Association

Member of Professional Bodies

  • Royal Australian Chemical Institute - Member (MRACI), 2016-2020

Reviewer

  • Medicinal Chemistry Research (Springer)
  • Chemistry & Biodiversity (Wiley)
  • Chemical Biology & Drug Design (Wiley)
  • Medicinal Chemistry (Bentham Science)
  • Letters in Drug Design & Discovery (Bentham Science)

Academic / Corporate Community Engagements

  • EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19), Athens, Greece, 2019 (poster presentation)
  • 8th World Conference on Physico Chemical Methods in Drug Discovery and Development (IAPC-8), Split, Croatia, 2019 (poster presentation)
  • EUROPIN Summer School on Drug Design, Vienna, Austria, 2019 (poster presentation)
  • CRS Australian Chapter/Drug Delivery Australia 2019 Conference, Brisbane, Australia 2019 (poster presentation and flash talk)
  • IMB Chemistry and Structural Biology Division Symposium, Brisbane, Australia, 2019 (poster presentation)
  • The RACI Medicinal Chemistry and Chemical Biology Conference, Brisbane, Australia, 2018 (oral presentation)
  • 2nd Queensland Annual Chemistry Symposium, Brisbane, Australia, 2017 (oral presentation)
  • IMB HDR Student Symposium, UQ, Brisbane, Australia, 2017 (poster presentation)
  • SBMS - 8th International Postgraduate Symposium, UQ, Brisbane, Australia, 2017 (poster presentation)
  • 1st Queensland Annual Chemistry Symposium, Brisbane, Australia, 2016 (poster presentation)
  • Workshop on Lateral Flow Assay Technology, Universiti Sains Malaysia, 2015 (invited speaker)
  • 4th Regional Conference on Molecular Medicine, Penang, Malaysia, 2011 (poster presentation)

Awards

  • Candidate Development Award (CDA), The University of Queensland, 2019
  • Best poster prize at CRS Australian Chapter/Drug Delivery Australia Conference, 2019
  • Oral talk prize at The RACI Medicinal Chemistry and Chemical Biology Conference, 2018
  • Research Training Program Scholarship (formerly known as IPRS), The University of Queensland, 2016-2019
  • Dean’s List, School of Chemical Sciences, Universiti Sains Malaysia, 2005-2008